SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Translating the Histone Code

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The language of covalent histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

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Regulation of Transcription by a Protein Methyltransferase

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

Tamaru, H., & Selker, E. U. (2001) · Nature · doi:10.1038/35104508 · Cited by 1,054

Epigenetics of Reproduction

McCarthy, M. M., & Rissman, E. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00052-1 · Cited by 9

Epigenetic Regulation of the Non-Coding Genome: Opportunities for Immuno-Oncology

Barrero, M. J. (2020) · Epigenomes · doi:10.3390/epigenomes4030022 · Cited by 10

Epigenetic Mechanisms of Mental Retardation

Schaefer, A., Tarakhovsky, A., & Greengard, P. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_7 · Cited by 9

ZFP57: KAPturing DNA Methylation at Imprinted Loci

Ideraabdullah, F., & Bartolomei, M. S. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.008 · Cited by 9

Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells

Wang, G. Z., & Goff, S. P. (2016) · Journal of Virology · doi:10.1128/jvi.02075-16 · Cited by 9

Heterochromatin and the molecular mechanisms of ‘parent-of-origin’ effects in animals

Singh, P. B. (2016) · Journal of Biosciences · doi:10.1007/s12038-016-9650-9 · Cited by 9

SETDB1 plays an essential role in maintenance of gonocyte survival in pigs

Liu, T., Zhang, P., Li, T., Chen, X., Zhu, Z., Lyu, Y., Li, X., Tian, X., & Zeng, W. (2017) · Reproduction · doi:10.1530/rep-17-0107 · Cited by 9

TRIM28 down-regulation on methylation imprints in bovine preimplantation embryos

Ma, X., Zhang, S., Zhang, M., Zhu, Y., Ma, P., Yang, S., Su, L., Li, Z., Lv, W., & Luan, W. (2018) · Zygote · doi:10.1017/s0967199418000424 · Cited by 9

Histone modifications

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Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity

Xie, Q., Du, Y., Ghosh, S., Rajendran, S., Cohen-Gadol, A. A., Baizabal, J.-M., Nephew, K. P., Han, L., & Shen, J. (2025) · NPJ Precision Oncology · doi:10.1038/s41698-025-00829-5 · Cited by 10

Unraveling the role of ZNF506 as a human PBS-pro-targeting protein for ERVP repression

Wu, Q., Fang, L., Wang, Y., & Yang, P. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad731 · Cited by 8

Targeting transposable elements in cancer: developments and opportunities

Wang, Z.-Y., Ge, L., Ouyang, Y., Jin, X., & Jiang, Y. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189143 · Cited by 11

SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain

Chandrasekaran, T., Choudalakis, M., Bröhm, A., Weirich, S., Kouroukli, A. G., Ammerpohl, O., Rathert, P., Bashtrykov, P., & Jeltsch, A. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1053 · Cited by 8

Mechanisms of Inheritance of Chromatin States: From Yeast to Human

Madhani, H. D. (2024) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-070524-091904 · Cited by 8

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Leach, D. A., Chatterjee, N., Spahr, K., de Almeida, G. S., Varela‐Carver, A., Shah, T. T., Winkler, M. H., Ahmed, H. U., & Bevan, C. L. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70065 · Cited by 8

Expressions of Type I and III Interferons, Endogenous Retroviruses, TRIM28, and SETDB1 in Children with Respiratory Syncytial Virus Bronchiolitis

Tovo, P., Garazzino, S., Savino, F., Daprà, V., Pruccoli, G., Dini, M., Filisetti, G., Funiciello, E., Galliano, I., & Bergallo, M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45020079 · Cited by 9

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells

Chang, Y.-J., Lin, S., Kang, Z., Shen, B.-J., Tsai, W.-H., Chen, W., Lu, H.-P., Lin, S., Lin, S.-Y., Chou, S.-J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129830 · Cited by 7

Children with Chronic Immune Thrombocytopenia Exhibit High Expression of Human Endogenous Retroviruses TRIM28 and SETDB1

Tovo, P., Galliano, I., Parodi, E., Calvi, C., Gambarino, S., Licciardi, F., Dini, M., Montanari, P., Branca, M., Ramenghi, U., et al. (2023) · Genes · doi:10.3390/genes14081569 · Cited by 8

SETDB1: Progress and prospects in cancer treatment potential and inhibitor research

Ma, T., Xu, F., Hou, Y., Shu, Y., Zhao, Z., Zhang, Y., Bai, L., Lu, F., & Zhong, L. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107219 · Cited by 7

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

Panzeri, I., Fagnocchi, L., Apostle, S., Tompkins, M., Wolfrum, E., Madaj, Z., Hostetter, G. H., Liu, Y., Schaefer, K., Yang, C.-H., et al. (2025) · Nature Cancer · doi:10.1038/s43018-024-00900-3 · Cited by 8

Evidence that miR-152-3p is a positive regulator of SETDB1-mediated H3K9 histone methylation and serves as a toggle between histone and DNA methylation

Singh, S., Bahal, R., & Rasmussen, T. P. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112216 · Cited by 8

SetDB1 and Su(var)3-9 play non-overlapping roles in somatic cell chromosomes of Drosophila melanogaster

Kalashnikova, D. A., Maksimov, D. A., Romanov, S. E., Laktionov, P. P., & Koryakov, D. E. (2020) · Journal of Cell Science · doi:10.1242/jcs.253096 · Cited by 8

The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues

Shah, P. A., Boutros‐Suleiman, S., Emanuelli, A., Paolini, B., Levy‐Cohen, G., & Blank, M. (2022) · Cancers · doi:10.3390/cancers14071607 · Cited by 9

Significance of Hypermethylation of Tumor-Suppressor Genes PTGER4 and ZNF43 at CpG Sites in the Prognosis of Colorectal Cancer

Chen, C.-Y., Wu, J.-J., Lin, Y.-J., Hsu, C., Hu, J., Chang, P.-K., Sun, C., Yang, T., Su, J.-Q., & Chou, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810225 · Cited by 9

SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

Godneeva, B. K., Ninova, M., Tóth, K. F., & Aravin, A. A. (2023) · eLife · doi:10.7554/elife.89493 · Cited by 7

SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes

Kang, Y.-K., Eom, J., Min, B., & Park, J. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09703-2 · Cited by 7

The KRAB domain zinc finger protein, Zfp157 , is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin

Oliver, C. H., Nichols, J., & Watson, C. J. (2013) · genesis · doi:10.1002/dvg.22367 · Cited by 8

A Pair of Mouse KRAB Zinc Finger Proteins Modulates Multiple Indicators of Female Reproduction1

Krebs, C. J., & Robins, D. M. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.080846 · Cited by 8

KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

Kauzlaric, A., Jang, S. M., Morchikh, M., Cassano, M., Planet, E., Benkirane, M., & Trono, D. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0334 · Cited by 8

The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors

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Transcriptional repression in ES cells

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SUMO wrestling with Ras

Zhang, H., & Luo, J. (2016) · Small GTPases · doi:10.1080/21541248.2016.1161698 · Cited by 8

Synchronized genetic activities in Alzheimer’s brains revealed by heterogeneity-capturing network analysisPreprint

Climer, S., Templeton, A. R., Garvin, M. R., Jacobson, D., Lane, M. J., Hulver, S., Scheid, B. H., Chen, Z., Cruchaga, C., & Zhang, W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.28.923730 · Cited by 8

ChAHP2 and ChAHP control diverse retrotransposons by complementary activitiesPreprint

Ahel, J., Pandey, A., Schwaiger, M., Mohn, F., Basters, A., Kempf, G., Andriollo, A., Kaaij, L. J. T., Heß, D., & Bühler, M. (2024) · Genes & Development · doi:10.1101/gad.351769.124 · Cited by 9

Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features

Yang, S., Jayakumaran, G., Benhamida, J. K., Febres‐Aldana, C. A., Fanaroff, R. E., Chang, J. C., Gedvilaite, E., Villafania, L. B., Sauter, J. L., Offin, M. D., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0085 · Cited by 7

Regulation of CAR transgene expression to design semiautonomous CAR-T

Głowacki, P., Tręda, C., & Rieske, P. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200833 · Cited by 9

KAP1 negatively regulates RNA polymerase II elongation kinetics to activate signal-induced transcription

Hyder, U., Challa, A., Thornton, M. A., Nandu, T. S., Kraus, W. L., & D’Orso, I. (2024) · Nature Communications · doi:10.1038/s41467-024-49905-7 · Cited by 8

Expression of LINE-1 elements is required for preimplantation development and totipotency

Ma, R., Xiao, N., & Liu, N. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101555 · Cited by 7

Co-option of an endogenous retrovirus (LTR7-HERVH) in early human embryogenesis: becoming useful and going unnoticed

Izsvák, Z., Ma, J., Singh, M., & Hurst, L. D. (2025) · Mobile DNA · doi:10.1186/s13100-025-00361-0 · Cited by 11

CRISPR tools for T cells: targeting the genome, epigenome, and transcriptome

Wachsmann, T. L. A., & Qi, L. S. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.08.001 · Cited by 8

Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells

Srinivasan, S. P., Nemade, H., Cherianidou, A., Peng, L., Cruz-Molina, S., Rada-Iglesias, Á., & Sachinidis, A. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01237-5 · Cited by 7

Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

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ZNF219, a novel transcriptional repressor, inhibits transcription of the prototype foamy virus by interacting with the viral LTR promoter

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Ribonucleoprotein Granules: Between Stress and Transposable Elements

Moon, S., & Namkoong, S. (2023) · Biomolecules · doi:10.3390/biom13071027 · Cited by 8

SETDB1 tumour suppressor roles in near-haploid mesothelioma involve TP53

Xu, M., Tu, Y., Bi, W., Lundberg, M. Z., Klooster, I., Fletcher, J. A., & Ou, W. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02330-x · Cited by 7

Transcriptional determinants of lipid mobilization in human adipocytes

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Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation

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Quantifying In Vivo, Site-Specific Changes in Protein Methylation with SILAC

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SETDB1 as a cancer target: challenges and perspectives in drug design

Hassanie, H., Penteado, A. B., de Almeida, L. C., Calil, R. L., Emery, F. D. S., Costa-Lotufo, L. V., & Trossini, G. H. G. (2024) · RSC Medicinal Chemistry · doi:10.1039/d3md00366c · Cited by 7

Nuclear domain 10-associated proteins recognize and segregate intranuclear DNA/protein complexes to negate gene expression

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Roles of RNAi in Chromatin Regulation and Epigenetic Inheritance

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Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.

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Targeted detection and quantitation of histone modifications from 1,000 cells

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Kap1 Regulates the Stability of Lin28A in Embryonic Stem Cells

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Cancer and Epigenesis: A Developmental Perspective

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Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells

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Epigenetic Control of Germline Development

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LINEing germ and embryonic stem cells’ silencing of retrotransposonsPreprint

Ishiuchi, T., & Torres‐Padilla, M. (2014) · Genes & Development · doi:10.1101/gad.246462.114 · Cited by 7

Dysregulation of the epigenetic regulator SETDB1 in liver carcinogenesis—more than one way to skin a cat

Longerich, T. (2016) · Chinese Clinical Oncology · doi:10.21037/cco.2016.03.18 · Cited by 7

Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and TranscriptionPreprint

Feng, Y., Wang, Y., Wang, X., He, X., Chen, Y., Naseri, A., Pederson, T., Zheng, J., Zhang, S., Xiao, X., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.15.204719 · Cited by 7

Histone H3 lysine methyltransferase activities control compartmentalization of human centromeresPreprint

Sidhwani, P., Schwartz, J. P., Fryer, K. A., & Straight, A. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.01.662447 · Cited by 7

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers

Kazerani, M., Cernilogar, F. M., Pasquarella, A., Hinterberger, M., Nuber, A., Klein, L., & Schotta, G. (2024) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2409656121 · Cited by 6

Combination Therapy Approaches to Enhance the Efficacy of ERV-Targeting Vaccines in Cancer

Gracia-Hernandez, M., Maldonado, M. D. M., Schlom, J., & Hamilton, D. H. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-1192 · Cited by 6

Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice

Horii, T., Morita, S., Hino, S., Hino, Y., Fukushima, H. S., Kobayashi, R., Kimura, M., Nakao, M., Mizukami, Y., Inoue, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67488-9 · Cited by 7

Transposable element DNA and RNA: Drivers of gene expression, evolution, and disease

Ho, J., Douse, C. H., & Marazzi, I. (2026) · Cell · doi:10.1016/j.cell.2026.05.003 · Cited by 8

SETDB1 regulates microtubule dynamics

Hernandez‐Vicens, R., Singh, J., Pernicone, N., Listovsky, T., & Gerlitz, G. (2022) · Cell Proliferation · doi:10.1111/cpr.13348 · Cited by 5

Structural evidence for protein-protein interaction between the non-canonical methyl-CpG-binding domain of SETDB proteins and C11orf46

Mahana, Y., Ariyoshi, M., Nozawa, R., Shibata, S., Nagao, K., Obuse, C., & Shirakawa, M. (2023) · Structure · doi:10.1016/j.str.2023.12.001 · Cited by 6

SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer

Yang, H., Sui, L., Cai, C., Chu, H., & Diao, Y. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01358-8 · Cited by 6

Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Zhang, Y., He, F., Zhang, Y., Dai, Q., Li, Q., Jing, N., Miao, R., & Cheng, B. W. (2022) · Mobile DNA · doi:10.1186/s13100-022-00279-x · Cited by 6

Functional dissection of N-terminal nuclear trafficking signals of SETDB1

Eom, J., Jeon, K., Park, J. S., & Kang, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1069765 · Cited by 6

Confinement Mechanisms for Epigenetic Modifications of Nucleosomes

Nickels, J. F., & Sneppen, K. (2023) · PRX Life · doi:10.1103/prxlife.1.013013 · Cited by 7

Identification and characterization of reproductive KRAB-ZF genes in mice

Jin, S., Choi, H., Kwon, J., Kim, J., Jeong, J., Kim, J.-H., Ham, S., Cho, B.-N., Yoo, Y. J., & Cho, C. (2015) · Gene · doi:10.1016/j.gene.2015.03.059 · Cited by 6

Discovering Succinct Pattern Sets Expressing Co-Occurrence and Mutual Exclusivity

Fischer, J., & Vreeken, J. (2020) · ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD) · doi:10.1145/3394486.3403124 · Cited by 6

Oncorhynchus mykiss OmTRIM25 activates the interferon-1 pathway and positively regulates the antiviral innate immune response to infectious hematopoietic necrosis virus

Zhang, Y., Sun, J., Shi, Y., Liu, X., Zhang, M., Xu, B., Song, J. B., Song, Z., Guan, X., Shi, W., et al. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738435 · Cited by 6

ERG-Mediated Cell Invasion: A Link between Development and Tumorigenesis

Blee, A. M., & Huang, H. (2015) · Medical Epigenetics · doi:10.1159/000440978 · Cited by 7

Generation and characterization of mice with mesenchyme‐specific deletion of the entire ESET histone methyltransferase protein

Yang, L., Gee, A. O., Zielinska‐Kwiatkowska, A., & Chansky, H. A. (2017) · genesis · doi:10.1002/dvg.23088 · Cited by 6

BMAL1-TRIM28 represses transposable elements independently of CLOCK in pluripotent cells

Gallardo, A., Belmonte‐Reche, E., Marti-Marimon, M., Domingo-Reinés, J., Peris, G., López-Onieva, L., Fernández-Rengel, I., Xie, J., Tristán-Ramos, P., Bellora, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63778-4 · Cited by 5

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements

Davis, J., Voicu, D., Chitnavis, U., Jaksina, J., & Imbeault, M. (2026) · Nature Genetics · doi:10.1038/s41588-025-02498-3 · Cited by 7

Histone modification cross-talk: analytical tools and molecular mechanisms

Jiang, J., DuBois-Coyne, S. E., Nam, E., Whedon, S. D., Lee, K., & Cole, P. A. (2026) · Biochemical Journal · doi:10.1042/bcj20250115 · Cited by 5

KAP1 is a new non-genetic vulnerability of malignant pleural mesothelioma (MPM)

Lorenzini, E., Torricelli, F., Zamponi, R., Donati, B., Manicardi, V., Sauta, E., do Valle, Í. F., Reggiani, F., Gugnoni, M., Manzotti, G., et al. (2022) · NAR Cancer · doi:10.1093/narcan/zcac024 · Cited by 6

Unveiling the Role of Histone Methyltransferases in Psoriasis Pathogenesis: Insights from Transcriptomic Analysis

Romhányi, D., Bessenyei, Á., Szabó, K., Kemény, L. V., Gyulai, R., & Groma, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136329 · Cited by 7

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription

Sammons, M. A., Zhu, J., & Berger, S. L. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.031534 · Cited by 5

Dynamics and Function of DNA Methylation During Development

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From parasites to partners: exploring the intricacies of host-transposon dynamics and coevolution

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