D-cycloserine potentiates the reconsolidation of cocaine-associated memories
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Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-associated stimuli through facilitation of extinction. Here we show that intrabasolateral amygdala infusions of D-cycloserine in fact potentiate the reconsolidation of stimulus-cocaine memories to increase cue-induced relapse to drug seeking in rats with an extensive drug self-administration history. This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268.
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Insufficient exposure may set the stage for reconsolidation of active fear memories, and DCS may enhance these adverse reconsolidation effects, leading to poorer outcome relative to placebo.
“Moreover, insufficient exposure may also set the stage for reconsolidation of active fear memories (23), and there is evidence that DCS may be able to enhance these adverse reconsolidation effects as well, leading to poorer outcome relative to placebo administration, as potentially observed in this and other studies (9, 24).”
From D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: evidence from the treatment of height phobia (2013) · cites this paper as [24]
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Essmat, N., Boldizsár, I., Chalabiani, Y., Varga, B. T., Abbood, S. K., Kirchlechner-Farkas, J. M., Király, K. P., Miklya, I., Gyertyán, I., Tábi, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110526 · Cited by 1 · see citing works
ReconsolidationofaCocaine-AssociatedStimulusRequires AmygdalarProteinKinaseA
Quinn, J. T., & Torregrossa, M. M. (2010)
- Authors
- Lee, J. L. C., Gardner, R. J., Butler, V. J., & Everitt, B. J.
- Affiliations
- University of Cambridge (GB)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-01
- Volume
- 16
- Issue
- 1
- Pages
- 82-85
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC2632849
- OpenAlex
- W2134034874
- Cited by
- 70
- References
- 41
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 11 · 2012: 15
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Medical Research Council (9536855)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- D-cycloserine, cocaine, memory reconsolidation, relapse, drug-seeking behavior, conditioned stimulus, basolateral amygdala, extinction, Zif268, drug addiction treatment, glutamate receptor modulation
- MeSH terms
- Amygdala, Animals, Antimetabolites, Cocaine, Conditioning, Operant, Cues, Cycloserine, Drug Synergism, Extinction, Psychological, Male, Memory, Microinjections, Mental Recall, Recurrence, Cocaine-Related Disorders, Rats
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