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Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts
Open accessAbstract
Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.
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“The OPP test has been shown to be hippocampus-dependent in rodents (Barker and Warburton, 2011b; Mumby et al., 2002).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Mumby et al., 2002
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Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Beaton, A. E., & Keppel, G. (1975) · American Educational Research Journal · doi:10.2307/1162588 · Cited by 5,857
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Aggleton, J. P., & Brown, M. W. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002034 · Cited by 1,879
A cortical–hippocampal system for declarative memory
Eichenbaum, H. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036213 · Cited by 1,817
Two functional components of the hippocampal memory system
Eichenbaum, H., Otto, T., & Cohen, N. J. (1994) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00035391 · Cited by 1,114
The hippocampus and contextual retrieval of information from memory: A theory
Hirsh, R. (1974) · Behavioral Biology · doi:10.1016/s0091-6773(74)92231-7 · Cited by 957
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740
Design and analysis: A researcher's handbook, 3rd ed.
Keppel, G. (1991) · Cited by 703
Ennaceur, A., Neave, N., & Aggleton, J. P. (1997) · Experimental Brain Research · doi:10.1007/pl00005603 · Cited by 670
Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.1093 · Cited by 615
Dix, S. L., & Aggleton, J. P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00079-5 · Cited by 612
Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat
Sutherland, R. J., Kolb, B. E., & Whishaw, I. Q. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90032-5 · Cited by 542
The effects of hippocampal lesions upon spatial and non-spatial tests of working memory
Aggleton, J. P., Hunt, P. R., & Rawlins, J. N. P. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90011-2 · Cited by 500
A two-trial memory task with automated recording: study in young and aged rats
Dellu, F., Mayo, W., Cherkaoui, J., Le Moal, M., & Simon, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91352-f · Cited by 390
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356
Ennaceur, A., Neave, N., & Aggleton, J. P. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00006-x · Cited by 351
Kesner, R., Bolland, B. L., & Dakis, M. (1993) · Experimental Brain Research · doi:10.1007/bf00229361 · Cited by 324
Maren, S., & Fanselow, M. S. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3752 · Cited by 324
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.19 · Cited by 240
Mumby, D. G., Wood, E. R., & Pinel, J. P. J. (1992) · Psychobiology · doi:10.3758/bf03327156 · Cited by 219
Young, S. L., Bohenek, D. L., & Fanselow, M. S. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.19 · Cited by 184
The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats
Shaw, C., & Aggleton, J. P. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90051-q · Cited by 181
Object recognition memory in the rat: the role of the hippocampus
Rothblat, L. A., & Kromer, L. F. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80036-1 · Cited by 167
Hippocampal lesions and path integration
Whishaw, I. Q., McKenna, J. E., & Maaswinkel, H. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80011-6 · Cited by 167
Rawlins, J. N. P., Lyford, G. L., Seferiades, A., Deacon, R. M. J., & al, E. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.3.420 · Cited by 158
Rats with lesions of the hippocampus are impaired on the delayed nonmatching‐to‐sample task†
Clark, R. E., West, A. N., Zola, S. M., & Squire, L. R. (2001) · Hippocampus · doi:10.1002/hipo.1035 · Cited by 135
Warburton, E. C., & Aggleton, J. P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00047-3 · Cited by 127
Rawlins, J. N. P., Lyford, G. L., Seferiades, A., et al. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.3.420 · Cited by 123
Spontaneous recognition of object configurations in rats: effects of fornix lesions
Ennaceur, A., & Aggleton, J. P. (1994) · Experimental Brain Research · doi:10.1007/bf00227281 · Cited by 119
Duva, C. A., Floresco, S., Wunderlich, G. R., Lao, T. L., Pinel, J. P. J., & Phillips, A. G. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.6.1184 · Cited by 111
Recognition memory in rats—II. Neuroanatomical substrates
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A., & Aggleton, J. P. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00061-0 · Cited by 108
Save, É., Buhot, M.-C., Foreman, N., & Thinus‐Blanc, C. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80118-4 · Cited by 108
Mumby, D. G., Wood, E. R., Duva, C. A., Kornecook, T. J., Pinel, J. P. J., & Phillips, A. G. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.266 · Cited by 93
Nadel, L., & Bohbot, V. D. (2001) · Hippocampus · doi:10.1002/1098-1063(2001)11:1 · Cited by 92
Continuous recognition of spatial and nonspatial stimuli in hippocampal-lesioned rats
Jackson-Smith, P. A., Kesner, R. P., & Chiba, A. A. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)90821-x · Cited by 91
Wiig, K. A., & Bilkey, D. K. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.4.620 · Cited by 91
Yee, B., & Rawlins, J. N. P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03766.1994 · Cited by 89
The hippocampus, objects, and their contexts.
Cassaday, H. J., & Rawlins, J. N. P. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.6.1228 · Cited by 82
Wiig, K. A., & Bilkey, D. K. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.620 · Cited by 71
Mumby, D. G., Pinel, J. P. J., Kornecook, T. J., Shen, M. J., & Redila, V. A. (1995) · Psychobiology · doi:10.3758/bf03327055 · Cited by 65
Animal models of medial temporal lobe amnesia: The myth of the hippocampus.
Duva, C. A., Kornecook, T. J., & Pinel, J. P. J. (2004) · American Psychological Association eBooks · doi:10.1037/10335-012 · Cited by 3
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The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464
Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909
“An exploration ratio was calculated (exploration ratio = freq. smell #3/(freq. smell #3 + freq. smell #2B)×100).”
Method
Metadata
- Authors
- Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H.
- Affiliations
- Concordia University (CA)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-03-01
- Volume
- 9
- Issue
- 2
- Pages
- 49-57
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC155935
- OpenAlex
- W2024032885
- Cited by
- 714
- References
- 44
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 19 · 2023: 24 · 2022: 28 · 2021: 26 · 2020: 36 · 2019: 34 · 2018: 37 · 2017: 28 · 2016: 36 · 2015: 30 · 2014: 49 · 2013: 43 · 2012: 55
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Keywords
- hippocampal lesions, novelty preference, object recognition memory, place memory, contextual memory, spatial memory, hippocampal formation, rats, cytotoxic lesions, memory impairment
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Exploratory Behavior, Hippocampus, Male, Memory, Pattern Recognition, Visual, Space Perception, Rats, Long-Evans, Rats
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