The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clonal and systemic analysis of long-term hematopoiesis in the mouse.
Open accessAbstract
We have analyzed the temporal in vivo fate of 142 individual stem cell clones in 63 reconstituted mice. Long-term sequential analyses of the four major peripheral blood lineages, obtained from animals engrafted with genetically marked stem cells, indicate that developmental behavior is primarily a function of time. As such, the first 4-6 months post-engraftment is characterized by frequent fluctuations in stem cell proliferation and differentiation behavior. Gradually, a stable hematopoietic system emerges, dominated by a small number of totipotent clones. We demonstrate that single stem cell clones are sufficient to maintain hematopoiesis over the lifetime of an animal and suggest that mono- or oligoclonality may be a hallmark of long-term reconstituted systems. A model is proposed, wherein lineage-restricted differentiation and dramatic clonal flux are consequences of mechanisms acting on an expanding pool of totipotent cells and are not indicative of intrinsically distinct stem cell classes.
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Cites
Growth and Differentiation in the Hemopoietic System
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Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny
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Yu, K.-R., Espinoza, D. A., Wu, C., Truitt, L., Shin, T.-H., Chen, S., Fan, X., Yabe, I. M., Panch, S., Hong, S. G., et al. (2018) · Blood · doi:10.1182/blood-2017-08-802033 · Cited by 47
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Metadata
- Authors
- Jordan, C. T., & Lemischka, I. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-02
- Volume
- 4
- Issue
- 2
- Pages
- 220-232
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2158800860
- Cited by
- 547
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
