The cellular mechanisms of memory are modified by experience
Open accessAbstract
The N-methyl-D-aspartate receptor (NMDAR) is thought to be essential for synaptic plasticity and learning. However, recent work indicates that the role of this receptor depends on the prior history of the research subject. For example, animals trained on a hippocampus-dependent learning task are subsequently able to acquire new information in the absence of NMDAR activation. The current experiments were designed to identify the types of experiences that lead to NMDAR-independent learning. Using contextual fear conditioning in mice, we find that NMDAR-independent learning is only observed when (1) animals are trained on the same behavioral task and (2) initial learning is successfully encoded into long-term memory.
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In adult animals, first-time task learning is dependent on activation of NMDA receptors but later task relearning is not.
“One study (144) used the fact that, in adult animals, first-time task learning is dependent on activation of N-methyl-d-aspartate (NMDA) receptors (145) but later task relearning is not (146).”
From The Stress Acceleration Hypothesis of Nightmares (2017) · cites this paper as [146]
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- Authors
- Wiltgen, B. J., Wood, A. N., & Levy, B.
- Affiliations
- University of Virginia (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-11-15
- Volume
- 18
- Issue
- 12
- Pages
- 747-750
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W2114637907
- Cited by
- 18
- References
- 26
- Citations by year
- 2022: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Thomas F. and Kate Miller Jeffress Memorial Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- NMDA receptor, synaptic plasticity, long-term memory, contextual fear conditioning, hippocampus-dependent learning, prior experience, memory encoding, mice
- MeSH terms
- Animals, Brain, Conditioning, Classical, Learning, Memory, Receptors, N-Methyl-D-Aspartate, Mice
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