The DOI matches its Crossref record.
Telomerase, Cell Immortality, and Cancer
Abstract
An important hallmark of cancer is aberrant growth control. Genetic changes that confer a growth advantage to the tumor cell are observed on numerous levels. Some of the best understood are mutations in proto-oncogenes and tumor suppressor genes that are linked to signal transduction pathways, cell cycle control, or cell-cell/cell-matrix interactions that regulate growth, movement, differentiation, survival, apoptosis, and genetic stability (Hartwell 1992; Weinberg 1992; Hunter 1993; Runger et al. 1994; Workman 1994). However, in addition to aberrant growth control, many cancer cells possess another important feature which distinguishes them from normal somatic cells: unlimited replicative capacity.
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“A total lifetime loss of ~2-4 kb in average telomere length has been observed in human cells8-10.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [10]
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Self-citationHingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Self-citationTelomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
Self-citationTelomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108
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Metadata
- Authors
- Harley, C. B., Kim, N. W., Prowse, K. R., Weinrich, S. L., Hirsch, K. S., West, M. D., Bacchetti, S., Hirte, H. W., Counter, C. M., Greider, C. W., Piatyszek, M. A., Wright, W. E., & Shay, J. W.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Venue
- Cold Spring Harbor Symposia on Quantitative Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1994-01-01
- Volume
- 59
- Issue
- 0
- Pages
- 307-315
- ISSN
- 0091-7451 (ISSN-L)
- 1943-4456
- OpenAlex
- W2064208421
- Cited by
- 396
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 3 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- closed
- Locations
- Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- telomerase, cell immortalization, cancer, tumor growth control, proto-oncogenes, tumor suppressor, signal transduction, cell cycle regulation, apoptosis, genetic stability
- MeSH terms
- Antineoplastic Agents, Cell Transformation, Neoplastic, DNA Replication, Enzyme Inhibitors, Female, Humans, Male, Models, Biological, Neoplasms, Phenotype, Cellular Senescence, Telomerase
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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