SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Translating the Histone Code

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The language of covalent histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

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Regulation of Transcription by a Protein Methyltransferase

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A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

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TRIM involvement in transcriptional regulation.

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Identification and Characterization of ZFP-57, a Novel Zinc Finger Transcription Factor in the Mammalian Peripheral Nervous System

Alonso, M. B. D., Zoidl, G., Taveggia, C., Bosse, F., Zoidl, C., Rahman, M., Parmantier, E., Dean, C. H., Harris, B. S., Wrabetz, L. G., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400415200 · Cited by 23

Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP

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Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis

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Stellate Genes and the piRNA Pathway in Speciation and Reproductive Isolation of Drosophila melanogaster

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KAP1-independent transcriptional repression of SCAN-KRAB-containing zinc finger proteins.

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Domains of Heterochromatin Protein 1 Required forDrosophila melanogasterHeterochromatin Spreading

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Gene silencing in phenomena related to DNA repair

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A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line

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Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas

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Enhanced Expression of Human Endogenous Retroviruses, TRIM28 and SETDB1 in Autism Spectrum Disorder

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Genetic Studies on Mammalian DNA Methyltransferases

Dan, J., & Chen, T. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11454-0_5 · Cited by 23

RNA‐mediated heterochromatin formation at repetitive elements in mammals

Stamidis, N., & Żylicz, J. J. (2023) · The EMBO Journal · doi:10.15252/embj.2022111717 · Cited by 26

Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1

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Human factors and pathways essential for mediating epigenetic gene silencing

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Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1

Calderon, M. R., Verway, M. J., Benslama, R. O., Birlea, M., Bouttier, M., Dimitrov, V., Mader, S., & White, J. H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku413 · Cited by 23

Epigenetic Control of Early Mouse Development

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The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi’s sarcoma-associated herpesvirus RTA-mediated gene expression

Yang, Z.-L., Wen, H.-J., Minhas, V., & Wood, C. (2009) · Virology · doi:10.1016/j.virol.2009.06.014 · Cited by 24

Requirements for establishment and epigenetic stability of mammalian heterochromatin

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Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells

Singh, N., Ramírez-Carvajal, L., Santos, T. D. L., Golding, M. C., & Long, C. R. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0006 · Cited by 21

The effects of biological aging on global DNA methylation, histone modification, and epigenetic modifiers in the mouse germinal vesicle stage oocyte

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The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease

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Landscape of evolutionary arms races between transposable elements and KRAB-ZFP family

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Evolutionary history and epigenetic regulation of the three paralogous pax7 genes in rainbow trout

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Breaking through an epigenetic wall

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The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling

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Role of genome guardian proteins in transcriptional elongation

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Epigenetics and Disease

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Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5α and 22

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Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response

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Paternally Expressed Peg3 Controls Maternally Expressed Zim1 as a Trans Factor

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Transcriptional enhancers: from prediction to functional assessment on a genome-wide scale

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TRIM28 Regulates Dlk1 Expression in Adipogenesis

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Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections

Asha, K., & Sharma-Walia, N. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.603309 · Cited by 20

Kruppel-associated box (KRAB) proteins in the adaptive immune system

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Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus

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Alterations of Histone Modifications in Cancer

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Regulation And Function Of H3K9 Methylation

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The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene

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TRIM28/KAP1 regulates senescence

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Eukaryotic Methyl-CpG-Binding Domain Proteins and Chromatin Modification

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Erratum: Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation

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Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box

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Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy

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Identification and characterization of the first fragment hits for SETDB1 Tudor domain

Mäder, P., Mendoza‐Sanchez, R., Iqbal, A., Dong, A., Dobrovetsky, E., Corless, V. B., Liew, S. K., Houliston, S., de Freitas, R. F., Smil, D. V., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.07.020 · Cited by 19

Balance between Retroviral Latency and Transcription: Based on HIV Model

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Rewiring of chromatin state and gene expression by transposable elements

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Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

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Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response

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Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease

Tovo, P., Ribaldone, D. G., Galliano, I., Caviglia, G. P., Dini, M., Veglio, V., Calvi, C., Montanari, P., Pitoni, D., Frara, S., et al. (2024) · Viruses · doi:10.3390/v16101570 · Cited by 20

Signal transducer and activator of transcription 3 regulation by novel binding partners

Matsuda, T. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.324 · Cited by 19

SETDB1-mediated FosB regulation via ERK2 is associated with an increase in cell invasiveness during anticancer drug treatment of A549 human lung cancer cells

Na, H.-H., & Kim, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.176 · Cited by 19

Genome‐wide chromatin occupancy of BRDT and gene expression analysis suggest transcriptional partners and specific epigenetic landscapes that regulate gene expression during spermatogenesis

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Silencing of the I l2 gene transcription is regulated by epigenetic changes in anergic T cells

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KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies

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A novel Kr�ppel-associated box identified in a panel of mammalian zinc finger proteins

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The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

Miyagi, S., Koide, S., Saraya, A., Wendt, G. R., Oshima, M., Konuma, T., Yamazaki, S., Mochizuki‐Kashio, M., Nakajima‐Takagi, Y., Wang, C., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.12.008 · Cited by 20

Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia

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The Krüppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

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X-linked mental retardation and epigenetics

Froyen, G., Bauters, M., Voet, T., & Marynen, P. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00526.x · Cited by 19

Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma

McGeary, M. K., Damsky, W., Daniels, A. J., Lang, S. M., Xu, Q., Song, E., Huet-Calderwood, C., Lou, H. J., Paradkar, S., Micevic, G., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0514 · Cited by 19

Surveillance of Retroelement Expression and Nucleic‐Acid Immunity by Histone Methyltransferase SETDB1

Kang, Y. (2018) · BioEssays · doi:10.1002/bies.201800058 · Cited by 18

All Quiet on the TE Front? The Role of Chromatin in Transposable Element Silencing

Di Stefano, L. (2022) · Cells · doi:10.3390/cells11162501 · Cited by 18

Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation

Garcia, P., Jarassier, W., Brun, C. E., Giordani, L., Agostini, F., Kung, W. H., Peccate, C., Ravent, J., Fall, S., Petit, V., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.012 · Cited by 20

Therapeutic Inhibition of LincRNA-p21 Protects against Cardiac Hypertrophy

Wang, Y., Zhang, M., Wang, R., Lin, J.-X., Ma, Q., Guo, H., Huang, H.-H., Liang, Z.-M., Cao, Y.-P., Zhang, X.-R., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.323356 · Cited by 17

Role of several histone lysine methyltransferases in tumor development

Li, J., Zhu, S., Ke, X., & Cui, H. (2016) · Biomedical Reports · doi:10.3892/br.2016.574 · Cited by 19

TRIM Proteins and the Innate Immune Response to Viruses

Yap, M. W., & Stoye, J. P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5398-7_7 · Cited by 18

KRAB Can Repress Lentivirus Proviral Transcription Independently of Integration Site

Bulliard, Y., Wiznerowicz, M., Barde, I., & Trono, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602843200 · Cited by 18

Spatial distribution of histone methylation during MHC class II expression

Chou, S., & Tomasi, T. B. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.07.039 · Cited by 18

Cultural relativism: maintenance of genomic imprints in pluripotent stem cell culture systems

Greenberg, M., & Bourc’his, D. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.04.005 · Cited by 19

Histone Methyltransferase SETDB1 Regulates the Development of Cortical Htr3a-Positive Interneurons and Mood Behaviors

Li, J., Zheng, S., Dong, Y., Xu, H., Zhu, Y., Weng, J., Sun, D., Wang, S., Xiao, L., & Jiang, Y. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.08.021 · Cited by 17

Mapping the interaction between Trim28 and the KRAB domain at the center of Trim28 silencing of endogenous retroviruses

Taka, J. R. H., Sun, Y., & Goldstone, D. C. (2022) · Protein Science · doi:10.1002/pro.4436 · Cited by 15

Chromatin control of human cytomegalovirus infection

Matthews, S. M., Groves, I. J., & O’Connor, C. M. (2023) · mBio · doi:10.1128/mbio.00326-23 · Cited by 17

How calorie restriction slows aging: an epigenetic perspective

Lim, G. M., Maharajan, N., & Cho, G.-W. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02430-y · Cited by 19

Human Endogenous Retroviruses as Novel Therapeutic Targets in Neurodegenerative Disorders

Simula, E. R., Jasemi, S., Cossu, D., Fais, M., Cossu, I., Chessa, V., Canu, M., & Sechi, L. A. (2025) · Vaccines · doi:10.3390/vaccines13040415 · Cited by 19

PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

Lee, S.-J., Lee, J.-R., Hah, H.-S., Kim, Y.-H., Ahn, J., Bae, C., Yang, J., & Hahn, M. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.49 · Cited by 17

Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation

Lee, M., Dworkin, A. M., Lichtenberg, J., Patel, S. J., Trivedi, N. S., Gildea, D. E., Bodine, D. M., & Crawford, N. P. S. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0167 · Cited by 19

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

Huang, J., Huang, W., Liu, M., Zhu, J., Jiang, D., Xiong, Y., Zhen, Y., Yang, D., Chen, Z., Peng, L., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6490 · Cited by 17

KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5

Caprio, R. D., Ciano, M., Montano, G., Costanzo, P., & Cesaro, E. (2015) · Biology · doi:10.3390/biology4010041 · Cited by 17

PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies

Fleischer, S., Wiemann, S., Will, H., & Hofmann, T. G. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.12.005 · Cited by 17

Deciphering the epigenetic code of T lymphocytes

Allan, R. S., & Nutt, S. L. (2014) · Immunological Reviews · doi:10.1111/imr.12207 · Cited by 18

The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes

Ma, X., Chao, S.-B., Huang, X., Lin, F., Qin, L., Wang, X., Meng, T., Zhu, C., Schatten, H., Liu, H., et al. (2015) · Scientific Reports · doi:10.1038/srep17924 · Cited by 16

Genome-editing tools for stem cell biology

Vasileva, E., Shuvalov, O. Y., Garabadgiu, A. V., Melino, G., & Barlev, N. A. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.167 · Cited by 19

Cavitation Enhancement Increases the Efficiency and Consistency of Chromatin Fragmentation from Fixed Cells for Downstream Quantitative Applications

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