Cited by 850Epigenetics and DNA MethylationTelomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Open access

Abstract

The p16 INK4A and p14 ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show that the ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex. Significantly, EZH2 is down-regulated in stressed and senescing populations of cells, coinciding with decreased levels of associated H3K27me3, displacement of BMI1, and activation of transcription. These results provide a model for how the INK4A-ARF locus is activated and how Polycombs contribute to cancer.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gad.415507

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 40 references

Cited by

Sorted by citations

Items 501–600 of 849

Metadata

Authors
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., Hansen, K. H., & Helin, K.
Affiliations
  • University of Copenhagen (DK)
  • European Institute of Oncology (IT)
  • Vlaams Instituut voor Biotechnologie (BE)
Venue
Genes & Development
Published
2007-03-01
Volume
21
Issue
5
Pages
525-530
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2101370480
Cited by
850
References
40
Citations by year
2026: 16 · 2025: 14 · 2024: 20 · 2023: 26 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 30 · 2018: 32 · 2017: 50 · 2016: 76 · 2015: 48 · 2014: 48 · 2013: 55 · 2012: 58
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
  • Kræftens Bekæmpelse
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Lundbeckfonden (R9-2007-978)
  • Novo Nordisk
  • Novo Nordisk Fonden
  • Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
Polycomb group proteins, INK4a/ARF locus, p16INK4a, p14ARF, cellular senescence, BMI1, EZH2, polycomb repressive complex 2, H3K27me3, chromatin repression, transcriptional activation, cancer
MeSH terms
Enhancer of Zeste Homolog 2 Protein, Animals, Cell Line, DNA-Binding Proteins, Embryo, Mammalian, Fibroblasts, Histones, Humans, Methylation, Mice, Inbred C57BL, Neoplasms, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Proteins, Proto-Oncogene Proteins, Repressor Proteins, Stem Cells, Transcription Factors, Down-Regulation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Genes, p16, Oligonucleotide Array Sequence Analysis, Tumor Suppressor Protein p14ARF, Chromatin Immunoprecipitation, Mice, Polycomb Repressive Complex 1, Polycomb Repressive Complex 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review