FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
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- Primary endothelial cell–specific regulation of hypoxia‐inducible factor (HIF)‐1 and HIF‐2 and their target gene expression profiles during hypoxiaBartoszewski, Rafal, Moszyńska, Adrianna, Serocki, Marcin, Cabaj, Aleksandra, Polten, Andreas, Ochocka, Renata, Dell'Italia, Louis, Bartoszewska, Sylwia, Króliczewski, Jarosław, Dąbrowski, Michał et al. · 2019 · The FASEB Journal
- Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitorsChristina Warnecke, Wanja Griethe, Alexander Weidemann, Jan Steffen Jürgensen, Carsten Willam, Sebastian Bachmann, Yuri Ivashchenko, Ingrid Wagner, Ulrich A. Frei, Michael Wiesener et al. · 2003 · The FASEB Journal
- Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and AngiogenesisLothar Rössig, Huige Li, Beate Fißlthaler, Carmen Urbich, Ingrid Fleming, Ulrich Förstermann, Andreas Michael Zeiher, Stefanie Dimmeler · 2002 · Circulation Research
- Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional ActivityHiroyuki Kato, Shiori Tamamizu‐Kato, Futoshi Shibasaki · 2004 · Journal of Biological Chemistry
- Cancer Drug Discovery and DevelopmentJeffrey S. Humphrey, Karen Price, Elora Gupta, Andrew R. W. Baxter, John Bird, Daryl S. Sonnichsen, Joseph G. Naglich · 2003 · Humana Press eBooks
- The Hypoxia-Inducible Factor 2 α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In VivoYan, Qin, Bartz, Steven, Mao, Mao, Li, Lianjie, Kaelin, William G. · 2007 · Molecular and Cellular Biology
- Molecular responses to hypoxia in tumor cells.Manfred Kunz, Saleh Mohamed Ibrahim · 2003 · Molecular Cancer
- Hypoxia and Hypoxia Signaling in Tissue Repair and FibrosisZerina Lokmic‐Tomkins, James N. Musyoka, Tim D. Hewitson, Ian Andrew Darby · 2012 · International review of cytology
- Overproduction of Vascular Endothelial Growth Factor Related to von Hippel-Lindau Tumor Suppressor Gene Mutations and Hypoxia-Inducible Factor-1α Expression in Renal Cell Carcinomas.X.I. NA, Guan Wu, Charlotte Ryan, Susan R. Schoen, P. Anthony diSant’Agnese, Edward M. Messing · 2003 · The Journal of Urology
- Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensingZimmer, Michael, Ebert, Benjamin L., Neil, Christopher, Brenner, Keith, Papaioannou, Ioannis, Melas, Antonia, Tolliday, Nicola, Lamb, Justin, Pantopoulos, Kostas, Golub, Todd et al. · 2008 · Molecular Cell
- Hypoxia in tissue repair and fibrosisIan Andrew Darby, Tim D. Hewitson · 2016 · Cell and Tissue Research
- Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factorsSamanta, Debangshu, Semenza, Gregg L. · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Transcriptional Activation of the Human Leptin Gene in Response to HypoxiaGrazia Ambrosini, Anjali K. Nath, M. Rocı́o Sierra-Honigmann, Jaime R. Flores-Riveros · 2002 · Journal of Biological Chemistry
- Targeted genes and interacting proteins of hypoxia inducible factor-1.Wei Liu, Shao Ming Shen, Xu Zhao, Guo Qiang Chen · 2012 · Europe PMC (PubMed Central)
- Redox regulation of the hypoxia-inducible factorPouysségur, Jacques, Mechta-Grigoriou, Fatima · 2006 · Biological Chemistry
- Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase InhibitorsYa‐Min Tian, Kar Kheng Yeoh, Myung Kyu Lee, Tuula Eriksson, Benedikt Mathias Kessler, Holger Kramer, Mariola J. Edelmann, Carsten Willam, Christopher William Pugh, Christopher John Schofield et al. · 2011 · Journal of Biological Chemistry
- Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia‐inducible factor‐1αEun‐Joung Moon, Chul‐Ho Jeong, Joo‐Won Jeong, Kwang Rok Kim, Dae‐Yeul Yu, Seishi Murakami, Chul Woo Kim, Kyu‐Won Kim · 2003 · The FASEB Journal
- HIFs and tumors—causes and consequencesGisele Höpfl, Omolara O. Ogunshola, Max Gassmann · 2004 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancersHakan Cangül · 2004 · BMC Genetics
- The regulation of trophoblast differentiation by oxygen in the first trimester of pregnancyJoanna L. James, PETER R. STONE, Larry Chamley · 2005 · Human Reproduction Update
- Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivoJonas Sjölund, Martin Johansson, Sugata Manna, Carl Norin, Alexander Pietras, Siv Beckman, Elise Nilsson, Börje Ljungberg, Håkan Axelson · 2008 · Journal of Clinical Investigation
- Hypoxia-induced epithelial to mesenchymal transition in cancerRobert Hapke, Scott Mattox Haake · 2020 · Cancer Letters
- Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implicationsLiuqi Yang, Caiyu Lin, Li Wang, Huijie Guo, Xiujie Wang · 2012 · Experimental Cell Research
- The HIF pathway and erythrocytosisLee, Frank S., Percy, Melanie J. · 2011 · Annual Review of Pathology Mechanisms of Disease
- From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and diseaseCaprara, Christian, Grimm, Christian · 2012 · Progress in Retinal and Eye Research
- Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and TransactivityKietzmann, Thomas, Mennerich, Daniela, Dimova, Elitsa Y. · 2016 · Frontiers in Cell and Developmental Biology
- The VHL tumor suppressor: master regulator of HIFHaase, Volker · 2009 · Current Pharmaceutical Design
- Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1α through Activation of Mitogen-activated Protein Kinase PathwayYoung‐Gun Yoo, Seung Hyun Oh, Eun Sook Park, Hyeseong Cho, Naery Lee, Hyunsung Park, Dae Kyong Kim, Dae‐Yeul Yu, Je Kyung Seong, Mi‐Ock Lee · 2003 · Journal of Biological Chemistry
- The von Hippel–Lindau tumor suppressor protein: new insights into oxygen sensing and cancerWilliam Kim, William G. Kaelin · 2003 · Current Opinion in Genetics & Development
- Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive elementŠtefan Kaluz, Milota Kaluzová, Eric J. Stanbridge · 2008 · Clinica Chimica Acta
- HIF hydroxylation and cellular oxygen sensingEric Metzen, Peter John Ratcliffe · 2004 · Biological Chemistry
- HIF in Kidney Disease and DevelopmentLakshman Gunaratnam, Joseph Vincent Bonventre · 2008 · Journal of the American Society of Nephrology
- Molecular targeting of hypoxia in radiotherapySergio Rey, Luana Schito, Marianne Koritzinsky, Bradly G. Wouters · 2016 · Advanced Drug Delivery Reviews
- Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?A. Kuschel, Perikles D. Simon, Suzan Tug · 2011 · Journal of Cellular Physiology
- Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2αSang-ki Park, Agnes M. Dadak, Volker H. Haase, Lucrezia Fontana, Amato J. Giaccia, Randall S. Johnson · 2003 · Molecular and Cellular Biology
- Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placentaMaltepe, Emin, Krampitz, Geoffrey W., Okazaki, Kelly M., Red-Horse, Kristy, Mak, Winifred, Simon, M. Celeste, Fisher, Susan J. · 2005 · Development
- Hypoxia‐mediated biological controlJessica M. Cassavaugh, Karen M. Lounsbury · 2010 · Journal of Cellular Biochemistry
- Temperature regulates hypoxia-inducible factor-1 (HIF-1) in a poikilothermic vertebrate, crucian carp (Carassius carassius)Eeva Rissanen, Hanna K. Tranberg, Jørund Sollid, Göran Nilsson, Mikko Nikinmaa · 2006 · Journal of Experimental Biology
- HIF Hydroxylase Pathways in Cardiovascular Physiology and MedicineTammie Bishop, Peter John Ratcliffe · 2015 · Circulation Research
- Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistanceM Kilic, Hubert Kasperczyk, Simone Fulda, Klaus‐Michael Debatin · 2006 · Oncogene
- Hypoxia-induced Angiogenesis during CarcinogenesisGyu-Sil Choe, Mun-Gyeong Bae, Ju-Won Jeong, Hyo-Eun Mun, Gyu-Won Kim · 2003 · BMB Reports
- Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.Hyungsoo Kim, Ji‐Eun Lee, Eun‐Jung Cho, Jun O. Liu, Hong‐Duk Youn · 2003 · PubMed
- How Can We Overcome Tumor Hypoxia in Radiation Therapy?Hiroshi Harada · 2011 · Journal of Radiation Research
- Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1Dong Hoon Shin, Yang‐Sook Chun, Dong Soon Lee, Eric L. Huang, Jong‐Wan Park · 2008 · Blood
- O2 Activation by Non-Heme Iron EnzymesEdward I. Solomon, Serra Goudarzi, Kyle D. Sutherlin · 2016 · Biochemistry
- A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivoMinamishima, Yoji Andrew, Moslehi, Javid, Padera, Robert F., Bronson, Roderick T., Liao, Ronglih, Kaelin, William G. · 2009 · Molecular and Cellular Biology
- Epigenetics: The epicenter of the hypoxic responseJenny A. Watson, Chris J Watson, Amanda H McCann, John Andrew Baugh · 2010 · Epigenetics
- HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolismVolker H. Haase · 2017 · Hemodialysis International
- The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)Abdullah Ozer, Leeju C. Wu, Richard K. Bruick · 2005 · Proceedings of the National Academy of Sciences
- A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1αLi, Shan Hua, Shin, Dong Hoon, Chun, Yang-Sook, Lee, Myung Kyu, Kim, Myung-Suk, Park, Jong-Wan · 2008 · Molecular Cancer Therapeutics
- Hypoxia and its implications in rheumatoid arthritisCelia María Quiñonez-Flores, Susana Aideé González‐Chávez, César Pacheco‐Tena · 2016 · Journal of Biomedical Science
- Hypoxia-inducible factors and diabetesGunton, Jenny E. · 2020 · Journal of Clinical Investigation
- Dietary hyperglycemia, glycemic index and metabolic retinal diseasesChung‐Jung Chiu, Allen Taylor · 2010 · Progress in Retinal and Eye Research
- Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetesCarla F. Bento, Paulo Pereira · 2011 · Diabetologia
- The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapyReshef Tal, James H. Segars · 2013 · Human Reproduction Update
- Metabolic consequences of oncogenic IDH mutationsSeth J. Parker, Christian M. Metallo · 2015 · Pharmacology & Therapeutics
- HIF1α Protein Stability Is Increased by Acetylation at Lysine 709Hao Geng, Qiong Liu, Changhui Xue, Larry L. David, Tomasz M. Beer, GEORGE V. THOMAS, Mu‐Shui Dai, David Z. Qian · 2012 · Journal of Biological Chemistry
- Apoptotic Cell Death Under HypoxiaSendoel, Ataman, Hengartner, Michael O. · 2014 · Physiology
- Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2Utta Berchner‐Pfannschmidt, Hatice Yamac, Buena Trinidad, Joachim Fandrey · 2006 · Journal of Biological Chemistry
- Skeletal Muscle Hypoxia-inducible Factor-1 and ExerciseLindholm, Malene E., Rundqvist, Helene · 2016 · Experimental Physiology
- LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent MannerKenichiro Nishi, Tomoyuki Oda, Satoshi Takabuchi, Seiko Oda, Kazuhiko Fukuda, Takehiko Adachi, Gregg L. Semenza, Koh Shingu, Kiichi Hirota · 2008 · Antioxidants and Redox Signaling
- Hypoxia inducible factors in hepatocellular carcinomaChu Chen, Tao Lou · 2017 · Oncotarget
- Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!Timo Gaber, René Dziurla, Robert Tripmacher, Gerd Rüdiger Burmester, Frank Buttgereit · 2005 · Annals of the Rheumatic Diseases
- Microenvironment and Radiation TherapyMichio Yoshimura, Satoshi Itasaka, Hiroshi Harada, Masahiro Hiraoka · 2012 · BioMed Research International
- Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target GenesIneke P. Stolze, Ya-Min Tian, Rebecca J. Appelhoff, Helen Turley, Charles C. Wykoff, Jonathan Gleadle, Peter John Ratcliffe · 2004 · Journal of Biological Chemistry
- Hypoxia-inducible factor pathway and diseases of the vascular wallChung Sim Lim, Serafim Kiriakidis, Ann Sandison, Ewa M Paleolog, Alun Huw Davies · 2013 · Journal of Vascular Surgery
- Control of the hypoxic response through regulation of mRNA translationBradly G. Wouters, Twan van den Beucken, Michaël G. Magagnin, Marianne Koritzinsky, Diane R. Fels, Constantinos Koumenis · 2005 · Seminars in Cell and Developmental Biology
- HYPOXIA‐INDUCED ERYTHROPOIETIN PRODUCTION: A PARADIGM FOR OXYGEN‐REGULATED GENE EXPRESSIONChristian Stockmann, Joachim Fandrey · 2006 · Clinical and Experimental Pharmacology and Physiology
- HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer DisordersHamid Reza Rezvani, Nsrein Ali, L. Johan Nissen, Ghida Harfouche, Hubert de Verneuil, Alain Taı̈eb, Frédéric Mazurier · 2011 · Journal of Investigative Dermatology
- HIF-1: master and commander of the hypoxic worldNathalie M. Mazure, M. Christiane Brahimi-Horn, Mélanie Berta, Emmanuel Isaac Benizri, Rebecca L. Bilton, Frédéric Dayan, Amandine Ginouvès, Edurne Berra, Jacques Pouysségur · 2004 · Biochemical Pharmacology
- The VHL tumor suppressor and HIF: insights from genetic studies in miceKapitsinou, P P, Haase, V H · 2008 · Cell Death & Differentiation
- Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanomaKe Hu, Savalan Babapoor-Farrokhran, Murilo Wendeborn Rodrigues, Monika M. Deshpande, Brooks Puchner, Fabiana Kashiwabuchi, Syed Junaid Hassan, Laura Asnaghi, James T. Handa, Shannath L. Merbs et al. · 2016 · Oncotarget
- Hypoxia, HIFs and bone developmentElisa Araldi, Ernestina Schipani · 2010 · Bone
- Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter HistonesJason E. Fish, Matthew S. Yan, Charles Christian Matouk, Rosanne St. Bernard, J. J. David Ho, Anna Gavryushova, Deepak Srivastava, Philip A. Marsden · 2009 · Journal of Biological Chemistry
- Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxiaSylwia Bartoszewska, James F. Collawn · 2020 · Cellular & Molecular Biology Letters
- HIF-1 and hypoxic response: the plot thickensLorenz Poellinger, Randall S. Johnson · 2003 · Current Opinion in Genetics & Development
- Selective Inhibition of Factor Inhibiting Hypoxia-Inducible FactorM.A. McDonough, Luke A. McNeill, Mélanie Tilliet, Cyril A. Papamicaël, Qiu‐Yun Chen, Biswadip Banerji, Kirsty S. Hewitson, Christopher John Schofield · 2005 · Journal of the American Chemical Society
- How oxygen makes its presence felt: Figure 1.William G. Kaelin · 2002 · Genes & Development
- Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)Olli Arjamaa, Mikko Nikinmaa, Antero Salminen, Kai Kaarniranta · 2009 · Ageing Research Reviews
- Nitric oxide, apoptosis and macrophage polarization during tumor progressionAndreas Weigert, Bernhard Brüne · 2008 · Nitric Oxide
- Genetic and hypoxic regulation of angiogenesis in gliomasBalveen Kaur, Chalet Tan, Daniel Jay Brat, Erwin G. Van Meir · 2004 · Journal of Neuro-Oncology
- Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular DiseasesRamya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Ashim K. Mitra · 2013 · Current Drug Targets
- Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation ReprogrammingCustodia García‐Jiménez, Colin R. Goding · 2018 · Cell Metabolism
- The HIF pathway as a therapeutic targetKirsty S. Hewitson, Christopher John Schofield · 2004 · Drug Discovery Today
- The subtle side to hypoxia inducible factor (HIFα) regulationRebecca L. Bilton, Grant W. Booker · 2003 · European Journal of Biochemistry
- Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCsDuohong Zou, Zhiyuan Zhang, Jiacai He, Kai Zhang, Dongxia Ye, Wei Han, Jian Zhou, Yuanyin Wang, Quanli Li, Xin Liu et al. · 2011 · Biomaterials
- Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 DimerizationYe V. Liu, Maimon E. Hubbi, Fan Pan, Karin R. McDonald, Malini Mansharamani, Robert Norman Cole, Jun O. Liu, Gregg L. Semenza · 2007 · Journal of Biological Chemistry
- Adaptive Responses to Hypoxia and/or Hyperoxia in HumansJohannes Burtscher, Robert T. Mallet, Vincent Pialoux, Grégoire Paul Millet, Martin Burtscher · 2022 · Antioxidants and Redox Signaling
- Molecular regulation of the VEGF family – inducers of angiogenesis and lymphangiogenesisBradley McColl, Steven A. Stacker, Marc G. Achen · 2004 · Apmis
- Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBPSang, Nianli, Fang, Jie, Srinivas, Vickram, Leshchinsky, Irene, Caro, Jaime · 2002 · Molecular and Cellular Biology
- Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent MechanismPhilip M. Elks, Sabrina Brizee, Michiel van der Vaart, Sarah R. Walmsley, Fredericus J. van Eeden, Stephen A. Renshaw, Annemarie H. Meijer · 2013 · PLoS Pathogens
- Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and PerspectivesKai Sun, Xin Li, Philipp E. Scherer · 2023 · Comprehensive physiology
- Hypoxia-inducible factor (HIF) in human tumorigenesis.Nicola J. Mabjeesh, Sharon Amir · 2007 · PubMed
- Biological Functions and Regulatory Mechanisms of Hypoxia-Inducible Factor-1α in Ischemic StrokeQianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, Junlei Chang, Zhen‐Ni Guo, Yi R Yang · 2021 · Frontiers in Immunology
- Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic StressMeriem Hasmim, Yosra Messai, Linda Ziani, Jérôme Thiery, Jean-Henri Bouhris, Muhammad Zaeem Noman, Salem Chouaı̈b · 2015 · Frontiers in Immunology
- Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular SignalingLaurence M. Gagné, Karine Boulay, Ivan Topisirović, Marc‐Étienne Huot, Frédérick A. Mallette · 2017 · Trends in Cell Biology
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- Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancerJiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu · 2025 · Cellular & Molecular Biology Letters