Cited by 127Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 261 of the 261 references it cites were found in a registry or an index.

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

Open access

Hains, Avis B., Arnsten, Amy F.T.·2008·Learning & Memory

DOI 10.1101/lm.921708

Open this paper in CoChat — free account Open PDF

Abstract

The symptoms of mental illness often involve weakened regulation of thought, emotion, and behavior by the prefrontal cortex. Exposure to stress exacerbates symptoms of mental illness and causes marked prefrontal cortical dysfunction. Studies in animals have revealed the intracellular signaling pathways activated by stress exposure that induce profound prefrontal cortical impairment: Excessive dopamine stimulation of D1 receptors impairs prefrontal function via cAMP intracellular signaling, leading to disconnection of prefrontal networks, while excessive norepinephrine stimulation of α1 receptors impairs prefrontal function via phosphatidylinositol–protein kinase C intracellular signaling. Genetic studies indicate that the genes disrupted in serious mental illness (bipolar disorder and schizophrenia) often encode for the intracellular proteins that serve as brakes on the intracellular stress pathways. For example, disrupted in schizophrenia 1 (DISC1) normally regulates cAMP levels, while regulator of G protein signaling 4 (RGS4) and diacylglycerol kinase (DGKH)—the molecule most associated with bipolar disorder— normally serve to inhibit phosphatidylinositol–protein kinase C intracellular signaling. Patients with mutations resulting in loss of adequate function of these genes likely have weaker endogenous regulation of these stress pathways. This may account for the vulnerability to stress and the severe loss of PFC regulation of behavior, thought, and affect in these illnesses. This review highlights the signaling pathways onto which genetic vulnerability and stress converge to impair PFC function and induce debilitating symptoms such as thought disorder, disinhibition, and impaired working memory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/lm.921708

Cites

261 of 261 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Conflict monitoring and cognitive control
Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663

Flagged first, then by citations

Show all 261 references

Research works printed but not linked: 2

American Psychological Association (2000) Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV) (American Psychiatric Press, Inc. Washington, DC).
10.1162/jocn.2008.20.3.447 · DOI

Sorted by citations

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue
Brisch, R., Saniotis, A., Wolf, R. J., Bielau, H., Bernstein, H., Steiner, J. H., Bogerts, B., Braun, A. K., Jankowski, Z., Kumaritlake, J., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00047 · Cited by 575
Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Feng, J., McEwen, B. S., & Yan, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906791106 · Cited by 481
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment
Edmiston, E. E. (2011) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2011.565 · Cited by 341
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.50 · Cited by 324
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1
Jaaro-Peled, H., Hayashi‐Takagi, A., Seshadri, S., Kamiya, A., Brandon, N. J., & Sawa, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.007 · Cited by 322
A Discrete GABAergic Relay Mediates Medial Prefrontal Cortical Inhibition of the Neuroendocrine Stress Response
Radley, J. J., Gosselink, K. L., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-08.2009 · Cited by 273
Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability
Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
Hains, A. B., Vu, M. A. T., Maciejewski, P. K., van Dyck, C. H., Gottron, M., & Arnsten, A. F. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908563106 · Cited by 234
Self-citation
A role for white matter abnormalities in the pathophysiology of bipolar disorder
Mahon, K., Burdick, K. E., & Szeszko, P. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.012 · Cited by 231
A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
Potkin, S. G., Turner, J. A., Guffanti, G., Lakatos, A., Fallon, J. H., Nguyen, D. D., Mathalon, D. H., Ford, J. M., Lauriello, J., & Macciardi, F. M. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn155 · Cited by 222
DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress
Yao, B., Cheng, Y., Wang, Z., Li, Y., Chen, L., Huang, L., Zhang, W., Chen, D., Wu, H., Tang, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01195-y · Cited by 217
Technostress and the hierarchical levels of personality: a two-wave study with multiple data samples
Maier, C., Laumer, S., Wirth, J., & Weitzel, T. (2019) · European Journal of Information Systems · doi:10.1080/0960085x.2019.1614739 · Cited by 235
A transdiagnostic minority stress treatment approach for gay and bisexual men's syndemic health conditions
Pachankis, J. E. (2015) · Archives of Sexual Behavior · doi:10.1007/s10508-015-0480-x · Cited by 205
Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression
Ghosal, S., Hare, B. D., & Duman, R. S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.09.012 · Cited by 213
Stress-Related Methylation of the Catechol- O -Methyltransferase Val 158 Allele Predicts Human Prefrontal Cognition and Activity
Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., Sinibaldi, L., Gelao, B., Romano, R., Rampino, A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6631-10.2011 · Cited by 188
Dynamic multi-coil shimming of the human brain at 7T
Juchem, C., Nixon, T. W., McIntyre, S., Boer, V. O., Rothman, D. L., & de Graaf, R. A. (2011) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2011.07.005 · Cited by 151
Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?
Atzori, M., Cuevas‐Olguin, R., Esquivel‐Rendon, E., García‐Oscos, F., Salgado‐Delgado, R., Saderi, N., Miranda‐Morales, M., Treviño, M., Pineda, J. C., & Salgado, H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00025 · Cited by 156
Environmental enrichment, prefrontal cortex, stress, and aging of the brain
Segovia, G., Arco, A. D., & Mora, F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0214-0 · Cited by 140
Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice
Spadaro, P. A., Flavell, C. R., Widagdo, J., Ratnu, V. S., Troup, M., Ragan, C., Mattick, J. S., & Bredy, T. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.004 · Cited by 130
When Does Stress Help or Harm? The Effects of Stress Controllability and Subjective Stress Response on Stroop Performance
Henderson, R. K., Snyder, H. R., Gupta, T., & Banich, M. (2012) · Front. Psychology · doi:10.3389/fpsyg.2012.00179 · Cited by 129
The effects of aerobic exercise intensity on memory in older adults
Kovačević, A., Fenesi, B., Paolucci, E. M., & Heisz, J. J. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0495 · Cited by 131
Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals
Floresco, S., & Jentsch, J. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.158 · Cited by 120
Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep‐deprived rats
Chang, H., Wu, U., & Lan, C. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00704.x · Cited by 106
Individual Differences in Delay Discounting Under Acute Stress: The Role of Trait Perceived Stress
Lempert, K. M., Porcelli, A. J., Delgado, M. R., & Tricomi, E. M. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00251 · Cited by 112
Impairments of Spatial Working Memory and Attention Following Acute Psychosocial Stress: Psychosocial Stress and Cognition
Olver, J. S., Pinney, M., Maruff, P., & Norman, T. R. (2015) · Stress and Health · doi:10.1002/smi.2533 · Cited by 114
Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia
Meyer, U., & Feldon, J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1504-9 · Cited by 103
The noradrenergic paradox: implications in the management of depression and anxiety
Montoya, A., Bruins, R., Katzman, M. A., & Blier, P. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s91311 · Cited by 99
The effects of arousal on apical amplification and conscious state
Phillips, W. A., Larkum, M. E., Harley, C. W., & Silverstein, S. M. (2016) · Neuroscience of Consciousness · doi:10.1093/nc/niw015 · Cited by 75
Critical brain circuits at the intersection between stress and learning
Bangasser, D. A., & Shors, T. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.002 · Cited by 83
Anxiety Evokes Hypofrontality and Disrupts Rule-Relevant Encoding by Dorsomedial Prefrontal Cortex Neurons
Park, J., Wood, J. T., Bondi, C. O., Arco, A. D., & Moghaddam, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4250-15.2016 · Cited by 78
Prefrontal modulation of anxiety through a lens of noradrenergic signaling
Bouras, N. N., Mack, N. R., & Gao, W. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1173326 · Cited by 88
Dynamic Multi-Coil Technique (DYNAMITE) Shimming for Echo-Planar Imaging of the Human Brain at 7 Tesla
Juchem, C., Umesh Rudrapatna, S., Nixon, T. W., & de Graaf, R. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.11.011 · Cited by 74
Neurotransmitter Targeting in the Treatment of Depression
Blier, P. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12084su1c.04 · Cited by 74
Enduring deficits in contextual and auditory fear conditioning after adolescent, not adult, social instability stress in male rats
Morrissey, M. D., Zovkic, I. B., & McCormick, C. M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.10.007 · Cited by 78
Fgfr2Is Required for the Development of the Medial Prefrontal Cortex and Its Connections with Limbic Circuits
Stevens, H. E., Smith, K. M., Maragnoli, M. E., Fagel, D. M., Borok, E., Shanabrough, M., Horváth, T. L., & Vaccarino, F. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5837-09.2010 · Cited by 72
Magnetic field homogenization of the human prefrontal cortex with a set of localized electrical coils
Juchem, C., Nixon, T. W., McIntyre, S., Rothman, D. L., & de Graaf, R. A. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22164 · Cited by 72
Early life adversity alters the developmental profiles of addiction-related prefrontal cortex circuitry
Brenhouse, H., Lukkes, J., & Andersen, S. (2013) · Brain Sciences · doi:10.3390/brainsci3010143 · Cited by 68
Widespread Cortical Dysfunction in Schizophrenia: The FBIRN Imaging Consortium
Potkin, S. G., & Ford, J. M. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn159 · Cited by 71
The noradrenergic symptom cluster: clinical expression and neuropharmacology
Briley, M., & Blier, P. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s19613 · Cited by 66
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease
Dong, H., Murphy, K. M., Meng, L., Montalvo‐Ortiz, J. L., Zeng, Z., Kolber, B. J., Zhang, S., Muglia, L. J., & Csernansky, J. G. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111328 · Cited by 62
Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories
Garrido, P., de Blas, M., Ronzoni, G., Cordero, I., Antón, M., Giné, E., Santos, Á., Arco, A. D., Segovia, G., & Mora, F. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0935-3 · Cited by 63
Cognitive Activation by Central Thalamic Stimulation: The Yerkes-Dodson Law Revisited
Mair, R. G., Onos, K. D., & Hembrook‐Short, J. R. (2010) · Dose-Response · doi:10.2203/dose-response.10-017.mair · Cited by 65
Effects of environmental noise exposure on DNA methylation in the brain and metabolic health
Guo, L., Li, P., Li, H., Colicino, E., Colicino, S., Wen, Y., Zhang, R., Feng, X., Barrow, T. M., Çayır, A., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.11.017 · Cited by 59
Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?
Desbonnet, L., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.001 · Cited by 57
Acute Stress Induces Cognitive Improvement in the Novel Object Recognition Task by Transiently Modulating Bdnf in the Prefrontal Cortex of Male Rats
Brivio, P., Sbrini, G., Riva, M. A., & Calabrese, F. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00793-7 · Cited by 56
The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases
Lam, J., Coleman, N., Garing, A. L. A., & Wulff, H. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.823161 · Cited by 55
A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure
Zakirova, Z., Crynen, G. C., Hassan, S., Abdullah, L. I., Horne, L., Mathura, V. S., Crawford, F., & Ait‐Ghezala, G. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00071 · Cited by 53
Sex differences in chronic stress responses and Alzheimer's disease
Yan, Y., Dominguez, S., Fisher, D. W., & Dong, H. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.03.002 · Cited by 56
Distinct Medial Temporal Lobe Network States as Neural Contexts for Motivated Memory Formation
Murty, V. P., & Adcock, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-50406-3_15 · Cited by 55
Prenatal restraint stress: an in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
Carboni, E., Barros, V. G., Ibba, M., Silvagni, A., Mura, C., & Antonelli, M. C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.046 · Cited by 49
Neuroeconomics of Emotion and Decision Making
Lempert, K. M., & Phelps, E. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416008-8.00012-7 · Cited by 47
Detecting Deceptive Chat-Based Communication Using Typing Behavior and Message Cues
Derrick, D. C., Meservy, T. O., Jenkins, J. L., Burgoon, J. K., & Nunamaker, J. F. (2013) · ACM Transactions on Management Information Systems · doi:10.1145/2499962.2499967 · Cited by 52
Autistic Spectrum Disorders as Functional Disconnection Syndrome
Melillo, R. J., & Leisman, G. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.2.111 · Cited by 46
Effect of chronic stress during adolescence in prefrontal cortex structure and function
Folha, O. A. D. A. C., Bahia, C. P., de Aguiar, G. P. S., Herculano, A. M., Coelho, N. L. G., de Sousa, M. B. C., Shiramizu, V. K. M., Galvão, A. C. D. M., de Carvalho, W. A., & Pereira, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.033 · Cited by 50
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice
Dong, H., Wang, S. D., Zeng, Z., Li, F., Montalvo‐Ortiz, J. L., Tucker, C., Akhtar, S., Shi, J., Meltzer, H. Y., Rice, K. C., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3629-8 · Cited by 45
The Resilience Program: preliminary evaluation of a mentalization-based education program
Bak, P. L., Midgley, N., Zhu, J. L., Wistoft, K., & Obel, C. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00753 · Cited by 39
Psychosocial Syndemic Risks Surrounding Physical Health Conditions Among Sexual and Gender Minority Individuals
Scheer, J. R., & Pachankis, J. E. (2019) · LGBT Health · doi:10.1089/lgbt.2019.0025 · Cited by 40
TIP39 modulates effects of novelty-induced arousal on memory
Coutellier, L. D., Logemann, A., Kuo, J., Rusnák, M., & Usdin, T. B. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00643.x · Cited by 37
Imaging Epigenetics in Alzheimer’s Disease
Lista, S., Garaci, F. G., Toschi, N., & Hampel, H. J. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990370 · Cited by 36
Advancing a functional genomics for schizophrenia: Psychopathological and cognitive phenotypes in mutants with gene disruption
Kirby, B. P., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.010 · Cited by 36
When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression
Freund, N., Thompson, B. S., Sonntag, K., Meda, S., & Andersen, S. L. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4200-y · Cited by 31
D1-dopamine and α1-adrenergic receptors co-localize in dendrites of the rat prefrontal cortex
Mitrano, D. A., Paré, J., Smith, Y., & Weinshenker, D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.002 · Cited by 34
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Zhang, Y.-M., Zong, H.-C., Qi, Y.-B., Chang, L.-L., Gao, Y.-N., Zhou, T., Yin, T., Liu, M., Pan, K.-J., Chen, W.-G., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02283-w · Cited by 27
Modulation of the Mouse Prefrontal Cortex Activation by Neuronal Nicotinic Receptors during Novelty Exploration but not by Exploration of a Familiar Environment
Bourgeois, J., Meas‐Yedid, V., Sourd, A. L., Fauré, P., Pons, S., Maskos, U., Changeux, J., Olivo‐Marín, J., & Granon, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr159 · Cited by 34
Reversal of stress-induced dendritic atrophy in the prefrontal cortex by intracranial self-stimulation
Ramkumar, K., Srikumar, B. N., Venkatasubramanian, D., Siva, R., Rao, B. S. S., & Raju, T. R. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0740-4 · Cited by 26
Primary Cilia–An Underexplored Topic in Major Mental Illness
Pruski, M., & Lang, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00104 · Cited by 25
An unexpected increase in restraint duration alters the expression of stress response habituation
Kearns, R., & Spencer, R. L. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.029 · Cited by 23
Paternal bisphenol a diet changes prefrontal cortex proteome and provokes behavioral dysfunction in male offspring
Luo, G., Wei, R., Wang, S., & Wang, J. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.06.050 · Cited by 23
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg, E., Horschitz, S., Schloss, P., & Meyer-Lindenberg, A. (2018) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.04.017 · Cited by 17
Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons
Szulczyk, B., & Nurowska, E. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.109 · Cited by 19
The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction
Kermath, B. A., Vanderplow, A. M., Bjornson, K. J., Seablom, E. N., Novak, A., Bernhardt, C. R., & Cahill, M. E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0835-0 · Cited by 17
Neurochemical and behavioral effects of chronic unpredictable stress
Matuszewich, L., McFadden, L. M., Friedman, R. D., & Frye, C. A. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000061 · Cited by 18
Acute stress enhances learning and memory by activating acid-sensing ion channels in rats
Ye, S., Yang, R., Xiong, Q., Yang, Y., Zhou, L., Gong, Y., Li, C., Ding, Z., Ye, G., & Xiong, Z. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.122 · Cited by 18
The Unique Properties of the Prefrontal Cortex and Mental Illness
Gao, W., Wang, H.-X., Melissa, A., & Li, Y. (2012) · InTech eBooks · doi:10.5772/35868 · Cited by 17
Effect of cyclic adenosine monophosphate on the G protein-dependent inward rectifier K(+)-like channel current in medial prefrontal cortex pyramidal neurons.
Witkowski, G., Rola, R., & Szulczyk, P. J. (2012) · PubMed · Cited by 18
Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
Gatta, E., Saudagar, V., Auta, J., Grayson, D. R., & Guidotti, A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.08.002 · Cited by 19
Genome-wide methylome-based molecular pathologies associated with depression and suicide
Dwivedi, Y., Roy, B., & Korla, P. K. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02040-9 · Cited by 16
Suicide: Allostatic regulation and resilience
Stacy, M. A., & Schulkin, J. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105691 · Cited by 16
Adolescent Stress Confers Resilience to Traumatic Stress Later in Life: Role of the Prefrontal Cortex
Cotella, E. M., Nawreen, N., Moloney, R. D., Martelle, S. E., Oshima, K. M., Lemen, P. M., NiBlack, J. N., Julakanti, R. R., Fitzgerald, M. E., Baccei, M. L., et al. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.02.009 · Cited by 15
Noise induced epigenetic effects: A systematic review.
Leso, V., Fontana, L., Finiello, F., Cicco, L. D., Ercolano, M. L., & Iavicoli, I. (2020) · PubMed Central · doi:10.4103/nah.nah_17_20 · Cited by 15
Activation of the anti‐inflammatory reflex blocks lipopolysaccharide‐induced decrease in synaptic inhibition in the temporal cortex of the rat
García‐Oscos, F., Peña, D. F., Housini, M., Cheng, D., Lopez, D. A., Cuevas‐Olguin, R., Saderi, N., Delgado, R. S., Galindo‐Charles, L., Salgado, H., et al. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23550 · Cited by 12
Effects of Acute Exercise on Cognitive Flexibility in Young Adults with Different Levels of Aerobic Fitness
Shi, B., Mou, H., Tian, S., Meng, F., & Qiu, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159106 · Cited by 14
Modeling schizophrenia in flies
Furukubo-Tokunaga, K. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17912-8 · Cited by 12
Inward rectifier K+ channel and T-type Ca2+ channel contribute to enhancement of GABAergic transmission induced by β1-adrenoceptor in the prefrontal cortex
Luo, F., Zheng, J., Sun, X., & Tang, H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.11.007 · Cited by 11
Mediodorsal thalamic lesions block the stress-induced inversion of serial memory retrieval pattern in mice
Chauveau, F., Piérard, C., Corio, M., Célérier, A., Tronche, C., Vouimba, R. M., Guillou, J., & Béracochéa, D. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.014 · Cited by 11
Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats
Daniels, S., Mansari, M. E., Hamoudeh, R. A., & Blier, P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1276309 · Cited by 11
Prefrontal Catecholaminergic Turnover and Antioxidant Defense System of Chronically Stressed Rats
Popović, N., Pajović, S. B., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., & Gavrilović, L. (2017) · Folia Biologica · doi:10.3409/fb65_1.43 · Cited by 10
Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers
Smith, E. L., Brown, A. S., Adjaye-Mensah, E., & Wilson, J. N. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob06796j · Cited by 10
β-Adrenergic receptor agonist increases voltage-gated Na+ currents in medial prefrontal cortex pyramidal neurons
Szulczyk, B. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.015 · Cited by 9
Neuroscience: Rethinking rehab
Schnabel, J. (2009) · Nature · doi:10.1038/458025a · Cited by 9
Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function
Bjornson, K. J., Vanderplow, A. M., Yang, Y., Anderson, D. R., Kermath, B. A., & Cahill, M. E. (2023) · iScience · doi:10.1016/j.isci.2023.107566 · Cited by 9
α1b-Adrenergic Receptor Localization and Relationship to the D1-Dopamine Receptor in the Rat Nucleus Accumbens
Mitrano, D. A., Jackson, K., Finley-May, S., & Seeley, A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.053 · Cited by 8
Dissociating and linking divergent effects of emotion on cognition: insights from current research and emerging directions
Dolcos, F., Denkova, E., Iordan, A. D., Shafer, A. T., Fernández, G., & Dolcos, S. M. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1483373 · Cited by 11
The Neurobiology of Posttraumatic Stress
Johnson, S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374851-5.00002-0 · Cited by 7
Changes in Prefrontal Gamma-Aminobutyric Acid and Perfusion After the Computerized Relaxation Training in Women With Psychological Distress: A Preliminary Report
Namgung, E., Kim, J., Jeong, H. S., Ma, J., Hong, G., Kang, I., Kim, J., Joo, Y., Kim, R. Y., & Lyoo, I. K. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.569113 · Cited by 7
Negative affectivity drivers of impulsivity in opioid use disorder
Vassileva, J., Psederska, E., & Bjork, J. M. (2025) · Nature Reviews Psychology · doi:10.1038/s44159-025-00404-6 · Cited by 6
Altered expression and alpha‐1 adrenergic receptor mediated activity of protein kinase C in the prefrontal cortex of rats with neonatal ventral hippocampus lesions
Al‐Khairi, I., Baharnoori, M., Kamath, A., Bhardwaj, S. K., & Srivastava, L. K. (2009) · Synapse · doi:10.1002/syn.20691 · Cited by 5
Dissocier les effets facilitants et les effets délétères de l’émotion sur la cognition
Dolcos, F., & Denkova, E. (2016) · Santé mentale au Québec · doi:10.7202/1036964ar · Cited by 9
Dissociating Enhancing and Impairing Effects of Emotion on Cognition
Dolcos, F., & Denkova, E. (2015) · Emerging Trends in the Social and Behavioral Sciences · doi:10.1002/9781118900772.etrds0079 · Cited by 5

Authors: Hains, A. B., & Arnsten, A. F. T.
Affiliations: Yale University (US)
ORCID: Arnsten, Amy F.T.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2008-08
Volume: 15
Issue: 8
Pages: 551-564
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.921708
OpenAlex: W2137006544
Cited by: 127
References: 261
Citations by year: 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 10
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (U54RR024350)
National Institute on Alcohol Abuse and Alcoholism (RL1AA017536)
National Institute of Mental Health (P50MH068789)
National Center for Research Resources (U54RR024350-01)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: prefrontal cortex, stress, mental illness, dopamine D1 receptor, cAMP signaling, DISC1, RGS4, diacylglycerol kinase, bipolar disorder, schizophrenia, genetic susceptibility, working memory, disinhibition, thought disorder, stress-induced cognitive impairment
MeSH terms: Animals, Mental Disorders, Humans, Stress, Physiological, Signal Transduction, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks