SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Translating the Histone Code

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The language of covalent histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

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Regulation of Transcription by a Protein Methyltransferase

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

Tamaru, H., & Selker, E. U. (2001) · Nature · doi:10.1038/35104508 · Cited by 1,054

Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres

Chavez, S. L., McElroy, S. L., Bossert, N. L., Jonge, C. J. D., Vera-Rodríguez, M., Leong, D. E., Behr, B. R., Westphal, L. M., & Pera, R. A. R. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu212 · Cited by 32

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter

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CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression

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DNA double-strand break repair within heterochromatic regions

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Setdb1 Is Required for Myogenic Differentiation of C2C12 Myoblast Cells via Maintenance of MyoD Expression

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Step out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Factors

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Dynamic and selective interactions of the transcriptional corepressor TIF1β with the heterochromatin protein HP1 isotypes during cell differentiation

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Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

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Kinetics and Epigenetics of Retroviral Silencing in Mouse Embryonic Stem Cells Defined by Deletion of the D4Z4 Element

Rival‐Gervier, S., Lo, M., Khattak, S., Pasceri, P., Lorincz, M. C., & Ellis, J. (2013) · Molecular Therapy · doi:10.1038/mt.2013.131 · Cited by 33

BET protein BRDT complexes with HDAC1, PRMT5 and TRIM28 and functions in transcriptional repression during spermatogenesis

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Inhibition of Retroviral Replication by Members of the TRIM Protein Family

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SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Delaney, C. E., Methot, S. P., Kalck, V., Seebacher, J., Heß, D., Gasser, S. M., & Padeken, J. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00712-4 · Cited by 29

Inhibitors of DNA Methylation

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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis

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Dynamics of Setdb1 expression in early mouse development

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Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association

Karczewski, K. J., Snyder, M. P., Altman, R. B., & Tatonetti, N. P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004122 · Cited by 31

H3K9 Trimethylation Precedes DNA Methylation during Sheep Oogenesis

Russo, V., Bernabò, N., Giacinto, O. D., Martelli, A., Mauro, A., Berardinelli, P., Curini, V., Nardinocchi, D., Mattioli, M., & Barboni, B. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412463923 · Cited by 32

The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation

Li, J., Chen, X., Yang, H., Wang, S., Guo, B., Yu, L., Wang, Z., & Fu, J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.08.020 · Cited by 31

Identification of a Novel Krüppel-associated Box Domain Protein, Krim-1, That Interacts with c-Myc and Inhibits Its Oncogenic Activity

Hennemann, H., Vaßen, L., Geisen, C., Eilers, M., & Möröy, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207196200 · Cited by 32

ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clustersPreprint

Haring, N. L., van Bree, E. J., Jordaan, W., Roels, J. R. E., Sotomayor, G. C., Hey, T. M., White, F. T. G., Galland, M., Smidt, M. P., & Jacobs, F. M. J. (2021) · Genome Research · doi:10.1101/gr.265348.120 · Cited by 29

H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeatsPreprint

Gualdrini, F., Polletti, S., Simonatto, M., Prosperini, E., Pileri, F., & Natoli, G. (2022) · Genes & Development · doi:10.1101/gad.349282.121 · Cited by 35

A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells

GINN, L. H., Maltas, J., Baker, M. J., Chaturvedi, A., Wilson, L., Guilbert, R., Amaral, F. M. R., Priest, L. J. C., Mole, H., Blackhall, F. H., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300489120 · Cited by 29

Autophagy Promotes the Repair of Radiation-Induced DNA Damage in Bone Marrow Hematopoietic Cells via Enhanced STAT3 Signaling

Xu, F., Li, X., Yuan, N., Fang, Y., Fang, Y., Cao, Y., Xu, L., Zhang, X., Xu, L., Ge, C., et al. (2017) · Radiation Research · doi:10.1667/rr14640.1 · Cited by 30

The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis

Cheng, E.-C., Hsieh, C.-L., Liu, N., Wang, J., Zhong, M., Chen, T., Li, E., & Lin, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108575 · Cited by 30

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

Maruyama, A., Nishikawa, K., Kawatani, Y., Mimura, J., Hosoya, T., Harada, N., Yamamato, M., & Itoh, K. (2011) · Biochemical Journal · doi:10.1042/bj20101748 · Cited by 30

The Structurally Disordered KRAB Repression Domain Is Incorporated into a Protease Resistant Core upon Binding to KAP-1-RBCC Domain

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SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy

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TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency

Tao, Y., Yen, M., Chitiashvili, T., Nakano, H., Kim, R., Hosohama, L., Tan, Y. C., Nakano, A., Chen, P., & Clark, A. T. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.11.020 · Cited by 28

The Drosophila SET domain encoding gene dEset is essential for proper development

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Purification of Histone Methyltransferases from HeLa Cells

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Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

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Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events

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URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells

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KAP1 is an antiparallel dimer with a functional asymmetry

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Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9

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Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells

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The function of histone methylation and acetylation regulators in GBM pathophysiology

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A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor

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It takes a PHD to SUMO.

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The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice?

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Identifying Novel Enhancer Elements with CRISPR-Based Screens

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Reactivation of retrotransposable elements is associated with environmental stress and ageing

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Growth Inhibition of HeLa Cells Is a Conserved Feature of High-Risk Human Papillomavirus E8^E2C Proteins and Can Also Be Achieved by an Artificial Repressor Protein

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Repair of DNA Double-Strand Breaks in Heterochromatin

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Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome

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How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

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Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways

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Reprogramming cell fate with a genome-scale library of artificial transcription factors

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Do social insects support Haig's kin theory for the evolution of genomic imprinting?

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Histone Methylation Restrains the Expression of Subtype-Specific Genes during Terminal Neuronal Differentiation in Caenorhabditis elegans

Zheng, C., Karimzadegan, S., Chiang, V., & Chalfie, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004017 · Cited by 28

H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1

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Ectopic DNMT3L Triggers Assembly of a Repressive Complex for Retroviral Silencing in Somatic Cells

Kao, T.-H., Liao, H., Wolf, D., Tai, K., Chuang, C.-Y., Lee, M., Kuo, H., Hata, K., Zhang, X., Cheng, X., et al. (2014) · Journal of Virology · doi:10.1128/jvi.01176-14 · Cited by 27

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

Piao, L., Nakakido, M., Suzuki, T., Dohmae, N., Nakamura, Y., & Hamamoto, R. (2016) · Oncotarget · doi:10.18632/oncotarget.8072 · Cited by 27

MicroRNA‐93 Regulates Hypoxia‐Induced Autophagy by Targeting ULK1

Li, W., Yang, Y., Ba, Z., Li, S., Chen, H., Hou, X., Ma, L., He, P., Jiang, L., Li, L., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2709053 · Cited by 27

On the relations of phase separation and Hi-C maps to epigenetics

Singh, P. B., & Newman, A. G. (2020) · Royal Society Open Science · doi:10.1098/rsos.191976 · Cited by 27

IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency

Xu, H., Li, X., Rousseau, B. A., Akinyemi, I. A., Frey, T. R., Zhou, K., Droske, L. E., Mitchell, J. A., McIntosh, M. T., & Bhaduri‐McIntosh, S. (2022) · Journal of Virology · doi:10.1128/jvi.01028-22 · Cited by 28

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer

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A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

Meylan, S., Groner, A. C., Ambrosini, G., Malani, N., Quenneville, S., Zangger, N., Kapopoulou, A., Kauzlaric, A., Rougemont, J., Ciuffi, A., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-378 · Cited by 27

AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling

Brasil, J. N., Cabral, L. M., Eloy, N. B., Primo, L. M. F., Barroso-Neto, I. L., Grangeiro, L. P. P., González, N., Inzé, D., Ferreira, P. C. G., & Hemerly, A. S. (2015) · BMC Plant Biology · doi:10.1186/s12870-015-0641-z · Cited by 27

TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues

Shibata, M., Blauvelt, K. E., Liem, K. F., & García‐García, M. J. (2011) · Development · doi:10.1242/dev.072546 · Cited by 29

Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

Song, W., Zsindely, N., Faragó, A., Marsh, J., & Bodai, L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx432 · Cited by 26

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression ofHoxa9andMeis1in acute myeloid leukemia

Ropa, J. P., Saha, N., Chen, Z., Serio, J., Chen, W., Mellacheruvu, D., Zhao, L., Basrur, V., Nesvizhskii, A. I., & Muntean, A. G. (2018) · Oncotarget · doi:10.18632/oncotarget.25204 · Cited by 29

Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2

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Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance

Pham, V., Pitti, R., Tindell, C. A., Cheung, T. K., Masselot, A., Stephan, J.-P., Guler, G. D., Wilson, C., Lill, J., Arnott, D., et al. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00773 · Cited by 26

Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages

Kunoh, S., Nakashima, H., & Nakashima, K. (2024) · Epigenomes · doi:10.3390/epigenomes8020022 · Cited by 33

Control of RUNX3 by histone methyltransferases

Lee, Y. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22969 · Cited by 26

Substitutions in the Amino-Terminal Tail of Neurospora Histone H3 Have Varied Effects on DNA Methylation

Adhvaryu, K. K., Berge, E., Tamaru, H., Freitag, M., & Selker, E. U. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002423 · Cited by 26

Maintaining memory of silencing at imprinted differentially methylated regions

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TRIM28 variants and Wilms' tumour predisposition

Hol, J. A., Diets, I. J., de Krijger, R. R., van den Heuvel‐Eibrink, M. M., Jongmans, M. C. J., & Kuiper, R. P. (2021) · The Journal of Pathology · doi:10.1002/path.5639 · Cited by 26

Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer

Waryah, C. B., Cursons, J., Foroutan, M., Pflueger, C., Wang, E., Molania, R., Woodward, E., Sorolla, A., Wallis, C. J. D., Moses, C., et al. (2023) · Advanced Science · doi:10.1002/advs.202301802 · Cited by 26

A comprehensive manually-curated compendium of bovine transcription factors

de Souza, M. M., Vaquerizas, J. M., Zerlotini, A., Geistlinger, L., Hernández-Rodríguez, B., Tizioto, P. C., Taylor, J. F., Rocha, M. I., Diniz, W. J. S., Coutinho, L. L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32146-2 · Cited by 26

COL11A2 Collagen Gene Transcription Is Differentially Regulated by EWS/ERG Sarcoma Fusion Protein and Wild-type ERG

Matsui, Y., Chansky, H. A., Barahmand-Pour, F., Zielinska‐Kwiatkowska, A., Tsumaki, N., Myoui, A., Yoshikawa, H., Yang, L., & Eyre, D. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300164200 · Cited by 26

Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression

Gao, H., Yu, Z., Bi, D., Jiang, L., Cui, Y., Sun, J., & Ma, R. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9525-3 · Cited by 26

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration

Lyu, Y., Kim, S., Humphrey, E., Nayak, R., Guan, Y., Liang, Q., Kim, K. H., Tan, Y., Dou, J., Sun, H., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.007 · Cited by 31

Comparison of ChIP-Seq Data and a Reference Motif Set for Human KRAB C2H2 Zinc Finger Proteins

Barazandeh, M., Lambert, S. A., Albu, M., & Hughes, T. R. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.300296 · Cited by 27

Trim24 and Trim33 Play a Role in Epigenetic Silencing of Retroviruses in Embryonic Stem Cells

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