The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio +4 more·2007·Genes & Development
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- CDKN2A Determines Mesothelioma Cell Fate to EZH2 InhibitionGiulia Pinton, Zejing Wang, Cecilia Balzano, Sara Missaglia, Daniela Tavian, Renzo Luciano Boldorini, Dean Anthony Fennell, Martin Griffin, Laura Moro · 2021 · Frontiers in Oncology
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- Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescenceMariangela Succoio, Marika Comegna, Chiara DˈAmbrosio, Andrea Scaloni, Filiberto Cimino, Raffaella Faraonio · 2015 · Journal of Proteomics
- Molecular mechanisms of cellular senescence and immortalization of human cellsTohru Kiyono · 2007 · Expert Opinion on Therapeutic Targets
- Reduced Geminin levels promote cellular senescenceMaria S. Iliou, Panoraia Kotantaki, Dimitris Karamitros, Μάγδα Σπέλλα, Stavros L. Taraviras, Zoi Lygerou · 2012 · Mechanisms of Ageing and Development
- Epigenetic Regulation in Cell Reprogramming Revealed by Genome-Wide AnalysisChang Pyo Hong, Jihwan Park, Tae‐Young Roh · 2011 · Epigenomics
- Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic FibroblastYoyo Chih-Yun Yu, Tony Hui, Tzu-Hao Kao, Hung‐Fu Liao, Chih-Yi Yang, Chia‐Chun Hou, Hsin-Ting Hsieh, Jen‐Yun Chang, Yi‐Tzang Tsai, Marina Pinskaya et al. · 2020 · Frontiers in Cell and Developmental Biology
- Cellular Senescence: Many Roads, One Final DestinationRaya Hamad Saab · 2010 · The Scientific World JOURNAL
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- A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cellsRachel McCole, James Nolan, David M Reck, Craig Monger, Samantha Rustichelli, Eric Conway, Gerard L. Brien, Cheng Wang, Orla Deevy, Hannah K. Neikes et al. · 2025 · Cell Reports
- Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing SenescenceAnthony J. Bainor, Fang‐Ming Deng, Yu Wang, Peng Lee, David John Cantor, Susan K. Logan, Gregory David · 2017 · Cancer Research
- Chromatin: the old and young of itFelicity J. Emerson, Siu Sylvia Lee · 2023 · Frontiers in Molecular Biosciences
- Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexesNadine Martin, Selina Raguz, Gopuraja Dharmalingam, Jesús Gil · 2013 · Cell Cycle
- Investigation of the relationship between chromobox homolog 8 and nucleus pulposus cells degeneration in rat intervertebral discXu Zhou, Hailong Zhang, Guangfei Gu, Yue Ding, Jian-Bo Jia, Qingsong Fu, Shisheng He · 2013 · In Vitro Cellular & Developmental Biology - Animal
- Chromatin changes trigger laminin genes dysregulation in aging kidneysOleg N. Denisenko, Daniel Mar, Matthew Trawczynski, Karol Bomsztyk · 2018 · Aging
- Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult HematopoiesisCarmela Calés, Leticia Pavón, Katarzyna Starowicz, Claudia Pérez‐Martínez, Mónica Bravo, Tomokatsu Ikawa, Haruhiko Koseki, Miguel Vidal · 2015 · Molecular and Cellular Biology
- Epigenetic Signatures and Plasticity of Intestinal and Other Stem CellsMadhurima Saxena, Ramesh A. Shivdasani · 2020 · Annual Review of Physiology
- A methylation-phosphorylation switch controls EZH2 stability and hematopoiesisPengfei Guo, Rebecca C. Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang · 2024 · eLife
- Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virusCollin M. Bantle, C. Tenley French, Jason E. Cummings, Shankar Sadasivan, Kevin Tran, Richard A. Slayden, Richard Jay Smeyne, Ronald B. Tjalkens · 2021 · PLoS ONE
- Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemiaEmmanuel J. Volanakis, Mark Robin Boothby, Charles J. Sherr · 2012 · Experimental Hematology
- Novel Aspects in Acute Lymphoblastic LeukemiaStefan H Faderl · 2011 · InTech eBooks
- BMI1 Roles in Cancer Stem Cells and Its Association with MicroRNAs Dysregulation in Cancer: Emphasis on Colorectal CancerMohammad Hasan Soheilifar, Abdolvahab Moshtaghian, Hamid Maadi, Fereshteh Izadi, Massoud Saidijam · 2018 · International Journal of Cancer Management
- Cancers and the concept of cell senescenceA. Macieira‐Coelho · 2009 · Biogerontology
- Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani populationSyed Kashif Nawaz, Aasma Noreen, Asima Rani, Memoona Yousaf, Muhammad Arshad · 2015 · The Anatolian Journal of Cardiology
- Systemic epigenetic dysregulation as a driver of ageing and a therapeutic targetAli Doğa Yücel, Vadim N. Gladyshev · 2026 · Nature Reviews Molecular Cell Biology
- EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cellsAmador Gallardo, Lourdes López-Onieva, Efres Belmonte‐Reche, Iván Fernández-Rengel, Andrea Serrano-Prados, Aldara Molina, Antonio Sánchez–Pozo, David Landeira · 2024 · Cell Death and Disease
- Increased chromatin accessibility underpins senescenceStéphane Lopes‐Paciencia, Gerardo Ferbeyre · 2025 · FEBS Journal
- A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline gliomaEimear Lagan, Dáire Gannon, Ademar Jesus Silva, Peter Bibawi, Anthony M. Doherty, Darragh Nimmo, Rachel McCole, Craig Monger, Giovani Luiz Genesi, Aurelie Vanderlinden et al. · 2025 · Molecular Cell
- At the Crossroads of Life and Death: The Proteins That Influence Cell Fate DecisionsVinesh Dhokia, John A. Y. Moss, Salvador Macip, Joanna L. Fox · 2022 · Cancers
- Validation of signalling pathways: Case study of the p16-mediated pathwayNimet İlke Akçay, Rza Bashirov, Şükrü Tüzmen · 2014 · Journal of Bioinformatics and Computational Biology
- Alternative Chemotherapeutic Agents for the Treatment of Retinoblastoma Using the Intra-Arterial and Intravitreal Routes: A Path Forward Toward Drug DiscoveryShuai Yuan, Debra L. Friedman, Anthony B. Daniels · 2016 · International Ophthalmology Clinics
- Chromatin Bottlenecks in CancerJay F. Sarthy, Steven Henikoff, Kami Ahmad · 2019 · Trends in cancer
- Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblastsNarisu Narisu, Rebecca Rothwell, Peter Vrtačnik, Sofía Rodríguez, John P. Didion, Sebastian K. Zöllner, Michael R. Erdos, Francis S. Collins, Maria Eriksson · 2019 · Aging Cell
- Targeting the EZH2-PPAR Axis Is a Potential Therapeutic Pathway for Pancreatic CancerJi-Long Hu, Zhinan Zheng, Jia Lei, Yuxin Cao, Qiyun Li, Zhi Gang Zheng, Chuanjun Chen · 2021 · PPAR Research
- Histone méthyltransférasesHassiba Chaib, Thomas Prébet, Norbert Vey, Yves Collette · 2011 · médecine/sciences
- Near‐to‐perfect homeostasis: Examples of universal aging rule which germline evadesNadiya M. Teplyuk · 2011 · Journal of Cellular Biochemistry
- EZH2 orchestrates apicobasal polarity and neuroepithelial cell renewalNaiara Akizu, Marian A. Martínez‐Balbás · 2016 · Neurogenesis
- Epigenetic regulation of enhancer of zeste homolog 2 (EZH2) -Yin Yang 1 (YY1) axis in cancerNikhil Chandnani, Ishika Gupta, Vidhi Thakkar, Koustav Sarkar · 2023 · Pathology - Research and Practice
- A senescence restriction point acting on chromatin integrates oncogenic signalsStéphane Lopes‐Paciencia, Véronique Bourdeau, Marie‐Camille Rowell, Davoud Amirimehr, Jordan Guillon, Paloma Kalegari, Arnab Barua, Vincent Quoc‐Huy Trinh, Féryel Azzi, Simon Turcotte et al. · 2024 · Cell Reports
- High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobesHyun Ji An, Yun Kim, Soojeong Chang, Hakchun Kim, Jihwan Song, Hyunsung Park, Inhee Choi · 2021 · Nature Communications
- Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunctionM.S. Misale, Linda Witek Janusek, Dina Tell, Herbert L. Mathews · 2017 · Brain Behavior and Immunity
- Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviorsYuen Gao, Natalia Duque‐Wilckens, Mohammad B. Aljazi, Adam James Moeser, George I. Mias, Alfred Jay Robison, Yi Zhang, Jin He · 2022 · iScience
- An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAsDebora Bencivenga, Emanuela Stampone, Angela Vastante, Myassar Barahmeh, Fulvio Della Ragione, Adriana Borriello · 2022 · Cells
- Targeting immunosenesence promotes clearance of senescent cellsAnteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier Cexus · 2025 · Immunity & Ageing
- G1/S arrest: a key mechanism of cellular aging and replicative senescence李向东, Xin Yan, Qi Chen, Sui Mai · 2026 · Biogerontology
- Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblastsMasayuki Harada, Kanae Su-Harada, Takeshi Kimura, Koh Ono, Noboru Ashida · 2024 · Cell Cycle
- Lysine methylation modifications in tumor immunomodulation and immunotherapy: regulatory mechanisms and perspectivesYiming Luo, Junli Lu, Zhen Lei, He Zhu, Dean Rao, Tiantian Wang, Chenan Fu, Zhiwei Zhang, Limin Xia, Wenjie Huang · 2024 · Biomarker Research
- Systematic transcriptomic analysis and temporal modelling of human fibroblast senescenceRebekah-Louise Scanlan, L. Pease, Hannah O’Keefe, Alvaro Martinez Guimera, Lene Juel Rasmussen, James Wordsworth, Daryl P. Shanley · 2024 · Frontiers in Aging
- Hematopoiesis during development, aging, and diseaseJohannes Jung, Sonja C. Buisman, Gerald de Haan · 2016 · Experimental Hematology
- Role of Polycomb Complexes in Normal and Malignant Plasma CellsE. Varlet, Sara Ovejero, Anne-Marie Martinez, Giacomo Cavalli, J. Moreaux · 2020 · International Journal of Molecular Sciences
- Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasisYifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah D. Coughlan, Pedro L. Baldoni, Nicolas Jacquelot, Wang H. J. Cao, Simon Preston, Cynthia Louis, Jai Rautela et al. · 2021 · Science Immunology
- Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiersGregory David · 2012 · Cancer Biology & Therapy
- Senescence and Senescence-Related DisordersZhiwei Peter Wang, Hiroyuki Inuzuka · 2013 · InTech eBooks
- Molecular Mechanisms of Hepatocellular CarcinomaHani Alotaibi, Neşe Atabey, M. Kasim Diril, Esra Erdal, Mehmet Öztürk · 2016 · Springer eBooks
- Senescence‐associated transcriptional derepression in subtelomeres is determined in a chromosome‐end‐specific mannerMartin Rey‐Millet, Mélanie Pousse, Chan Soithong, Jing Ye, Aarón Méndez-Bermúdez, Éric Gilson · 2023 · Aging Cell
- The use of human tumour cell lines in the discovery of new cancer chemotherapeutic drugsBruce C. Baguley, Elaine S Marshall · 2008 · Expert Opinion on Drug Discovery
- lncRNAMalat1and miR-26 cooperate in the regulation of neuronal progenitor cell proliferation and differentiationNina Was, Mark Sauer, Utz Fischer, Matthias Becker · 2022 · RNA
- The epigenetic regulation of cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrenceChristiana O. Appiah, Manjulata Singh, Lauren May, Ishita Bakshi, Ashish Vaidyanathan, Paul Dent, Gordon D. Ginder, Steven Grant, Harry D. Bear, Joseph W. Landry · 2023 · Advances in cancer research
- Downregulation of EZH2 inhibits epithelial–mesenchymal transition in enzalutamide‐resistant prostate cancerZhuangzhuang Zhang, Xinyi Wang, Miyeong Kim, Daheng He, Chi Wang, Ka-wing Fong, Xiaoqi Liu · 2023 · The Prostate
- The putative tumor suppressor gene EphA7 is a novel BMI-1 targetGaëlle Prost, Sebastian Benedict Braun, Falk Hertwig, Marcus Winkler, Lucas Jagemann, Sara Nolbrant, Isabelle V. Leefa Chong San, Nils Offen, Kenichi Miharada, Stefan Lang et al. · 2016 · Oncotarget
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- Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC)Nikhil Chandnani, Vedika Shrirang Choudhari, Rajat Talukdar, Sudeshna Rakshit, Geetha Shanmugam, Shiuli Guchait, Ishika Gupta, Melvin George, Koustav Sarkar · 2023 · Medical Oncology
- An INKlination for epigenetic control of senescenceGordon G. Peters · 2008 · Nature Structural & Molecular Biology
- Targeting the Perpetrator: Breast Cancer Stem Cell TherapeuticsArindam Pal, Kelli Elizabeth Valdez, Martha Z. Carletti, Fariba Behbod · 2010 · Current Drug Targets
- MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescenceRaphaël M. Culerrier, M. Carraz, Carl Mann, Malek Djabali · 2016 · Molecular Biology of the Cell
- B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancerQi Cao, Qipeng Liu, Qiaqia Li, Sen Lin Zhu, Yi Yang · 2018 · Asian Journal of Andrology
- Long Noncoding RNA ANROC on the INK4 Locus Functions to Suppress Cell ProliferationYojiro Kotake, TAKESHI TSURUDA · 2020 · Cancer Genomics & Proteomics
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- Probing the Scope and Mechanisms of Calcitriol Actions Using Genetically Modified Mouse ModelsDengshun Miao, David Goltzman · 2020 · JBMR Plus
- Epigenetic Regulation of Cancer Stem Cell Gene ExpressionSharmila A. Bapat · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
- DAMD to epigenetic silenceT. Kelly, Peter A. Jones · 2009 · Proceedings of the National Academy of Sciences
- Chromosomal rearrangements in PLAG1 of myoepithelial salivary gland tumours.Reinhard Edgar Friedrich, Julia Dilcher, Michael Jaehne, Thomas Löning · 2012 · PubMed
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- Genetic Determinants of Cancer SusceptibilityJoe M. Angel, Erika L. Abel, John DiGiovanni · 2010 · Elsevier eBooks
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- Unraveling the Mysteries of Aging Through a Hutchinson–Gilford Progeria Syndrome ModelRyan N. Serio · 2011 · Rejuvenation Research
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- Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in miceYuchi Zhang, Dongwei Han, Pengyang Yu, Qijing Huang, Pengling Ge · 2017 · Experimental and Therapeutic Medicine
- Polycomb Repressive Complex 2: a Dimmer Switch of Gene Regulation in Calvarial Bone DevelopmentTimothy E Nehila, James W. Ferguson, Radhika P. Atit · 2020 · Current Osteoporosis Reports
- Epigenetic Drift and AgingEster Lara, Vincenzo Calvanese, Mario F. Fraga · 2009 · Springer eBooks
- Molecular targets for NF1-associated malignant peripheral nerve sheath tumorLama Binobaid, Michał M. Masternak · 2020 · Reports of Practical Oncology & Radiotherapy
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- Structural Aspects of Small-Molecule Inhibition of Methyllysine Reader ProteinsNatalia Milosevich, Zoey Warmerdam, Fraser A. Hof · 2016 · Future Medicinal Chemistry
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