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Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events

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Kitamura, Takashi, Macdonald, Christopher J., Tonegawa, Susumu·2015·Learning & Memory
DOI 10.1101/lm.038687.115PMC PMC4561404
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Abstract

The entorhinal cortex (EC)–hippocampal (HPC) network plays an essential role for episodic memory, which preserves spatial and temporal information about the occurrence of past events. Although there has been significant progress toward understanding the neural circuits underlying the spatial dimension of episodic memory, the relevant circuits subserving the temporal dimension are just beginning to be understood. In this review, we examine the evidence concerning the role of the EC in associating events separated by time—or temporal associative learning—with emphasis on the function of persistent activity in the medial entorhinal cortex layer III (MECIII) and their direct inputs into the CA1 region of HPC. We also discuss the unique role of Island cells in the medial entorhinal cortex layer II (MECII), which is a newly discovered direct feedforward inhibitory circuit to CA1. Finally, we relate the function of these entorhinal cortical circuits to recent findings concerning hippocampal time cells, which may collectively activate in sequence to bridge temporal gaps between discontiguous events in an episode.

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  • The hippocampal pallium of teleost fish is critical for the temporal dimension of associative memories required for trace classical conditioning.

    “These deficits are strikingly similar to those reported in hippocampal-lesioned mammals [216,226,227,228,229,230,231], and reveal that the hippocampal pallium of teleost fish is critical for the temporal dimension of the associative memories required for trace classical conditioning.”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [226]

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Cited by

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Authors
Kitamura, T., Macdonald, C. J., & Tonegawa, S.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Tonegawa, Susumu
ORCID
Venue
Learning & Memory
Publisher
Cold Spring Harbor Laboratory
Published
2015-08-18
Volume
22
Issue
9
Pages
438-443
ISSN
  • 1072-0502 (ISSN-L)
  • 1549-5485
DOI
10.1101/lm.038687.115
PMC
PMC4561404
OpenAlex
W1869067307
Cited by
105
References
14
Citations by year
2026: 6 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 17 · 2018: 7 · 2017: 11 · 2016: 4
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Learning & Memory (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • RIKEN Brain Science Institute
  • Howard Hughes Medical Institute
  • JPB Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
entorhinal cortex, hippocampus, episodic memory, persistent activity, CA1, feedforward inhibition, neural circuits
MeSH terms
Animals, Association Learning, Hippocampus, Humans, Neural Pathways, Time Perception, Entorhinal Cortex

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