The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Structure and mechanism of the RNA polymerase II transcription machinery
Open accessAbstract
RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences. To execute these essential functions, an array of proteins and protein complexes interact with Pol II to regulate its activity. In this review, we detail the structure and mechanism of over a dozen factors that govern Pol II initiation (e.g., TFIID, TFIIH, and Mediator), pausing, and elongation (e.g., DSIF, NELF, PAF, and P-TEFb). The structural basis for Pol II transcription regulation has advanced rapidly in the past decade, largely due to technological innovations in cryoelectron microscopy. Here, we summarize a wealth of structural and functional data that have enabled a deeper understanding of Pol II transcription mechanisms; we also highlight mechanistic questions that remain unanswered or controversial.
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Cites
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Cited by
El Khattabi, L., Zhao, H., Kalchschmidt, J., Young, N., Jung, S., Van Blerkom, P., Kieffer-Kwon, P., Kieffer-Kwon, K.-R., Park, S., Wang, X., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.011 · Cited by 244
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
Muniz, L., Nicolas, E., & Trouche, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020105740 · Cited by 198
“P-TEFb is recruited to promoters through interactions with transcription factors, Mediator, and coactivators (Li et al , 2018).”
InfluentialThe NuRD complex in neurodevelopment and disease: a case of sliding doors
Boulasiki, P., Tan, X. W., Spinelli, M., & Riccio, A. (2023) · Cells · doi:10.3390/cells12081179 · Cited by 22
Structural properties of the HNF-1A transactivation domain
Kind, L., Driver, M., Raasakka, A., Onck, P. R., Njølstad, P. R., Arnesen, T., & Kursula, P. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1249939 · Cited by 10
Metadata
- Authors
- Schier, A. C., & Taatjes, D. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2020-04-01
- Volume
- 34
- Issue
- 7-8
- Pages
- 465-488
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W3014900738
- Cited by
- 294
- References
- 235
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Schier, A. C., & Taatjes, D. J. (2020). Structure and mechanism of the RNA polymerase II transcription machinery. Genes & Development. https://doi.org/10.1101/gad.335679.119
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