The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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3. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic β-cell proliferation
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4. Mechanisms of transcriptional repression by histone lysine methylation
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5. PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping
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6. Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective
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7. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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8. Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health
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9. Bone Aging, Cellular Senescence, and Osteoporosis
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10. Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
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11. Gene regulatory programmes of tissue regeneration
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12. Chromatin structure as a mediator of aging
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13. Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
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14. EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/ CDKN1A Expression
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15. Targeting Histone Demethylases: A New Avenue for the Fight against Cancer
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16. Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
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17. Epigenetic regulation of caloric restriction in aging
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18. Regulation, functions and transmission of bivalent chromatin during mammalian development
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19. Assessing cell and organ senescence biomarkers
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20. P16INK4A—More Than a Senescence Marker
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21. Cancer and ageing: convergent and divergent mechanisms
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22. Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks
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23. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
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24. The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
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25. EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1 , CLU , RUNX3 , and NGFR
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26. Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
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27. Attributes of adult stem cells
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28. Senescence in Post-Mitotic Cells: A Driver of Aging?
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29. Cancer Chemoprevention by Targeting the Epigenome
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30. An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences
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31. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype
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32. Regulation of senescence traits by MAPKs
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33. EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
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34. Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation
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35. Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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36. CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells
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37. PRC1 complex diversity: where is it taking us?
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38. Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
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39. MLL1 is essential for the senescence-associated secretory phenotype
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40. Ubiquitin‐specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
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41. Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer
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42. Non-coding RNAs: key regulators of mammalian transcription
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43. Oxidative stress, cellular senescence and ageing
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44. The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
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45. CBX7 is a tumor suppressor in mice and humans
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46. Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells
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47. Epigenetic Regulation of Cellular Senescence and Aging
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48. Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
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49. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
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50. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
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51. The histone demethylase UTX enables RB-dependent cell fate control
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52. Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4
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53. Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability
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54. Methylation across the central dogma in health and diseases: new therapeutic strategies
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55. Deletion of the Polycomb-Group Protein EZH2 Leads to Compromised Self-Renewal and Differentiation Defects in Human Embryonic Stem Cells
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56. Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2
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57. Emerging roles for Polycomb proteins in cancer
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58. Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
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59. Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells
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60. The Chromatin Landscape of Cellular Senescence
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61. A central role for canonical PRC1 in shaping the 3D nuclear landscape
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62. Chromatin remodeling in Cancer: A Gateway to regulate gene Transcription
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63. Genomic insights into cancer-associated aberrant CpG island hypermethylation
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64. SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells
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65. New Insights into the Role of Histone Changes in Aging
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66. The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
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67. Epigenetic regulation of aging stem cells
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68. EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer
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69. Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice
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70. Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
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71. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
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73. Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
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75. Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
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76. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
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77. Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells
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78. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a / Arf locus
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79. PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
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80. Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer
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81. A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations
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82. Crosstalk among Epigenetic Pathways Regulates Neurogenesis
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83. Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription
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84. JMJD3 in the regulation of human diseases
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85. Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging
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86. Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells
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87. Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells
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89. Interpretation of Developmental Signaling at Chromatin: The Polycomb Perspective
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92. Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells
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93. Molecular pathways and targets in prostate cancer
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94. Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells
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95. Cellular senescence: a promising strategy for cancer therapy
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96. Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells
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97. BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
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98. Epigenetic Control of Aging
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99. Cellular senescence: Its role in tumor suppression and aging
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100. Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications
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