Stress-Related Methylation of the Catechol- O -Methyltransferase Val 158 Allele Predicts Human Prefrontal Cognition and Activity
Open accessAbstract
DNA methylation at CpG dinucleotides is associated with gene silencing, stress, and memory. The catechol-O-methyltransferase (COMT) Val(158) allele in rs4680 is associated with differential enzyme activity, stress responsivity, and prefrontal activity during working memory (WM), and it creates a CpG dinucleotide. We report that methylation of the Val(158) allele measured from peripheral blood mononuclear cells (PBMCs) of Val/Val humans is associated negatively with lifetime stress and positively with WM performance; it interacts with stress to modulate prefrontal activity during WM, such that greater stress and lower methylation are related to reduced cortical efficiency; and it is inversely related to mRNA expression and protein levels, potentially explaining the in vivo effects. Finally, methylation of COMT in prefrontal cortex and that in PBMCs of rats are correlated. The relationship of methylation of the COMT Val(158) allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity. Moreover, these results demonstrate how stress-related DNA methylation of specific functional alleles impacts directly on human brain physiology beyond sequence variation.
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In rats, a direct correlation between catechol-O-methyltransferase (COMT) methylation in peripheral mononuclear blood cells and the prefrontal cortex was observed.
“In rats, a direct correlation between catechol-O-methyltransferase (COMT) methylation in peripheral mononuclear blood cells and the prefrontal cortex was observed (Ursini et al., 2011).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Ursini et al., 2011
Several studies indicate a role of the COMT gene in stress reactivity on a genetic and epigenetic level.
“as several studies indicate its role in stress reactivity on a genetic [46,47] and epigenetic level [48].”
From Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation (2021) · cites this paper as [48]
For COMT DNAm, several studies show that methylation status in peripheral tissue can serve as a surrogate for brain DNAm.
“Indeed, for COMT DNAm several studies show that methylation status in peripheral tissue can serve as surrogate for brain DNAm [48,50].”
From Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation (2021) · cites this paper as [48]
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works
Neuroimaging studies of working memory:
Wager, T. D., & Smith, E. E. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.4.255 · Cited by 1,889 · see citing works
Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation
Zemach, A., McDaniel, I. E., Silva, P., & Zilberman, D. (2010) · Science · doi:10.1126/science.1186366 · Cited by 1,796 · see citing works
Conserved role of intragenic DNA methylation in regulating alternative promoters
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743 · see citing works
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675 · see citing works
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409 · see citing works
Covalent Modification of DNA Regulates Memory Formation
Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,180 · see citing works
Lotta, T. I., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995) · Biochemistry · doi:10.1021/bi00013a008 · Cited by 1,167 · see citing works
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works
Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works
Nackley, A. G., Shabalina, S. A., Tchivileva, I. E., Satterfield, K., Korchynskyi, O., Makarov, S. S., Maixner, W., & Diatchenko, L. (2006) · Science · doi:10.1126/science.1131262 · Cited by 848 · cited 1× · see citing works
“This interpretation is also consistent with previous findings indicating that Val behaves as a high-activity allele when found on a high genetic expression background, but not otherwise (MeyerLindenberg et al., 2006; Nackley et al., 2006).”
ResultDNA methylation analysis by pyrosequencing
Tost, J., & Gut, I. G. (2007) · Nature Protocols · doi:10.1038/nprot.2007.314 · Cited by 665 · see citing works
Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene
Bollati, V., Baccarelli, A., Hou, L., Bonzini, M., Fustinoni, S., Cavallo, D. M., Byun, H., Jiang, J., Marinelli, B., Pesatori, A. C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2995 · Cited by 612 · see citing works
Self-citationSesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
The social environment and the epigenome
Moshe Szyf, A., McGowan, P. O., & Meaney, M. J. (2007) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20357 · Cited by 533 · see citing works
Cortical DNA methylation maintains remote memory
Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., & Sweatt, J. D. (2010) · Nature Neuroscience · doi:10.1038/nn.2560 · Cited by 521 · see citing works
DNA Methylation Analysis by Pyrosequencing
Busato, F., & Tost, J. (2014) · Springer eBooks · doi:10.1007/978-1-4614-6418-1_799-1 · Cited by 500 · see citing works
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464 · see citing works
Smolka, M. N., Schumann, G., Wrase, J., Grüsser, S. M., Flor, H., Mann, K. F., Braus, D. F., Goldman, D. A., Büchel, C., & Heinz, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1792-04.2005 · Cited by 416 · see citing works
Holliday, R., & Grigg, G. W. (1993) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(93)90052-h · Cited by 345 · see citing works
Impact of complex genetic variation in COMT on human brain function
Meyer‐Lindenberg, A., Nichols, T. E., Callicott, J. H., Ding, J., Kolachana, B. S., Buckholtz, J. W., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001860 · Cited by 321 · see citing works
A longitudinal study of epigenetic variation in twins
Wong, C. C. Y., Caspi, A., Williams, B. S., Craig, I., Houts, R., Ambler, A. P., Moffitt, T. E., & Mill, J. S. (2010) · Epigenetics · doi:10.4161/epi.5.6.12226 · Cited by 320 · see citing works
The role of stress in the pathophysiology of the dopaminergic system
Pani, L., Porcella, A., & Gessa, G. L. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000589 · Cited by 314 · see citing works
Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R., & Chen, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2077-08.2008 · Cited by 288 · see citing works
Bertolino, A., Caforio, G., Blasi, G., Candia, M. D., Latorre, V., Petruzzella, V., Altamura, M., Nappi, G., Papa, S., Callicott, J. H., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1798 · Cited by 287 · see citing works
Self-citationKolassa, I., Kolassa, S., Ertl, V., Papassotiropoulos, A., & de Quervain, D. J. ‐. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.009 · Cited by 245 · see citing works
Gene–gene interaction associated with neural reward sensitivity
Yacubian, J., Sommer, T., Schroeder, K., Gläscher, J., Kalisch, R., Leuenberger, B., Braus, D. F., & Büchel, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702029104 · Cited by 241 · see citing works
Krugel, L. K., Biele, G., Mohr, P. N. C., Li, S.-C., & Heekeren, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905191106 · Cited by 229 · see citing works
Epigenetic regulation of the neural transcriptome: the meaning of the marks
Meaney, M. J., & Ferguson-Smith, A. C. (2010) · Nature Neuroscience · doi:10.1038/nn1110-1313 · Cited by 216 · see citing works
Aryl hydrocarbon receptor activation by cAMP vs. dioxin: Divergent signaling pathways
Oesch‐Bartlomowicz, B., Huelster, A., Wiss, O., Antoniou‐Lipfert, P., Dietrich, C., Arand, M., Weiß, C., Bockamp, E., & Oesch, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503488102 · Cited by 185 · see citing works
Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype
Bertolino, A., Rubino, V., Sambataro, F., Blasi, G., Latorre, V., Fazio, L., Caforio, G., Petruzzella, V., Kolachana, B. S., Hariri, A. R., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.078 · Cited by 171 · see citing works
Self-citationTan, H.-Y., Chen, Q., Goldberg, T. E., Mattay, V. S., Meyer-Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4041-07.2007 · Cited by 144 · see citing works
Habeck, C. G., Rakitin, B. C., Moeller, J. R., Scarmeas, N., Zarahn, E., Brown, T. R., & Stern, Y. (2004) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2004.10.010 · Cited by 135 · see citing works
Mill, J. S., Dempster, E. L., Caspi, A., Williams, B. S., Moffitt, T. E., & Craig, I. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30316 · Cited by 134 · see citing works
Schnekenburger, M., Li, P., & Puga, A. (2007) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2007.07.002 · Cited by 133 · see citing works
Matsumoto, M., Weickert, C. S., Beltaifa, S., Kolachana, B. S., Chen, J., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300218 · Cited by 133 · see citing works
Dempster, E. L., Mill, J., Craig, I. W., & Collier, D. A. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-10 · Cited by 129 · see citing works
Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.921708 · Cited by 127 · see citing works
Bertolino, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.10.1798 · Cited by 118 · see citing works
Self-citationvan Winkel, R., Henquet, C., Rosa, A., Papiol, S., Fañanás, L., Binder, M. D., Peuskens, J., van Os, J., & Myin‐Germeys, I. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30559 · Cited by 112 · see citing works
Murphy, B. C., O'Reilly, R. L., & Singh, S. M. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30134 · Cited by 102 · see citing works
Bertolino, A., Taurisano, P., Pisciotta, N. M., Blasi, G., Fazio, L., Romano, R., Gelao, B., Bianco, L. L., Lozupone, M., Giorgio, A. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009348 · Cited by 97 · see citing works
Self-citationSartor, M. A., Schnekenburger, M., Marlowe, J. L., Reichard, J. F., Wang, Y., Fan, Y., Ma, C., Karyala, S. V., Halbleib, D., Liu, X., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800485 · Cited by 96 · see citing works
McNeil, T. F., Cantor‐Graae, E., Torrey, E. F., Sjöström, K., Bowler, A., Taylor, E., Rawlings, R. R., & Higgins, E. S. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb08092.x · Cited by 90 · see citing works
Verdoux, H., Sutter, A. L., Glatigny-Dallay, É., & Minisini, A. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.02398.x · Cited by 76 · see citing works
Maternal recall bias, obstetric history and schizophrenia
McIntosh, A. M., Holmes, S., Gleeson, S., Burns, J. K., Hodges, A., Byrne, M., Dobbie, R., Miller, P. M., Lawrie, S. M., & Johnstone, E. C. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.6.520 · Cited by 54 · see citing works
Risk for obstetric complications and schizophrenia
Preti, A., Cardascia, L., Zen, T., Marchetti, M., Favaretto, G., & Miotto, P. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00185-2 · Cited by 53 · see citing works
Desaulniers, D., Xiao, G.-H., Leingartner, K., Chu, I., Musicki, B., & Tsang, B. K. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi178 · Cited by 50 · see citing works
Li, Z., Mulligan, M. K., Wang, X., Miles, M. F., Lu, L., & Williams, R. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012181 · Cited by 49 · see citing works
Seifert, A. M., Demers, C., Dubeau, H., & Messing, K. (1993) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(93)90031-8 · Cited by 45 · see citing works
Gearhart, D. A., Middlemore, M.-L., & Terry, A. V. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.06.009 · Cited by 44 · see citing works
Gao, M. C., Bellugi, U., Dai, L., Mills, D. L., Sobel, E. M., Lange, K., & Korenberg, J. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010292 · Cited by 42 · see citing works
Walder, D. J., Trotman, H. D., Cubells, J. F., Brasfield, J., Tang, Y.-L., & Walker, E. F. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a1ff3 · Cited by 34 · see citing works
Castri, P., Iacovelli, L., Blasi, A. D., Giubilei, F., Moretti, A., Capone, F. T., Nicoletti, F., & Orzi, F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05869.x · Cited by 24 · see citing works
Self-citationArnsten, A. F. T., & Goldman-Rakic, P. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.4.362 · Cited by 6 · see citing works
Flagged first, then by citations
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Burnside, R. D. (2015) · Cytogenetic and Genome Research · doi:10.1159/000438708 · Cited by 1,958 · see citing works
The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia
Howes, O. D., McCutcheon, R. A., Owen, M. J., & Murray, R. M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.014 · Cited by 604 · see citing works
The role of DNA methylation in stress-related psychiatric disorders
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works
Convergence of placenta biology and genetic risk for schizophrenia
Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., Hamilton, E. G., Mitjans, M., Maddalena, G., Begemann, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0021-y · Cited by 266 · see citing works
Self-citationNeural substrates of early executive function development
Fiske, A., & Holmboe, K. (2019) · Developmental Review · doi:10.1016/j.dr.2019.100866 · Cited by 264 · see citing works
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders
Schiele, M. A., & Domschke, K. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12423 · Cited by 233 · see citing works
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 226 · see citing works
Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety
Ziegler, C., Dannlowski, U., Bräuer, D., Stevens, S., Laeger, I., Wittmann, H., Kugel, H., Dobel, C., Hurlemann, R., Reif, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.2 · Cited by 193 · see citing works
Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response
Domschke, K., Tidow, N., Schwarte, K., Deckert, J., Lesch, K., Arolt, V., Zwanzger, P., & Baune, B. T. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571400039x · Cited by 179 · see citing works
Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder
Dresler, T., Guhn, A., Tupak, S. V., Ehlis, A., Herrmann, M. J., Fallgatter, A. J., Deckert, J., & Domschke, K. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0811-1 · Cited by 177 · see citing works
Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential
Bogdan, R., Salmeron, B. J., Carey, C. E., Arpana Agrawal, A., Calhoun, V. D., Garavan, H., Hariri, A. R., Heinz, A., Hill, M. N., Holmes, A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.030 · Cited by 167 · see citing works
Epigenetic programming by stress and glucocorticoids along the human lifespan
Zannas, A. S., & Chrousos, G. P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.35 · Cited by 158 · see citing works
Schiele, M. A., Gottschalk, M. G., & Domschke, K. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101830 · Cited by 156 · see citing works
Gaysina, D., Fergusson, D. M., Leve, L. D., Horwood, J., Reiss, D., Shaw, D. S., Elam, K. K., Natsuaki, M. N., Neiderhiser, J. M., & Harold, G. T. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.127 · Cited by 152 · see citing works
The neurobiological correlates of childhood adversity and implications for treatment
Tyrka, A. R., Burgers, D. E., Philip, N. S., Price, L. H., & Carpenter, L. L. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12143 · Cited by 142 · see citing works
Farrell, S., Tunbridge, E. M., Braeutigam, S., & Harrison, P. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.023 · Cited by 144 · see citing works
Plewnia, C., Zwissler, B., Längst, I., Maurer, B., Giel, K. E., & Krüger, R. (2012) · Cortex · doi:10.1016/j.cortex.2012.11.002 · Cited by 134 · see citing works
Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”
Bakulski, K. M., Halladay, A., Hu, V. W., Mill, J., & Fallin, M. D. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0083-4 · Cited by 127 · see citing works
Scarr, E., Millan, M. J., Bahn, S., Bertolino, A., Turck, C. W., Kapur, S., Möller, H., & Dean, B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv042 · Cited by 135 · see citing works
Self-citationDuman, E. A., & Canli, T. (2015) · Biology of Mood & Anxiety Disorders · doi:10.1186/s13587-015-0017-x · Cited by 128 · see citing works
Shumay, E., Logan, J., Volkow, N. D., & Fowler, J. S. (2012) · Epigenetics · doi:10.4161/epi.21976 · Cited by 120 · see citing works
Predicting DNA methylation level across human tissues
Ma, B., Wilker, E. H., Willis‐Owen, S. A. G., Byun, H., Wong, K., Motta, V., Baccarelli, A., Schwartz, J. D., Cookson, W., Khabbaz, K. R., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1380 · Cited by 115 · see citing works
Self-citationEpigenetic epidemiology: Promises for public health research
Bakulski, K. M., & Fallin, M. D. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21850 · Cited by 112 · see citing works
Antypa, N., Drago, A., & Serretti, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.006 · Cited by 111 · see citing works
Neurogenetics of depression: A focus on reward processing and stress sensitivity
Bogdan, R., Nikolova, Y. S., & Pizzagalli, D. A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.007 · Cited by 105 · see citing works
Norrholm, S. D., Jovanovic, T., Smith, A. K., Binder, E., Klengel, T., Conneely, K., Mercer, K. B., Davis, J. S., Kerley, K., Winkler, J., et al. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00030 · Cited by 104 · see citing works
Understanding risk for psychopathology through imaging gene–environment interactions
Hyde, L. W., Bogdan, R., & Hariri, A. R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.001 · Cited by 102 · see citing works
Beyond the genome—Towards an epigenetic understanding of handedness ontogenesis
Schmitz, J., Metz, G. A. S., Güntürkün, O., & Ocklenburg, S. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.005 · Cited by 97 · see citing works
Trantham‐Davidson, H., Centanni, S. W., Garr, S. C., New, N., Mulholland, P. J., Gass, J. T., Glover, E. J., Floresco, S., Crews, F. T., Krishnan, H. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.190 · Cited by 100 · see citing works
Burris, H. H., Braun, J. M., Byun, H., Tarantini, L., Mercado, A., Wright, R. J., Schnaas, L., Baccarelli, A., Wright, R. O., & Téllez‐Rojo, M. M. (2013) · Epigenomics · doi:10.2217/epi.13.24 · Cited by 96 · see citing works
Self-citationRoth, T. L. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000618 · Cited by 95 · see citing works
Epigenetics, Development, and Psychopathology
O'Donnell, K. J., & Meaney, M. J. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095530 · Cited by 94 · see citing works
Domschke, K., Tidow, N., Schrempf, M., Schwarte, K., Klauke, B., Reif, A., Kersting, A., Arolt, V., Zwanzger, P., & Deckert, J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.07.014 · Cited by 87 · see citing works
Frodl, T., Szyf, M., Carballedo, A., Ly, V., Dymov, S., Vaisheva, F., Morris, D., Fahey, C., Meaney, J., Gill, M., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140180 · Cited by 86 · see citing works
DNA methylation and brain structure and function across the life course: A systematic review
Wheater, E., Stoye, D. Q., Cox, S. R., Wardlaw, J. M., Drake, A. J., Bastin, M. E., & Boardman, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.007 · Cited by 82 · see citing works
Bogdan, R., Hyde, L. W., & Hariri, A. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.35 · Cited by 82 · see citing works
Pieramico, V., Esposito, R., Sensi, F., Cilli, F., Mantini, D., Mattei, P. A., Frazzini, V., Ciavardelli, D., Gatta, V., Ferretti, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043901 · Cited by 80 · see citing works
Wyns, A., Hendrix, J., Lahousse, A., Bruyne, E. D., Nijs, J., Godderis, L., & Polli, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062245 · Cited by 84 · see citing works
Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes
Nagy, C., & Turecki, G. (2012) · Epigenomics · doi:10.2217/epi.12.37 · Cited by 78 · see citing works
Epigenetic pathways through which experiences become linked with biology
McGowan, P. O., & Roth, T. L. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000206 · Cited by 72 · see citing works
The future of fMRI and genetics research
Meyer‐Lindenberg, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.063 · Cited by 72 · see citing works
Chen, J., Zang, Z., Braun, U., Schwarz, K., Harneit, A., Kremer, T., Ma, R., Schweiger, J., Moessnang, C., Geiger, L., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4792 · Cited by 69 · see citing works
Can we observe epigenetic effects on human brain function?
Nikolova, Y. S., & Hariri, A. R. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.003 · Cited by 67 · see citing works
Catechol-O-methyltransferase gene variation: Impact on amygdala response to aversive stimuli
Domschke, K., Baune, B. T., Havlik, L., Stuhrmann, A., Suslow, T., Kugel, H., Zwanzger, P., Grotegerd, D., Sehlmeyer, C., Arolt, V., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.039 · Cited by 67 · see citing works
Bevilacqua, L. M., & Goldman, D. A. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.009 · Cited by 67 · see citing works
Biological Effects of COMT Haplotypes and Psychosis Risk in 22q11.2 Deletion Syndrome
Gothelf, D., Law, A. J., Frisch, A., Chen, J., Zarchi, O., Michaelovsky, E., Ren‐Patterson, R. F., Lipska, B. K., Carmel, M., Kolachana, B. S., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.021 · Cited by 66 · see citing works
COMTVal158Met genotype is associated with reward learning: a replication study and meta‐analysis
Corral-Frías, N. S., Pizzagalli, D. A., Carré, J. M., Michalski, L. J., Nikolova, Y. S., Perlis, R. H., Fagerness, J. A., Lee, M. R., Drabant, E. M., Lancaster, T. M., et al. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12296 · Cited by 65 · see citing works
Walton, E., Liu, J.-Y., Hass, J., White, T., Scholz, M., Roessner, V., Gollub, R., Calhoun, V., & Ehrlich, S. (2014) · Epigenetics · doi:10.4161/epi.29223 · Cited by 66 · see citing works
Humphreys, K. L., Moore, S. R., Davis, E., MacIsaac, J. L., Lin, D. T. S., Kobor, M. S., & Gotlib, I. H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0582-7 · Cited by 67 · see citing works
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system
SIROHI, S. K., Bakalkin, G. Y., & Walker, B. M. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00095 · Cited by 64 · see citing works
BDNF rs6265 methylation and genotype interact on risk for schizophrenia
Ursini, G., Cavalleri, T., Fazio, L., Angrisano, T., Iacovelli, L., Porcelli, A., Maddalena, G., Punzi, G., Mancini, M., Gelao, B., et al. (2016) · Epigenetics · doi:10.1080/15592294.2015.1117736 · Cited by 62 · see citing works
Self-citationBastos, P., Gomes, T. M. B., & Ribeiro, L. V. P. T. (2017) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2017_2 · Cited by 62 · see citing works
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter, A. B., Daughters, S. B., MacPherson, L., Reynolds, E. K., Danielson, C. K., Wang, F. M., Potenza, M. N., Gelernter, J. E., & Lejuez, C. W. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.017 · Cited by 60 · see citing works
Age modulates the effect of COMT genotype on delay discounting behavior
Smith, C. T., & Boettiger, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2653-9 · Cited by 59 · see citing works
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time
Forest, M., O’Donnell, K. J., Voisin, G., Gaudreau, H., MacIsaac, J. L., McEwen, L. M., Silveira, P. P., Steiner, M. S., Kobor, M. S., Meaney, M. J., et al. (2018) · Epigenetics · doi:10.1080/15592294.2017.1411443 · Cited by 59 · see citing works
Effects of environmental noise exposure on DNA methylation in the brain and metabolic health
Guo, L., Li, P., Li, H., Colicino, E., Colicino, S., Wen, Y., Zhang, R., Feng, X., Barrow, T. M., Çayır, A., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.11.017 · Cited by 58 · see citing works
Self-citationMaternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD
O’Donnell, K. J., Glover, V. A. S., Lahti, J. M. T., Lahti‐Pulkkinen, M., Edgar, R. D., Räikkönen, K., & O’Connor, T. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177506 · Cited by 57 · see citing works
Sex Differences in COMT Polymorphism Effects on Prefrontal Inhibitory Control in Adolescence
White, T. P., Loth, E., Rubia, K., A, L. K. M., Whelan, R., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.107 · Cited by 57 · see citing works
He, Q., Xue, G., Chen, C., Lu, Z., Chen, C., Lei, X., Liu, Y., Li, J., Zhu, B., Moyzis, R. K., et al. (2012) · Scientific Reports · doi:10.1038/srep00677 · Cited by 55 · see citing works
CRHR1 promoter hypomethylation: An epigenetic readout of panic disorder?
Schartner, C., Ziegler, C., Schiele, M. A., Kollert, L., Weber, H., Zwanzger, P., Arolt, V., Pauli, P., Deckert, J., Reif, A., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.01.005 · Cited by 53 · see citing works
Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response
Domschke, K., Tidow, N., Schwarte, K., Ziegler, C., Lesch, K., Deckert, J., Arolt, V., Zwanzger, P., & Baune, B. T. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1227-x · Cited by 52 · see citing works
COMT as a Drug Target for Cognitive Functions and Dysfunctions
Scheggia, D., Sannino, S., Scattoni, M. L., & Papaleo, F. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800672481 · Cited by 52 · see citing works
Neuroimaging genomics in psychiatry—a translational approach
Mufford, M. S., Stein, D. J., Dalvie, S., Groenewold, N. A., Thompson, P. M., & Jahanshad, N. (2017) · Genome Medicine · doi:10.1186/s13073-017-0496-z · Cited by 51 · see citing works
Na, K.-S., Won, E., Kang, J., Kim, A., Choi, S., Tae, W.-S., Kim, Y.-K., Lee, M.-S., Joe, S.-H., & Ham, B.-J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.030 · Cited by 50 · see citing works
Schiele, M. A., Zwanzger, P., Schwarte, K., Arolt, V., Baune, B. T., & Domschke, K. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa081 · Cited by 47 · see citing works
DNA Methylation in Schizophrenia Subjects: Gender and <i>MTHFR</i> 677C/T Genotype Differences
Burghardt, K. J., Pilsner, J. R., Bly, M. J., & Ellingrod, V. L. (2012) · Epigenomics · doi:10.2217/epi.12.25 · Cited by 49 · see citing works
Genetic Moderation of Stress Effects on Corticolimbic Circuitry
Bogdan, R., Pagliaccio, D., Baranger, D. A. A., & Hariri, A. R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.216 · Cited by 48 · see citing works
Lott, S. A., Burghardt, P. R., Burghardt, K. J., Bly, M. J., Grove, T. B., & Ellingrod, V. L. (2012) · The Pharmacogenomics Journal · doi:10.1038/tpj.2012.6 · Cited by 48 · see citing works
Wiers, C. E., Lohoff, F. W., Lee, J., Muench, C., Freeman, C. R., Zehra, A., Marenco, S., Lipska, B. K., Auluck, P. K., Feng, N., et al. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14067 · Cited by 48 · see citing works
Ciuculete, D. M., Boström, A. E., Voisin, S., Philipps, H., Titova, O. E., Bandstein, M., Nikontovic, L., Williams, M. J., Mwinyi, J., & Schiöth, H. B. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.275 · Cited by 40 · see citing works
The DNA methylome in panic disorder: A case-control and longitudinal psychotherapy-epigenetic study
Ziegler, C., Grundner-Culemann, F., Schiele, M. A., Schlosser, P., Kollert, L., Mahr, M., Gajewska, A., Lesch, K.-P., Deckert, J., Köttgen, A., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0648-6 · Cited by 47 · see citing works
Placental genomic risk scores and early neurodevelopmental outcomes
Ursini, G., Punzi, G., Langworthy, B., Chen, Q., Xia, K., Cornea, E. A., Goldman, B. D., Styner, M. A., Knickmeyer, R. C., Gilmore, J. H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019789118 · Cited by 45 · see citing works
Self-citationCannabis controversies: how genetics can inform the study of comorbidity
Arpana Agrawal, A., & Lynskey, M. T. (2014) · Addiction · doi:10.1111/add.12436 · Cited by 45 · see citing works
Hyde, L. W. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000188 · Cited by 45 · see citing works
Boecker-Schlier, R., Holz, N. E., Buchmann, A. F., Blomeyer, D., Plichta, M. M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.006 · Cited by 42 · see citing works
Hernaus, D., Collip, D., Lataster, J., Ceccarini, J., Kenis, G., Booij, L., Pruessner, J. C., Laere, K. V., van Winkel, R., van Os, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065662 · Cited by 41 · see citing works
Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice
Desbonnet, L., Tighe, O., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & O’Tuathaigh, C. M. P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.014 · Cited by 38 · see citing works
Genetic Factors in Anxiety Disorders
Domschke, K., & Maron, E. (2013) · Modern trends in psychiatry · doi:10.1159/000351932 · Cited by 39 · see citing works
Swift‐Scanlan, T., Smith, C. T., Bardowell, S. A., & Boettiger, C. A. (2014) · BMC Medical Genomics · doi:10.1186/1755-8794-7-5 · Cited by 37 · see citing works
Imaging epigenetics in Alzheimer's disease.
Lista, S., Garaci, F., Toschi, N., & Hampel, H. (2013) · Current pharmaceutical design · doi:10.2174/13816128113199990370 · Cited by 37 · see citing works
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 34 · see citing works
Merrill, S. M., Gladish, N., Fu, M. P., Moore, S. R., Konwar, C., Giesbrecht, G. F., MacIssac, J. L., Kobor, M. S., & Letourneau, N. L. (2021) · Attachment & Human Development · doi:10.1080/14616734.2021.1938872 · Cited by 33 · see citing works
Diwadkar, V. A., Bustamante, A. C., Rai, H., & Uddin, M. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00071 · Cited by 29 · see citing works
Sarginson, J. E., Deakin, J. F. W., Anderson, I. M., Downey, D., Thomas, E., Elliott, R., & Juhász, G. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.137 · Cited by 29 · see citing works
Du, L., Merali, Z., Poulter, M. O., Palkovits, M., Faludi, G., & Anisman, H. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.016 · Cited by 28 · see citing works
Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender
Klein, M., Schmoeger, M., Kasper, S. F., & Schosser, A. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1083615 · Cited by 27 · see citing works
Carli, M. M. D., Baccarelli, A., Trevisi, L., Pantic, I., Brennan, K. J. M., Hacker, M. R., Loudon, H., Brunst, K. J., Wright, R. O., Wright, R. J., et al. (2017) · Epigenomics · doi:10.2217/epi-2016-0109 · Cited by 27 · see citing works
Self-citationNeuroepigenetics of Schizophrenia
Punzi, G., Bharadwaj, R. A., & Ursini, G. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.010 · Cited by 26 · see citing works
Self-citationVidrascu, E. M., Bashore, A. C., Howard, T. D., & Moore, J. B. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0764-4 · Cited by 27 · see citing works
Mallick, R., & Duttaroy, A. K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105627 · Cited by 26 · see citing works
Wei, J., Cheng, J., Waddell, N. J., Wang, Z.-J., Pang, X., Cao, Q., Liu, A., Chitaman, J. M., Abreu, K., Jasrotia, R. S., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa337 · Cited by 26 · see citing works
Association between COMT methylation and response to treatment in children with ADHD
Fageera, W., Chaumette, B., Fortier, M., Grizenko, N., Labbe, A., Sengupta, S. M., & Joober, R. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.01.008 · Cited by 23 · see citing works
Reed, J. L., D'Ambrosio, E., Marenco, S., Ursini, G., Zheutlin, A. B., Blasi, G., Spencer, B. E., Romano, R., Hochheiser, J., Reifman, A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195189 · Cited by 17 · see citing works
Self-citationLewis, C. R., Henderson-Smith, A., Breitenstein, R. S., Sowards, H., Piras, I. S., Huentelman, M. J., Doane, L. D., & Lemery‐Chalfant, K. (2019) · Epigenetics · doi:10.1080/15592294.2019.1583032 · Cited by 22 · see citing works
Epigenetics and the developmental origins of vulnerability for mental disorders
Meaney, M. J., & O’Donnell, K. J. (2015) · Wiley eBooks · doi:10.1002/9781118381953.ch25 · Cited by 23 · see citing works
Pap, D., Gonda, X., Molnár, E., Lazáry, J., Benkő, A., Downey, D., Thomas, E., Chase, D. S., Toth, Z. G., Mekli, K., et al. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32098 · Cited by 21 · see citing works
Neuroimaging Epigenetics: Challenges and Recommendations for Best Practices
Lancaster, K., Morris, J. P., & Connelly, J. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.004 · Cited by 21 · see citing works
Methylation and the human brain: towards a new discipline of imaging epigenetics
Wiers, C. E. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0261-z · Cited by 21 · see citing works
Wiegand, A., Blickle, A., Brückmann, C., Weller, S., Nieratschker, V., & Plewnia, C. (2021) · Biomolecules · doi:10.3390/biom11111726 · Cited by 19 · see citing works
Gaysina, D., Xu, M. K., Barnett, J. H., Croudace, T. J., Wong, A., Richards, M., & Jones, P. B. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.11.007 · Cited by 20 · see citing works
- Authors
- Ursini, G., Bollati, V., Fazio, L., Porcelli, A., Iacovelli, L., Catalani, A., Sinibaldi, L., Gelao, B., Romano, R., Rampino, A., Taurisano, P., Mancini, M., Di Giorgio, A., Popolizio, T., Baccarelli, A., De Blasi, A., Blasi, G., & Bertolino, A.
- Affiliations
- University of Bari Aldo Moro (IT)
- University of Milan (IT)
- Sapienza University of Rome (IT)
- Casa Sollievo della Sofferenza (IT)
- Harvard University (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-04
- Volume
- 31
- Issue
- 18
- Pages
- 6692-6698
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632869
- OpenAlex
- W2008679805
- Cited by
- 188
- References
- 61
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 17 · 2016: 25 · 2015: 13 · 2014: 20 · 2013: 16 · 2012: 22
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- catechol-O-methyltransferase, DNA methylation, CpG, working memory, prefrontal cortex, gene silencing, epigenetics, peripheral blood mononuclear cells, gene expression, enzyme activity, rats
- MeSH terms
- Adult, Alleles, Animals, Catechol O-Methyltransferase, Cognition, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Polymorphism, Genetic, Surveys and Questionnaires, Stress, Psychological, Blotting, Western, Rats, Wistar, Prefrontal Cortex, DNA Methylation, Reverse Transcriptase Polymerase Chain Reaction, Rats
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