Hypoxia-inducible factors and diabetes

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

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Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

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Hypoxia-inducible factors in physiology and medicine

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Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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A conserved family of prolyl-4-hydroxylases that modify HIF

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Mitochondrial dysfunction and type 2 diabetes

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Oxygen sensing by HIF hydroxylases

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Oxygen-induced retinopathy in the mouse.

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HIF‐1α is required for solid tumor formation and embryonic vascularization

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Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

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The GLUT4 Glucose Transporter

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

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Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

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Chronic Hypoxia and Tubulointerstitial Injury

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Five stages of evolving beta-cell dysfunction during progression to diabetes

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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

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Fibrosis and adipose tissue dysfunction.

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Biology of HIF-1α

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Signaling pathways in insulin action: molecular targets of insulin resistance

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Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

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Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

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Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

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Intravitreal Bevacizumab (Avastin) in the Treatment of Proliferative Diabetic Retinopathy

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Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

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Obesity, insulin resistance and diabetes — a worldwide epidemic

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Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α

Yuan, Y., Hilliard, G., Ferguson, T., & Millhorn, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300463200 · Cited by 638 · see citing works

The changing face of diabetes complications

Gregg, E. W., Sattar, N. A., & Ali, M. K. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30010-9 · Cited by 622 · see citing works

The mammalian basic helix–loop–helix/PAS family of transcriptional regulators

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Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

Rey, S., & Semenza, G. L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq045 · Cited by 536 · see citing works

Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805230105 · Cited by 533 · see citing works

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., et al. (2002) · Nature Genetics · doi:10.1038/ng1019 · Cited by 510 · see citing works

Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes

Gunton, J. E., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W. J., Tseng, Y., Roberson, R. S., Ricordi, C., O’Connell, P. J., Gonzalez, F. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.027 · Cited by 489 · see citing works

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Aragonés, J., Schneider, M. A., Geyte, K. V., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.62 · Cited by 472 · see citing works

Pancreatic involvement in von Hippel–Lindau disease

Hammel, P. R., Vilgrain, V., Terris, B., Penfornis, A., Sauvanet, A., Corréas, J.-M., Chauveau, D., Balian, A., Beigelman‐Aubry, C., O’Toole, D., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.18143 · Cited by 425 · see citing works

Insulin resistance and pancreatic cell failure

Kasuga, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29189 · Cited by 412 · see citing works

The role of hypoxia-inducible factors in metabolic diseases

Gonzalez, F. J., Xie, C., & Jiang, C. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0096-z · Cited by 406 · see citing works

Mortality attributable to diabetes: Estimates for the year 2010

Roglić, G., & Unwin, N. C. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.006 · Cited by 400 · see citing works

Somatic<i>HIF2A</i>Gain-of-Function Mutations in Paraganglioma with Polycythemia

Zhuang, Z., Yang, C., Lorenzo, F., Merino, M., Fojo, T., Kebebew, E., Popovic, V., Stratakis, C. A., Prchal, J. T., & Pacak, K. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205119 · Cited by 397 · see citing works

Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function

Catrina, S., Okamoto, K., Pereira, T., Brismar, K., & Poellinger, L. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3226 · Cited by 385 · see citing works

The Effect of Glucose Variability on the Risk of Microvascular Complications in Type 1 Diabetes

Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2006) · Diabetes Care · doi:10.2337/dc06-0293 · Cited by 376 · see citing works

Thirty sweet years of GLUT4

Klip, A., McGraw, T. E., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008351 · Cited by 344 · see citing works

Primary Intravitreal Bevacizumab (Avastin) for Diabetic Macular Edema

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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

Percy, M. J., Zhao, Q., Flores, A., Harrison, C., Lappin, T. R. J., Maxwell, P. H., McMullin, M. F., & Lee, F. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508423103 · Cited by 330 · see citing works

Resurgence of Diabetes-Related Nontraumatic Lower-Extremity Amputation in the Young and Middle-Aged Adult U.S. Population

Geiss, L. S., Li, Y., HORA, I. A., Albright, A. L., Rolka, D. B., & Gregg, E. W. (2018) · Diabetes Care · doi:10.2337/dc18-1380 · Cited by 320 · see citing works

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

Takeda, Y., Costa, S., Delamarre, E., Roncal, C., de Oliveira, R. L., Squadrito, M. L., Finisguerra, V., Deschoemaeker, S., Bruyére, F., Wenes, M., et al. (2011) · Nature · doi:10.1038/nature10507 · Cited by 287 · see citing works

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

Hill, P., Shukla, D., Tran, M. G. B., Aragonés, J., Cook, H. T., Carmeliet, P., & Maxwell, P. H. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006090998 · Cited by 280 · see citing works

Hypoxic induction of Ctgf is directly mediated by Hif-1

Higgins, D. F., Biju, M. P., Akai, Y., Wutz, A., Johnson, R. S., & Haase, V. H. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00245.2004 · Cited by 279 · see citing works

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice

Jiang, C., Qu, A., Matsubara, T., Chanturiya, T., Jou, W., Gavrilova, O., Shah, Y. M., & Gonzalez, F. J. (2011) · Diabetes · doi:10.2337/db11-0174 · Cited by 268 · see citing works

Autoimmune mechanisms in type 1 diabetes

Knip, M., & Siljander, H. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.04.008 · Cited by 266 · see citing works

Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis

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The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses

Bracken, C. P., Whitelaw, M. L., & Peet, D. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2370-y · Cited by 255 · see citing works

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

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Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules

Li, J., Liu, H., Takagi, S., Nitta, K., Kitada, M., Srivastava, S. P., Takagaki, Y., Kanasaki, K., & Koya, D. (2020) · JCI Insight · doi:10.1172/jci.insight.129034 · Cited by 244 · see citing works

Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia

Yuan, G., Nanduri, J., Bhasker, C. R., Semenza, G. L., & Prabhakar, N. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407706200 · Cited by 242 · see citing works

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction

Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00951-12 · Cited by 231 · see citing works

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

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Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

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Insulin resistance is a risk factor for progression to Type 1 diabetes

Fourlanos, S., Narendran, P., Byrnes, G. B., Colman, P. G., & Harrison, L. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1507-3 · Cited by 228 · see citing works

Diabetes Mellitus: Incidence, Prevalence, Survivorship, and Causes of Death in Rochester, Minnesota, 1945–1970

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Renal diffusion and BOLD MRI in experimental diabetic nephropathy

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Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway

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Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF

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Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance

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Cardiac myocyte‐specific HIF‐1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

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The effect of altitude hypoxia on glucose homeostasis in men

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HIF-1: the knowns and unknowns of hypoxia sensing.

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Apoptosis in hypoxic human pancreatic islets correlates with HIF‐1α expression

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Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy

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Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury

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Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1

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Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes

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Skeletal Muscle Hypoxia-inducible Factor-1 and Exercise

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Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

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The subtle side to hypoxia inducible factor (HIFα) regulation

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Hyperbaric oxygen therapy activates hypoxia‐inducible factor 1 ( HIF ‐1), which contributes to improved wound healing in diabetic mice

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Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model

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Regulation of Gene Expression by HIF‐1

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Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes

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HIF-1-driven skeletal muscle adaptations to chronic hypoxia: molecular insights into muscle physiology

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Accumulated ROS Activates HIF-1α-Induced Glycolysis and Exerts a Protective Effect on Sensory Hair Cells Against Noise-Induced Damage

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Associations Among Microvascular Dysfunction, Fatty Acid Metabolism, and Diabetes

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Breaking the Vicious Cycle: Nanozyme‐Driven Multimodal Therapeutics for Diabetic Wound Regeneration

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Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules

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Novel Therapeutics for Diabetic Retinopathy and Diabetic Macular Edema: A Pathophysiologic Perspective

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Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration

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Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia

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Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: A narrative review

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The Application of Functional Magnetic Resonance Imaging in Type 2 Diabetes Rats With Contrast-Induced Acute Kidney Injury and the Associated Innate Immune Response

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Elevation of Circulating miR-210 Participates in the Occurrence and Development of Type 2 Diabetes Mellitus and Its Complications

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Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy

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Effects of Vitamin D Supplementation in Diabetic Kidney Disease: A Systematic Review

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siHIF-1α-loaded micellar nanoparticles inhibit M1 macrophage activation to ameliorate chronic rhinosinusitis

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Hypoxia-Inducible Factors and Burn-Associated Acute Kidney Injury—A New Paradigm?

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Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat

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Downregulated calmodulin expression contributes to endothelial cell impairment in diabetes

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Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency

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Effective prediction of potential ferroptosis critical genes in clinical colorectal cancer

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Improving cellular fitness of human stem cell-derived islets under hypoxia

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TGF‐beta pathway inhibition as the therapeutic acceleration of diabetic bone regeneration

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The signaling pathway of hypoxia inducible factor in regulating gut homeostasis

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Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis

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In-Situ Fabricated Living Nanofiber Scaffolds with Stem Cell-Chlorella pyrenoidosa for Synergy Enhance Diabetic Wound Healing

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Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis

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DPP-4i versus SGLT2i as modulators of PHD3/HIF-2α pathway in the diabetic kidney

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α-Glucosidase Inhibition-Guided Network Pharmacology and Molecular Docking Reveal the Antidiabetic Potential of Cichorium intybus as a Functional Food

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Safety of daprodustat in patients with anemia of chronic kidney disease: A pooled analysis of phase 3 studies in Japan

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Hypoxia-Induced circRNAs in Human Diseases: From Mechanisms to Potential Applications

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Spatiotemporal Regulation of Injectable Heterogeneous Silk Gel Scaffolds for Accelerating Guided Vertebral Repair

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CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer

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Hypoxia Potentiated Lung Cancer Cell Migration and Invasion by up-regulating HIF1α/JAK2/STAT3 Axis and Activating MMP13 Transcription

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Exploring the Role of Hypoxia and HIF-1α in the Intersection of Type 2 Diabetes Mellitus and Endometrial Cancer

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Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients

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Revealing the improvement of diabetes by Si Wei Jiang Huang Tang San through ERK/HIF1α signaling pathway via network pharmacology

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Hypoxic microenvironment promotes dermal fibroblast migration and proliferation via a BNIP3 ‐autophagy pathway

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Effects of Oxygen Tension for Membrane Lipidome Remodeling of Cockayne Syndrome Cell Models

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Hyperbaric oxygen therapy and chemokine administration - a combination with potential therapeutic value for treating diabetic wounds

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Role of hypoxia inducible factor HIF-1⍺ in heart valves

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Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskPreprint

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Brain endothelial HIF-1α exacerbates diabetes-associated cognitive impairment by accelerating glycolysis-driven lactate production

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Risks of Developing Diabetes and Hyperglycemic Crisis Following Carbon Monoxide Poisoning: A Study Incorporating Epidemiologic Analysis and Animal Experiment

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iHypoxia: An Integrative Database of Protein Expression Dynamics in Response to Hypoxia in Animals

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