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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Open accessAbstract
The p16 INK4A and p14 ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show that the ability of the oncogene BMI1 to repress the INK4A-ARF locus requires its direct association and is dependent on the continued presence of the EZH2-containing Polycomb-Repressive Complex 2 (PRC2) complex. Significantly, EZH2 is down-regulated in stressed and senescing populations of cells, coinciding with decreased levels of associated H3K27me3, displacement of BMI1, and activation of transcription. These results provide a model for how the INK4A-ARF locus is activated and how Polycombs contribute to cancer.
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“The molecular mechanisms underlying this derepression are not completely understood but have been associated with loss of polycomb group of proteins but independent of p53 (Jacobs et al., 1999; Bracken et al., 2007).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Bracken et al., 2007
Experimental — accuracy not yet measuredIn the citing paper
“During senescence, PRC delocalization from the CDKN2A locus, transcriptional downregulation of EZH2 [83], and recruitment of JMJD3 [84,85], a histone lysine demethylase that catalyzes H3K27 demethylation, lead to removal of the repressive H3K27me3 mark at the CDKN2A locus and facilitate p16 transcription.”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [83]
In the citing paper
“The mechanistic details of how this happens are starting to emerge, and seem in part to involve the progressive loss of repressive Polycomb complexes 7”
From The common biology of cancer and ageing (2007) · cites this paper as [7]
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 1×
“SA- -gal assays were performed as previously described (Narita et al. 2003).”
MethodA gene hypermethylation profile of human cancer.
Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,317
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,286
Self-citationEZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
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Oncogenic senescence: a multi-functional perspective
Baker, D. J., Alimirah, F., van Deursen, J. M., Campisi, J., & Hildesheim, J. (2017) · Oncotarget · doi:10.18632/oncotarget.15742 · Cited by 49
Chu, L., Qu, Y.-X., An, Y., Hou, L., Li, J., Li, W., Fan, G., Song, B., Li, E., Zhang, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04601-6 · Cited by 47
Wang, Y., Alla, V., Goody, D., Gupta, S. K., Spitschak, A., Olaf Wolkenhauer, A., Pützer, B. M., & Engelmann, D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv885 · Cited by 45
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Cooney, T. M., Lubanszky, E., Prasad, R., Hawkins, C. E., & Mueller, S. (2020) · Journal of Neuro-Oncology · doi:10.1007/s11060-020-03553-1 · Cited by 46
Belle, J. I., & Nijnik, A. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.004 · Cited by 46
Compositional and functional diversity of canonical PRC1 complexes in mammals
Connelly, K. E., & Dykhuizen, E. C. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.12.006 · Cited by 47
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Wang, T., Huang, S., & He, C. (2022) · Cell Proliferation · doi:10.1111/cpr.13323 · Cited by 47
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Cellular senescence: from anti-cancer weapon to anti-aging target
Yuan, L., Alexander, P. B., & Wang, X. (2020) · Science China Life Sciences · doi:10.1007/s11427-019-1629-6 · Cited by 42
Wang, J., Yang, L., Dong, C., Wang, J., Xu, L., Qiu, Y., Weng, Q., Zhao, C., Xin, M., & Lu, Q. R. (2020) · Science Advances · doi:10.1126/sciadv.aaz6477 · Cited by 43
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Saratsis, A. M., Knowles, T., Petrović, A., & Nazarian, J. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad164 · Cited by 52
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Strauss, R., Hamerlik, P., Lieber, A., & Bartek, J. (2012) · Molecular Therapy · doi:10.1038/mt.2012.2 · Cited by 41
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Ron, D., Fuchs, Y., & Chorev, D. S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.03.013 · Cited by 41
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Blair, L. P., & Yan, Q. (2012) · DNA and Cell Biology · doi:10.1089/dna.2012.1654 · Cited by 41
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He, S., Tong, Q., Bishop, D. K., & Zhang, Y. (2013) · Immunotherapy · doi:10.2217/imt.13.101 · Cited by 41
Vékony, H., Raaphorst, F. M., Otte, A. P., van Lohuizen, M., Leemans, C. R., van der Waal, I., & Bloemena, E. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.054262 · Cited by 41
Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury
Ma, K. H., Duong, P., Moran, J. J. M., Junaidi, N., & Svaren, J. P. (2018) · Glia · doi:10.1002/glia.23500 · Cited by 41
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Fei, M., Sun, H., Wang, B., Ahmad, N., Guo, H., Gao, H., Gao, Y., Liu, X., & Li, H. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173214 · Cited by 41
Nawaz, Z., Patil, V., Arora, A., Hegde, A. S., Arivazhagan, A., Santosh, V., & Somasundaram, K. (2016) · Scientific Reports · doi:10.1038/srep27753 · Cited by 40
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Jackstadt, R., Jung, P., & Hermeking, H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.282 · Cited by 41
Dong, Q., Oh, J.-E., Chen, W., Kim, R. Y., Kim, R. H., Shin, K.-H., McBride, W. H., Park, N.-H., & Kang, M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.11 · Cited by 40
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Ferraro, A. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0276-6 · Cited by 42
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Fitieh, A. M., Locke, A. J., Motamedi, M., & Ismail, I. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062976 · Cited by 43
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Brien, G. L., Healy, E., Jerman, E., Conway, E., Fadda, E., O’Donovan, D., Krivtsov, A. V., Rice, A. M., Kearney, C. J., Flaus, A., et al. (2015) · Genes & Development · doi:10.1101/gad.267930.115 · Cited by 42
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Simboeck, E., Gutiérrez, A., Cozzuto, L., Beringer, M., Caizzi, L., Keyes, W. M., & Croce, L. D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.159 · Cited by 39
Ueda, K., Yoshimi, A., Kagoya, Y., Nishikawa, S., Márquez, V. E., Nakagawa, M. M., & Kurokawa, M. (2014) · Cancer Science · doi:10.1111/cas.12386 · Cited by 39
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Kim, H.-G., Kim, D. J., Li, S., Lee, K. Y., Li, X., Bode, A. M., & Dong, Z. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.360362 · Cited by 39
p53 Binds to and Is Required for the Repression of Arf Tumor Suppressor by HDAC and Polycomb
Zeng, Y., Kotake, Y., Pei, X., Smith, M. D., & Xiong, Y. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3483 · Cited by 41
Sakaki, M., Ebihara, Y., Okamura, K., Nakabayashi, K., Igarashi, A., Matsumoto, K., Hata, K., Kobayashi, Y., & Maehara, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171431 · Cited by 39
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Sousa‐Franco, A., Rebelo, K., da Rocha, S. T., & de Jesus, B. B. (2018) · Aging Cell · doi:10.1111/acel.12870 · Cited by 38
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Benitz, S., Straub, T., Mahajan, U. M., Mutter, J., Czemmel, S., Unruh, T., Wingerath, B., Deubler, S., Fahr, L., Cheng, T., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317208 · Cited by 39
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Sienkiewicz, M., Sroka, K., Binienda, A., Jurk, D., & Fichna, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102083 · Cited by 39
Yamazaki, H., Mori, T., Yazawa, M., Maeshima, A. M., Matsumoto, F., Yoshimoto, S., Ota, Y., Kaneko, A., Tsuda, H., & Kanai, Y. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.120 · Cited by 38
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Poynter, S. T., & Kadoch, C. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.244 · Cited by 43
Zhao, Q., Qian, Q., Cao, D., Yang, J., Gui, T., & Shen, K. (2018) · Journal of Ovarian Research · doi:10.1186/s13048-018-0406-z · Cited by 38
Yi, J., Shi, X., Xuan, Z., & Wu, J. I. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.031 · Cited by 37
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Pitto, L., Rizzo, M., Simili, M., Colligiani, D., Evangelista, M., Mercatanti, A., Mariani, L., Cremisi, F., & Rainaldi, G. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00085.2009 · Cited by 38
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Martin, N., Popov, N., Aguiló, F., O’Loghlen, A., Raguz, S., Snijders, A. P., Dharmalingam, G., Li, S., Thymiakou, E., Carroll, T. D., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.37 · Cited by 36
Ueno, K., Iwagawa, T., Kuribayashi, H., Baba, Y., Nakauchi, H., Murakami, A., Nagasaki, M., Suzuki, Y., & Watanabe, S. (2016) · Scientific Reports · doi:10.1038/srep29264 · Cited by 39
Zhao, Z., Dong, Q., Liu, X., Wei, L., Liu, L., Li, Y., & Wang, X. (2020) · Genomics · doi:10.1016/j.ygeno.2019.07.020 · Cited by 37
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Robson, L. G., Foggia, V. D., Radunović, A., Bird, K., Zhang, X., & Marino, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027116 · Cited by 38
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Negishi, M., Saraya, A., Mochizuki, S., Helin, K., Koseki, H., & Iwama, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012373 · Cited by 37
Self-citationDecottignies, A., & di Fagagna, F. D. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.003 · Cited by 37
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Robin, J. D., & Magdinier, F. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00153 · Cited by 39
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Gallardo, A., Molina, A., Asenjo, H. G., López-Onieva, L., Martorell‐Marugán, J., Espinosa-Martínez, M., Griñán‐Lisón, C., Álvarez-Pérez, J. C., Cara, F. E., Navarro-Marchal, S. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02375-x · Cited by 39
Nakade, K., Pan, J., Yamasaki, T., Murata, T., Wasylyk, B., & Yokoyama, K. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808333200 · Cited by 36
O’Hara, S. P., Splinter, P. L., Trussoni, C. E., Pisarello, M. J. L., Loarca, L., Splinter, N. S., Schutte, B. F., & LaRusso, N. F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.777409 · Cited by 36
At the stem of youth and health
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Ko, A., Han, S. Y., & Song, J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.11.120 · Cited by 35
Huang, Q., He, S., Tian, Y., Gu, Y., Chen, P., Li, C., Huang, J., Liu, Y., Yu, H., Jin, M., et al. (2017) · Blood · doi:10.1182/blood-2016-08-735886 · Cited by 35
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Koike, H., Ouchi, R., Ueno, Y., Nakata, S., Obana, Y., Sekine, K., Zheng, Y., Takebe, T., Isono, K., Koseki, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104776 · Cited by 34
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Parker, M. H. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00059 · Cited by 34
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Xiang, H., Yuan, L., Gao, X., Alexander, P. B., Lopez, O. M., Lau, C. E., Ding, Y., Chong, M., Sun, T., Chen, R., et al. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.19 · Cited by 33
Serebryannyy, L., & Misteli, T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201706061 · Cited by 37
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Dai, X., Zhang, Q., Yu, Z., Sun, W., Wang, R., & Miao, D. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23325 · Cited by 35
Gao, T., Lin, M., Shao, B., Zhou, Q., Wang, Y., Chen, X., Zhao, D., Dai, X., Shen, C., Cheng, H., et al. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1779471 · Cited by 34
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Woźniak, M., & Czyż, M. (2021) · Cancers · doi:10.3390/cancers13194848 · Cited by 39
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Fog, C. K., Jensen, K. T., & Lund, A. H. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_776.xml.x · Cited by 35
Histone demethylase JMJD3 at the intersection of cellular senescence and cancer
Perrigue, P. M., Najbauer, J., & Barciszewski, J. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.03.002 · Cited by 35
EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21
Akizu, N., García, M. A., Estarás, C., Fueyo, R., Badosa, C., de la Cruz, X., & Martínez‐Balbás, M. A. (2016) · Open Biology · doi:10.1098/rsob.150227 · Cited by 33
Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development
Snitow, M. E., Lu, M., Cheng, L., Zhou, S., & Morrisey, E. E. (2016) · Development · doi:10.1242/dev.134932 · Cited by 33
CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1
Yu, T., Wu, Y., Hu, Q., Zhang, J., Nie, E., Wu, W., Wang, X., Wang, Y., & Liu, N. (2017) · Oncotarget · doi:10.18632/oncotarget.15789 · Cited by 33
Bmi1 Promotes Erythroid Development Through Regulating Ribosome Biogenesis
Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young-Baird, S. K., Soltis, A. R., Yu, M., Vemula, S., et al. (2014) · Stem Cells · doi:10.1002/stem.1896 · Cited by 36
Transcriptional and epigenetic networks in haematological malignancy
Cheung, N., & So, C. W. E. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.068 · Cited by 36
B-MYB delays cell aging by repressing p16 INK4α transcription
Huang, Y., Wu, J., Li, R., Wang, P., Han, L., Zhang, Z., & Tong, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0501-9 · Cited by 34
Context-specific regulation of cancer epigenomes by histone and transcription factor methylation
Sarris, M. E., Nikolaou, K., & Talianidis, I. (2013) · Oncogene · doi:10.1038/onc.2013.87 · Cited by 33
Kosalai, S. T., Morsy, M. H. A., Papakonstantinou, N., Mansouri, L., Stavroyianni, N., Kanduri, C., Σταματόπουλος, Κ., Rosenquist, R., & Kanduri, M. (2019) · Epigenetics · doi:10.1080/15592294.2019.1633867 · Cited by 32
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Bashyam, M. D., Animireddy, S., Bala, P., Naz, A., & George, S. A. (2019) · Gene · doi:10.1016/j.gene.2019.04.025 · Cited by 31
E2f6 and Bmi1 cooperate in axial skeletal development
Courel, M., Friesenhahn, L., & Lees, J. A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21516 · Cited by 34
The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion
Healy, E., Zhang, Q., Gail, E. H., Agius, S. C., Sun, G., Bullen, M. J., Pandey, V., Das, P. P., Polo, J. M., & Davidovich, C. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113858 · Cited by 31
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Avrahami, D., & Kaestner, K. H. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.06.002 · Cited by 33
Wu, K. (2011) · PubMed · Cited by 32
Khan, M., Walters, L. L., Li, Q., Thomas, D. G., Miller, J. M. L., Zhang, Q., Sciallis, A. P., Liu, Y., Dlouhy, B. J., Fort, P. E., et al. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.104 · Cited by 31
A, P., Xu, X., Wang, C., Yang, J., Wang, S., Dai, J., & Ye, L. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0213-1 · Cited by 30
Vékony, H., Röser, K., Löning, T., Raaphorst, F. M., Leemans, C. R., van der Waal, I., & Bloemena, E. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03184.x · Cited by 30
Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., & Takihara, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011054107 · Cited by 29
Dong, P., Ihira, K., Hamada, J., Watari, H., Yamada, T., Hosaka, M., Hanley, S. J. B., 工藤, 正., & Sakuragi, N. (2015) · Oncotarget · doi:10.18632/oncotarget.4847 · Cited by 30
Metadata
- Authors
- Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., Hansen, K. H., & Helin, K.
- Affiliations
- University of Copenhagen (DK)
- European Institute of Oncology (IT)
- Vlaams Instituut voor Biotechnologie (BE)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-03-01
- Volume
- 21
- Issue
- 5
- Pages
- 525-530
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC1820894
- OpenAlex
- W2101370480
- Cited by
- 850
- References
- 40
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 20 · 2023: 26 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 30 · 2018: 32 · 2017: 50 · 2016: 76 · 2015: 48 · 2014: 48 · 2013: 55 · 2012: 58
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Kræftens Bekæmpelse
- Sundhed og Sygdom, Det Frie Forskningsråd
- Lundbeckfonden (R9-2007-978)
- Novo Nordisk
- Novo Nordisk Fonden
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Polycomb group proteins, INK4a/ARF locus, p16INK4a, p14ARF, cellular senescence, BMI1, EZH2, polycomb repressive complex 2, H3K27me3, chromatin repression, transcriptional activation, cancer
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Animals, Cell Line, DNA-Binding Proteins, Embryo, Mammalian, Fibroblasts, Histones, Humans, Methylation, Mice, Inbred C57BL, Neoplasms, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Proteins, Proto-Oncogene Proteins, Repressor Proteins, Stem Cells, Transcription Factors, Down-Regulation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Genes, p16, Oligonucleotide Array Sequence Analysis, Tumor Suppressor Protein p14ARF, Chromatin Immunoprecipitation, Mice, Polycomb Repressive Complex 1, Polycomb Repressive Complex 2
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