The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio +4 more·2007·Genes & Development

DOI 10.1101/gad.415507

Cited by (850)

Items 301–400 of 850

Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human
Shivani Malik, Sukesh R. Bhaumik · 2010 · FEBS Journal
Defining the toxicology of aging
Jessica A. Sorrentino, Hanna Kelly Sanoff, Norman E. Sharpless · 2014 · Trends in Molecular Medicine
Role for the MOV10 RNA helicase in Polycomb-mediated repression of the INK4a tumor suppressor
Selma El Messaoudi, James Nicholls, Goedele N. Maertens, Sharon Brookes, Emily Bernstein, Gordon G. Peters · 2010 · Nature Structural & Molecular Biology
Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle
Vincent A. Blomen, Johannes Boonstra · 2010 · Cellular and Molecular Life Sciences
EZH2 Represses Target Genes through H3K27-Dependent and H3K27-Independent Mechanisms in Hepatocellular Carcinoma
Shu-Bin Gao, Qi‐Fan Zheng, Bin Xu, Chang-Bao Pan, Kang‐Li Li, Yue Zhao, Qilin Zheng, Xiao Lin, Lixiang Xue, Guang‐Hui Jin · 2014 · Molecular Cancer Research
Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets
Vijay R. Dondeti, Bradley Stephen Wubbenhorst, Priti Lal, John Dozier Gordan, Kurt P D'Andrea, Edward F. Attiyeh, Marie Celeste Simon, Katherine L. Nathanson · 2011 · Cancer Research
Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways
Thomas Thurnherr, Way-Champ Mah, Zhengdeng Lei, Jin Hui Yu, Steve Rozen, Caroline Guat Lay Lee · 2016 · Scientific Reports
Enhancer of Zeste Homolog 2 (EZH2) Promotes Progression of Cholangiocarcinoma Cells by Regulating Cell Cycle and Apoptosis
Shigeki Nakagawa, Hirohisa Okabe, Yasuo Sakamoto, Hiromitsu Hayashi, Daisuke Hashimoto, Naomi Yokoyama, Keita Sakamoto, Hideyuki Kuroki, Kosuke Mima, Hidetoshi Nitta et al. · 2013 · Annals of Surgical Oncology
Regulation of senescence escape by the cdk4–EZH2–AP2M1 pathway in response to chemotherapy
Mélanie Le Duff, Julien Gouju, Barbara Jonchère, Jordan Guillon, Bertrand Toutain, Alice Boissard, Cécile Henry, Catherine Guette, Eric Lelièvre, Olivier Coqueret · 2018 · Cell Death and Disease
Noncanonical NF-κB in Cancer
Matthew Tegowski, Albert S. Baldwin · 2018 · Biomedicines
Polycomb proteins in hematologic malignancies
Martin-Perez, Daniel, Piris, Miguel A., Sanchez-Beato, Margarita · 2010 · Blood
Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming
Radhika Arasala Rao, Narendra Dhele, Sabna Cheemadan, Alhad Ashok Ketkar, Giridhara Rao Jayandharan, Dasaradhi Palakodeti, Shravanti Rampalli · 2015 · Scientific Reports
EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma
Qian Chen, Peng‐Sheng Zheng, Wenting Yang · 2016 · Oncotarget
Emerging roles of lnc RNA s in senescence
Marta Montes, Anders Henrik Lund · 2016 · FEBS Journal
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer
Yong Yu, Jingjing Qi, Jieyi Xiong, Liping Jiang, Di Cui, Junlin He, Ping Chen, Lianjie Li, Chenjie Wu, Tonghui Ma et al. · 2019 · Theranostics
Histone H2B ubiquitination: the cancer connection
Joaquin Maximiliano Espinosa · 2008 · Genes & Development
Polycomb proteins in mammalian cell differentiation and plasticity
Carolina Prezioso, Valerio Orlando · 2011 · FEBS Letters
Targeting EZH2 for Cancer Therapy: Progress and Perspective
Chi Han Li, Yangchao Chen · 2015 · Current Protein and Peptide Science
The Multiple Facets of PRC2 Alterations in Cancers
Michel Adam Wassef, Raphaël Margueron · 2016 · Journal of Molecular Biology
Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent Modifications
Yang Jiao, Yunpeng Feng, Xiuli Wang · 2018 · Biochemistry (Moscow)
1,25‐Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice
Lulu Chen, Renlei Yang, Wanxin Qiao, Xiaoqin Yuan, Shui Wang, David Goltzman, Dengshun Miao · 2018 · International Journal of Cancer
Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9
Marie L. Harth-Hertle, Barbara A. Scholz, Florian Erhard, Laura V. Glaser, Lars Dölken, Ralf Zimmer, Bettina Kempkes · 2013 · PLoS Pathogens
Reprogramming of human cancer cells to pluripotency for models of cancer progression
Jungsun Kim, Kenneth S. Zaret · 2015 · The EMBO Journal
Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus
Yan Liu, Fan Liu, Hao Yu, Xinyang Zhao, Goro Sashida, A DeBlasio, Michael W. Harr, Qing‐Bai She, Zhenbang Chen, Hui‐Kuan Lin et al. · 2012 · Science Signaling
The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma
Shu-Bin Gao, Bin Xu, Lihong Ding, Qilin Zheng, Li Zhang, Qi‐Fan Zheng, Shan-Hua Li, Zi-Jie Feng, Jie Wei, Zhenyu Yin et al. · 2014 · Journal of Hepatology
Current Status and Issues in Cancer Stem Cell Study
Ying Yang, Jared Chang · 2008 · Cancer Investigation
HBP1-Mediated Transcriptional Regulation of DNA Methyltransferase 1 and Its Impact on Cell Senescence
Kewu Pan, Yi‐Fan Chen, Mendel M. Roth, Weibin Wang, Shuya Wang, Amy S. Yee, Xiaowei Zhang · 2012 · Molecular and Cellular Biology
NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2
Gian Marco De Donatis, Elodie Le Pape, Anne Pierron, Yann Chéli, Véronique Hofman, Paul M Hofman, M Allegra, Katia Zahaf, Philippe Bahadoran, Stéphane Rocchi et al. · 2015 · Oncogene
Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
Anthony M. Battram, Mireia Bachiller, Beatriz Martín-Antonio · 2020 · International Journal of Molecular Sciences
SOX9, a potential tumor suppressor in cervical cancer, transactivates p21WAF1/CIP1 and suppresses cervical tumor growth
Haiyan Wang, Lian Ping, Peng‐Sheng Zheng · 2015 · Oncotarget
Polycomb CBX7 Directly Controls Trimethylation of Histone H3 at Lysine 9 at the p16 Locus
Qiang Li, Xiuhong Wang, Zheming Lu, Baozhen Zhang, Zhenpo Guan, Zhaojun Liu, Qiming Zhong, Liankun Gu, Jing Zhou, Budong Zhu et al. · 2010 · PLoS ONE
The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?
Andrea Scelfo, Andrea Piunti, Diego Pasini · 2014 · FEBS Journal
DNA methylation, ageing and the influence of early life nutrition
Karen A. Lillycrop, Samuel P. Hoile, Leonie R. Grenfell, Graham C. Burdge · 2014 · Proceedings of The Nutrition Society
Real-time in vivo imaging of p16Ink4a gene expression: a new approach to study senescence stress signaling in living animals
Naoko Ohtani, Kimi Yamakoshi, Akiko Takahashi, Eiji Hara · 2010 · Cell Division
DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration
Kaji, Kosuke, Factor, Valentina M., Andersen, Jesper B., Durkin, Marian E., Tomokuni, Akira, Marquardt, Jens U., Matter, Matthias S., Hoang, Tanya, Conner, Elizabeth A., Thorgeirsson, Snorri S. · 2016 · Hepatology
Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence
Stephan Gebel, Rosemarie B. Lichtner, Brian P. Frushour, Walter K. Schlage, Vy Hoang, Marja Talikka, Arnd Hengstermann, Carole Mathis, Emilija Veljkovic, Michael J. Peck et al. · 2013 · Bioinformatics and Biology Insights
Regulating Methylation at H3K27: A Trick or Treat for Cancer Cell Plasticity
Provas Das, Joseph H. Taube · 2020 · Cancers
The Polycomb Protein Ezh2 Impacts on Induced Pluripotent Stem Cell Generation
Xiaolei Ding, Xiaoying Wang, Stephanie Sontag, Jie Qin, Paul Wanek, Qiong Lin, Martin Zenke · 2013 · Stem Cells and Development
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Jennifer B. Inloes, Erinn B. Rankin, Huafeng Xie, Ernestina Schipani, Stuart H. Orkin, Tatsuya Kobayashi · 2016 · Nature Communications
Tissue-specific p19 Arf regulation dictates the response to oncogenic K-ras
Nathan P. Young, Tyler Jacks · 2010 · Proceedings of the National Academy of Sciences
Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma
Junpei Yamaguchi, Motoko Sasaki, Yasunori Sato, Keita Itatsu, Kenichi Harada, Yoh Zen, Hiroko Ikeda, Yuji Nimura, Masato Nagino, Yasuni Nakanuma · 2009 · Cancer Science
Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development
Katherine L. Dauber, Carolina N. Perdigoto, Víctor Julián Valdés, Francis J. Santoriello, Idan Cohen, Elena Ezhkova · 2016 · Journal of Investigative Dermatology
Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
Josie X. Zhou, Sangeeta Dhawan, Hualin Fu, Emily Snyder, Rita Bottino, Sharmistha Kundu, Seung K. Kim, Anil Bhushan · 2013 · Journal of Clinical Investigation
Cellular signaling in normal and cancerous stem cells
Edgar Grinstein, Peter Wernet · 2007 · Cellular Signalling
c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression
Hui Yi Kua, Huijuan Liu, Wai Fook Leong, Lili Li, Deyong Jia, Gang Ma, Yuanyu Hu, Xueying Wang, Jenny F. L. Chau, Ye‐Guang Chen et al. · 2012 · Nature Cell Biology
Chromatin modifications: The driving force of senescence and aging?
Teresa DiMauro, Gregory David · 2009 · Aging
Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells
Armelle Corpet, Manuel Stucki · 2014 · Chromosoma
Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis
Richard Marcotte, Harvey W. Smith, Virginie Sanguin‐Gendreau, Rosalie Victoria McDonough, William J. Muller · 2011 · Proceedings of the National Academy of Sciences
Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge
Jose Antonio Gomez-Sanchez, Clara Gomis-Coloma, Cruz Morenilla‐Palao, Gloria Peiró, Eduard Serra, Manuel Serrano, Hugo Cabedo · 2013 · Brain
Signaling epigenetics: Novel insights on cell signaling and epigenetic regulation
Rodrigo G. Arzate‐Mejía, David Valle‐García, Félix Recillas Targa · 2011 · IUBMB Life
The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell–Attracting Cytokines
Patrick M. Perrigue, Michael E. Silva, Charles Warden, Nathan L. Feng, Michael A. Reid, Daniel J. Mota, Lauren P. Joseph, Yangzi Isabel Tian, Carlotta A. Glackin, Margarita Gutova et al. · 2015 · Molecular Cancer Research
Programming differentiation potential in mesenchymal stem cells
Philippe Collas · 2010 · Epigenetics
Prostatic preneoplasia and beyond
Anthony Michael Joshua, A. Evans, Theodorus van der Kwast, Maria Zieleńska, Alan Keith Meeker, Arul M. Chinnaiyan, Jeremy Andrew Squire · 2007 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal carcinoma cells by targeting STAT3
Shan Xu, Ning Zhao, LIAN HUI, Min Song, Ziwei Miao, Xuejun Jiang · 2015 · Oncology Reports · Retracted
miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
Nibedita Patel, Koteswara Rao Garikapati, RAJ KUMAR PANDITA, Dharmendra Kumar Singh, Tej K. Pandita, Utpal Bhadra, Manika Pal Bhadra · 2017 · Scientific Reports
Roles of histone <scp>H3K27</scp> trimethylase <scp>E</scp>zh2 in retinal proliferation and differentiation
Iida, Atsumi, Iwagawa, Toshiro, Baba, Yukihiro, Satoh, Shinya, Mochizuki1, Yujin, Nakauchi, Hiromitsu, Furukawa, Takahisa, Koseki, Haruhiko, Murakami, Akira, Watanabe, Sumiko · 2015 · Developmental Neurobiology
Regulation of Senescence in Cancer and Aging
Yahui Kong, Hang Cui, Charusheila Ramkumar, Hong Zhang · 2011 · Journal of Aging Research
DNA Methylation Changes duringIn VitroPropagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?
Angela Bentivegna, Mariarosaria Miloso, Gabriele Riva, Dana Foudah, Valentina Butta, Leda Dalprà, G Tredici · 2013 · Stem Cells International
Genes Involved in Differentiation, Stem Cell Renewal, and Tumorigenesis Are Modulated in Telomerase-Immortalized Human Urothelial Cells
Emma Chapman, Gavin P. Kelly, Margaret A. Knowles · 2008 · Molecular Cancer Research
A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence
Srikanth Talluri, Christian E. Isaac, Mohammad Abd El-Rahman Ahmad, Shauna A. Henley, Sarah M. Francis, Alison L. Martens, Rod Bremner, Frederick A. Dick · 2009 · Molecular and Cellular Biology
Identification of evolutionarily conserved genetic regulators of cellular aging
Gerhard Thomas Laschober, Doris Ruli, Edith Hofer, Christoph Mück, Didac Carmona‐Gutiérrez, Julia Ring, Eveline Hütter, Christoph Ruckenstuhl, Lucia Mičutková, Regina Brunauer et al. · 2010 · Aging Cell
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
Sima Kheradmand Kia, Parham Solaimani Kartalaei, Elnaz Farahbakhshian, Farzin Pourfarzad, Marieke v. Lindern, C. Peter Verrijzer · 2009 · Epigenetics & Chromatin
Epigenetics of Aging
Marta Sierra, Agustín F. Fernández, Mario F. Fraga · 2015 · Current Genomics
MUC1-C activates BMI1 in human cancer cells
Masayuki Hiraki, Takahiro Maeda, Audrey Bouillez, M Alam, Ashujit Tagde, Kunihiko Hinohara, Yozo Suzuki, Tahireh Markert, Masaaki Miyo, K Komura et al. · 2016 · Oncogene
BMI-1 Mediates Estrogen-Deficiency–Induced Bone Loss by Inhibiting Reactive Oxygen Species Accumulation and T Cell Activation
Jinbo Li, Qian Wang, Renlei Yang, Jiaqi Zhang, Xing Li, Xichao Zhou, Dengshun Miao · 2016 · Journal of Bone and Mineral Research
Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions
Idan Cohen, Carmit Bar, Elena Ezhkova · 2020 · BioEssays
Polycomb Group Proteins Are Key Regulators of Keratinocyte Function
Richard L. Eckert, Gautam Adhikary, Ellen A. Rorke, Yap Ching Chew, Sivaprakasam Balasubramanian · 2010 · Journal of Investigative Dermatology
Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma
Kazuaki Teshima, Miho Nara, Atsushi Watanabe, M Ito, Sho Ikeda, Y Hatano, Koichi Oshima, M Seto, K Sawada, H Tagawa · 2013 · Oncogene
Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors
Maria A. Hahn, Arthur X. Li, Xiwei Wu, Richard H. Yang, David A. Drew, Daniel W. Rosenberg, Gerd P. Pfeifer · 2014 · Cancer Research
Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung
Laura A. Galvis, Aliaksei Z. Holik, Kieran M. Short, Julie Pasquet, Aaron T. L. Lun, Marnie E. Blewitt, Ian Smyth, Matthew E. Ritchie, Marie-Liesse Asselin-Labat · 2015 · Development
YY1 restrained cell senescence through repressing the transcription of p16
Xiuli Wang, Yunpeng Feng, Liang Xu, Yu‐Li Chen, Yu Zhang, Dongmei Su, Guoling Ren, Jun Lü, Baiqu Huang · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies
Tadahito Yasuda, Hideo Baba, Takatsugu Ishimoto · 2021 · FEBS Journal
The tumor suppressor role of CTCF
Francesco Paolo Fiorentino, Antonio Giordano · 2011 · Journal of Cellular Physiology
Talking to chromatin: post-translational modulation of polycomb group function
Hanneke E.C. Niessen, Jeroen Demmers, Jan Willem Voncken · 2009 · Epigenetics & Chromatin
MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence
Lettieri-Barbato, Daniele, Aquilano, Katia, Punziano, Carolina, Minopoli, Giuseppina, Faraonio, Raffaella · 2022 · Antioxidants
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
Elena V. Efimova, Oliver K. Appelbe, Natalia Ricco, Steve S.-Y. Lee, Yue Liu, Donald J. Wolfgeher, Tamica N. Collins, Amy C. Flor, Aishwarya Ramamurthy, Sara E. Warrington et al. · 2019 · Molecular Cancer Research
microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts
Manjari Dimri, Jeremy D. Carroll, Joon Cho, Goberdhan P. Dimri · 2013 · Cell Cycle
Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
Pemberton, Helen, Anderton, Emma, Patel, Harshil, Brookes, Sharon, Chandler, Hollie, Palermo, Richard, Stock, Julie, Rodriguez-Niedenführ, Marc, Racek, Tomas, de Breed, Lucas et al. · 2014 · Genome Biology
The Histone Demethylase Jarid1b (Kdm5b) Is a Novel Component of the Rb Pathway and Associates with E2f-Target Genes in MEFs during Senescence
Jeroen H. Nijwening, Ernst-Jan Geutjes, René Bernards, Roderick L. Beijersbergen · 2011 · PLoS ONE
βTrCP regulates BMI1 protein turnover via ubiquitination and degradation
Anagh Anant Sahasrabuddhe, Manjari Dimri, Prashant V. Bommi, Goberdhan P. Dimri · 2011 · Cell Cycle
Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK–JMJD3–p16INK4a signaling axis
T-Y Lin, Y-C Cheng, H-C Yang, W-C Lin, C-C Wang, P-L Lai, Sheau-Yann Shieh · 2011 · Oncogene
Reexpression of hSNF5 in Malignant Rhabdoid Tumor Cell Lines Causes Cell Cycle Arrest through a p21CIP1/WAF1-Dependent Mechanism
Yasumichi Kuwahara, Aubri L. Charboneau, Erik S. Knudsen, Bernard E. Weissman · 2010 · Cancer Research
FOXA1 mediates p16INK4a activation during cellular senescence
Qian Li, Yu Zhang, Jingxuan Fu, Limin Han, Lixiang Xue, Cuicui Lv, Pan Wang, Guodong Li, Tanjun Tong · 2013 · The EMBO Journal
Role of EZH2 histone methyltrasferase in melanoma progression and metastasis
Fade Aziz Mahmoud, Bradley D. Shields, Issam Makhoul, Laura Fulper Hutchins, Sara C. Shalin, Alan J. Tackett · 2016 · Cancer Biology & Therapy
The Antitumor Effect of Metformin Is Mediated by miR-26a in Breast Cancer
Paula Cabello, Begoña Pineda, Eduardo Tormo, Ana M. Lluch, Pîlar Eroles · 2016 · International Journal of Molecular Sciences
Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
Zhijian Duan, June X. Zou, Ping Xun Yang, Yuzhuo Z. Wang, Alexander D. Borowsky, Allen C. Gao, Hong‐Wu Chen · 2012 · The Prostate
Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals
Xudong Wu, Ida Holst Bekker-Jensen, Jesper Frank Christensen, Kasper Dindler Rasmussen, Simone Sidoli, Yan Qi, Yu Kong, Xi Wang, Yajuan Cui, Zhijian Xiao et al. · 2015 · Cell Research
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
Stephanie L. Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu et al. · 2020 · Cancer Cell
The Immediate Early Gene Product EGR1 and Polycomb Group Proteins Interact in Epigenetic Programming during Chondrogenesis
Frank Spaapen, Guus van den Akker, Marjolein M. J. Caron, Peggy Prickaerts, Celine Rofel, Vivian E.H. Dahlmans, D.A. Surtel, Yvette W.J. Paulis, Finja Schweizer, Tim J. M. Welting et al. · 2013 · PLoS ONE
Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors
Tatiana Subkhankulova, Xuemin Zhang, Carly Leung, Silvia Marino · 2010 · Molecular and Cellular Neuroscience
Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum
Xuesong Feng, Aster H. Juan, Hongjun A. Wang, Kyung Dae Ko, Hossein Zare, Vittorio Sartorelli · 2016 · Development
Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration
Miriam Richardson, Des Raymond Richardson · 2023 · Molecular Pharmacology
Oxidative stress and cell senescence as drivers of ageing: Chicken and egg
Thomas von Zglinicki · 2024 · Ageing Research Reviews
Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells
Shunsuke Nakamura, Motohiko Oshima, Jin Yuan, Atsunori Saraya, Satoru Miyagi, Takaaki Konuma, Satoshi Yamazaki, Mitsujiro Osawa, Hiromitsu Nakauchi, Haruhiko Koseki et al. · 2012 · PLoS ONE
NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
Derya Kabacaoğlu, Dietrich Alexander Ruess, Jiaoyu Ai, Hana Algül · 2019 · Cancers
Epigenomic profiling of cancer cells
Gaetano Gargiulo, Saverio Minucci · 2008 · The International Journal of Biochemistry & Cell Biology
Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence*
A. Tsujii, Y. Miyamoto, Tetsuji Moriyama, Y. Tsuchiya, C. Obuse, K. Mizuguchi, Masahiro Oka, Y. Yoneda · 2015 · Journal of Biological Chemistry
Tumor suppressor gene p16/INK4A/CDKN2A‐dependent regulation into and out of the cell cycle in a spontaneous canine model of breast cancer
Payal Agarwal, Maninder Sandey, Patricia DeInnocentes, R. Curtis Bird · 2012 · Journal of Cellular Biochemistry
Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?
Maïka Jangal, Benjamin Lebeau, Michael Witcher · 2019 · Expert Opinion on Therapeutic Targets
Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation
Jessy Etienne, Chao Liu, Colin M. Skinner, Michael J. Conboy, I. Conboy · 2020 · Skeletal Muscle