SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Translating the Histone Code

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The language of covalent histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

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Regulation of Transcription by a Protein Methyltransferase

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

Tamaru, H., & Selker, E. U. (2001) · Nature · doi:10.1038/35104508 · Cited by 1,054

SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation

Južnić, L., Peuker, K., Strigli, A., Brosch, M., Herrmann, A., Häsler, R., Koch, M., Matthiesen, L., Zeißig, Y., Löscher, B.-S., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-321339 · Cited by 88

TIF1 Proteins in Genome Stability and Cancer

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Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1

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Hierarchical Inactivation of a Synthetic Human Kinetochore by a Chromatin Modifier

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DNA Methylation and Adult Neurogenesis

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A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiationPreprint

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Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

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TIF1δ, a Novel HP1-interacting Member of the Transcriptional Intermediary Factor 1 (TIF1) Family Expressed by Elongating Spermatids

Khetchoumian, K., Teletin, M., Mark, M. P., Lerouge, T., Cerviño, M., Oulad‐Abdelghani, M., Chambon, P., & Losson, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404779200 · Cited by 82

Sry Associates with the Heterochromatin Protein 1 Complex by Interacting with a KRAB Domain Protein1

Oh, H. J., Li, Y., & Lau, Y. C. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.034447 · Cited by 82

Trim28 Contributes to EMT via Regulation of E-Cadherin and N-Cadherin in Lung Cancer Cell Lines

Chen, L., Muñoz-Antonia, T., & Cress, W. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101040 · Cited by 83

The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia

Monaghan, L., Massett, M. E., Bunschoten, R. P., Hoose, A., Pirvan, P.-A., Liskamp, R. M. J., Jørgensen, H. G., & Huang, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00705 · Cited by 84

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway

Sun, Q., Ding, L., Xiao, J.-F., Chien, W., Lim, S. L., Hattori, N., Goodglick, L., Chia, D., Mah, V. H., Alavi, M., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4482 · Cited by 82

Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects

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The E2F family and the role of E2F1 in apoptosis

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Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genesPreprint

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Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

Klement, K., Luijsterburg, M. S., Pinder, J. B., Cena, C. S., Nero, V. D., Wintersinger, C. M., Dellaire, G., van Attikum, H., & Goodarzi, A. A. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201405077 · Cited by 79

Hijacking of transcriptional condensates by endogenous retroviruses

Asimi, V., Kumar, A. S., Niskanen, H., Riemenschneider, C., Hetzel, S., Naderi, J., Fasching, N., Popitsch, N. P., Du, M., Kretzmer, H., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01132-w · Cited by 79

Genome‐wide and locus‐specific DNA hypomethylation in G9a deficient mouse embryonic stem cells

Ikegami, K., Iwatani, M., Suzuki, M., Tachibana, M., Shinkai, Y., Tanaka, S., Greally, J. M., Yagi, S., Hattori, N., & Shiota, K. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.01029.x · Cited by 85

A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes

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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency

Sun, R., Liang, D., Gao, Y., & Lan, K. (2014) · Journal of Virology · doi:10.1128/jvi.00596-14 · Cited by 80

Chromatin and transcription: histones continue to make their marks

Jaskelioff, M., & Peterson, C. L. (2003) · Nature Cell Biology · doi:10.1038/ncb0503-395 · Cited by 81

Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline

Molaro, A., & Malik, H. S. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.12.001 · Cited by 80

H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

Olcina, M. M., Leszczyńska, K. B., Senra, J. M., Isa, N. F., Harada, H., & Hammond, E. M. (2015) · Oncogene · doi:10.1038/onc.2015.134 · Cited by 73

Dual Functions of Histone-Lysine N-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

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Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS.

Winter, D., Seidler, J., Ziv, Y., Shiloh, Y., & Lehmann, W. (2009) · Journal of Proteome Research · doi:10.1021/pr800304n · Cited by 75

Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9

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Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

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On your histone mark, SET, methylate!

Binda, O. (2013) · Epigenetics · doi:10.4161/epi.24451 · Cited by 78

The SCAN domain defines a large family of zinc finger transcription factors

Sander, T. L., Stringer, K. F., Maki, J. L., Szauter, P., Stone, J. R., & Collins, T. (2003) · Gene · doi:10.1016/s0378-1119(03)00509-2 · Cited by 76

Physical and functional interactions between STAT3 and KAP1

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The Epigenetic Control of the Transposable Element Life Cycle in Plant Genomes and Beyond

Liu, P., Cuerda-Gil, D., Shahid, S., & Slotkin, R. K. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072920-015534 · Cited by 69

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages.

Eames, H. L., Saliba, D. G., Krausgruber, T., Lanfrancotti, A., Ryzhakov, G., & Udalova, I. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.026 · Cited by 77

Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells

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KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction

Okamoto, K., Kitabayashi, I., & Taya, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.022 · Cited by 74

Should I stay or should I go: Protection and maintenance of DNA methylation at imprinted genes

Messerschmidt, D. M. (2012) · Epigenetics · doi:10.4161/epi.21337 · Cited by 82

The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses

Hummel, B., Hansen, E. C., Yoveva, A., Aprile-Garcia, F., Hussong, R., & Sawarkar, R. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3368 · Cited by 72

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

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Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

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Tri-methylation of ATF7IP by G9a/GLP recruits the chromodomain protein MPP8

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The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents

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Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity

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Primer Binding Site-Dependent Restriction of Murine Leukemia Virus Requires HP1 Binding by TRIM28

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The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity

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A Chemical Method for Labeling Lysine Methyltransferase Substrates

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Identification of a Functional Network of Human Epigenetic Silencing Factors

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KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral and Cellular Programs?

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Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells

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Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1

Kourmouli, N., Sun, Y.-M., van der Sar, S., Singh, P. B., & Brown, J. P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.132 · Cited by 71

The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies”

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Zinc finger 81 (ZNF81) mutations associated with X-linked mental retardation

Kleefstra, T., Yntema, H. G., Oudakker, A. R., Banning, M. J. G., Kalscheuer, V. M., Chelly, J., Moraine, C., Ropers, H.-H., Fryns, J.-P., Janssen, I. M., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.016972 · Cited by 71

SETDB1 in cancer: overexpression and its therapeutic implications.

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Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

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An Insight into Reprogramming Barriers to iPSC Generation

Haridhasapavalan, K. K., Raina, K., Dey, C., Adhikari, P., & Thummer, R. P. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09931-1 · Cited by 70

Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements

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The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances

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Epigenetic Gene Silencing by the SRY Protein Is Mediated by a KRAB-O Protein That Recruits the KAP1 Co-repressor Machinery*

Peng, H.-Z., Ivanov, A., Oh, H., Lau, Y.-F. C., & Rauscher, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032086 · Cited by 75

Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation

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Emerging role of SETDB1 as a therapeutic target

Karanth, A. V., Maniswami, R. R., Prashanth, S., Govindaraj, H., Padmavathy, R., Jegatheesan, S. K., Mullangi, R., & Rajagopal, S. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1279604 · Cited by 69

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons

Zhao, S., Lu, J., Pan, B., Fan, H., Byrum, S. D., Xu, C., Kim, A., Guo, Y., Kanchi, K., Gong, W., et al. (2023) · Nature · doi:10.1038/s41586-023-06688-z · Cited by 65

H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

Wu, P., Lu, J., Yang, J., Lin, I., Ou, D., Lin, Y., Chou, K.-H., Huang, W., Wang, W.-P., Huang, Y., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3572 · Cited by 69

Windei, the Drosophila Homolog of mAM/MCAF1, Is an Essential Cofactor of the H3K9 Methyl Transferase dSETDB1/Eggless in Germ Line Development

Koch, C., Honemann‐Capito, M., Egger‐Adam, D., & Wodarz, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000644 · Cited by 70

MBD2 and MBD3: elusive functions and mechanisms

Menafra, R., & Stunnenberg, H. G. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00428 · Cited by 67

Dynamics of inherently bounded histone modification domains

Hodges, H. C., & Crabtree, G. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211172109 · Cited by 64

Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies

Kristie, T. M. (2015) · Virology · doi:10.1016/j.virol.2015.01.026 · Cited by 67

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

Jiang, Y., Liu, Y., Li, J., Sun, S., Jin, W., Wang, X., & Dong, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03852-2 · Cited by 71

SETDB1 regulates SMAD7 expression for breast cancer metastasis

Ryu, T. Y., Kim, K., Kim, S., Oh, J., Min, J., Jung, C., Son, M., Kim, D., & Cho, H. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.2.235 · Cited by 68

TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks

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Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

Boulias, K. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh947 · Cited by 66

Rush hour at the promoter: How the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription

Dennis, A. P., & O’Malley, B. W. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.015 · Cited by 70

HP1 Recruits Activity-Dependent Neuroprotective Protein to H3K9me3 Marked Pericentromeric Heterochromatin for Silencing of Major Satellite Repeats

Mosch, K., Franz, H., Soeroes, S., Singh, P. B., & Fischle, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015894 · Cited by 66

Kaposi's Sarcoma-Associated Herpesvirus Kaposin B Induces Unique Monophosphorylation of STAT3 at Serine 727 and MK2-Mediated Inactivation of the STAT3 Transcriptional Repressor TRIM28

King, C. A. (2013) · Journal of Virology · doi:10.1128/jvi.02976-12 · Cited by 71

Neuroepigenetic mechanisms in disease

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Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors

Qin, P., Lu, S., Shi, Y., Pan, Y., Limsakul, P., Chernov, A. V., Qiu, J., Chai, X., Shi, Y., Wang, P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811818115 · Cited by 64

Histone modifications as key regulators of transcription

Asad, U. K. (2005) · Frontiers in bioscience · doi:10.2741/1580 · Cited by 67

Controlling gene expression in plants using synthetic zinc finger transcription factors

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Jarid2 (Jumonji, AT Rich Interactive Domain 2) Regulates NOTCH1 Expression via Histone Modification in the Developing Heart

Mysliwiec, M. R., Carlson, C. D., Tietjen, J. R., Hung, H. A., Ansari, A. Z., & Lee, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.315945 · Cited by 65

Methods and tips for the purification of human histone methyltransferases

Nishioka, K. (2003) · Methods · doi:10.1016/s1046-2023(03)00087-2 · Cited by 66

Sumoylation of the Transcriptional Intermediary Factor 1β (TIF1β), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain

Mascle, X. H., Germain-Desprez, D., Huynh, P. T., Estephan, P., & Aubry, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611429200 · Cited by 65

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion

Ying-hao, S. U. N., Sun, Y., Wei, M., Ren, S., Chen, R., Xu, W., Wang, F., Lu, J., Shen, J. G., Yu, Y.-W., et al. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122812 · Cited by 64

TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells

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Gene expression in breast muscle associated with feed efficiency in a single male broiler line using a chicken 44K oligo microarray. I. Top differentially expressed genes

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DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins

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Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53

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The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis

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ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

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SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle

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ZNF274 Recruits the Histone Methyltransferase SETDB1 to the 3′ Ends of ZNF Genes

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Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs

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