Telomerase, Cell Immortality, and Cancer

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609

Creation of human tumour cells with defined genetic elements

Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349

Inhibition of telomerase limits the growth of human cancer cells

Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,038

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Weinrich, S. L., Pruzan, R., Ma, L., Ouellette, M. M., Tesmer, V. M., Holt, S. E., Bodnar, A. G., Lichtsteiner, S., Kim, N. W., Trager, J. B., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-498 · Cited by 975

Rules for Making Human Tumor Cells

Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951

Modelling the molecular circuitry of cancer

Hahn, W. C., & Weinberg, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc795 · Cited by 953

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science · doi:10.1126/science.277.5327.831 · Cited by 804

Telomerase maintains telomere structure in normal human cells

Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738

Telomerase and cancer therapeutics

Harley, C. B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2275 · Cited by 728

BRD4 and Cancer: going beyond transcriptional regulation

Donati, B., Lorenzini, E., & Ciarrocchi, A. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0915-9 · Cited by 742

Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)

Kim, N. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.13.2595 · Cited by 688

Comparative biology of mouse versus human cells: modelling human cancer in mice

Rangarajan, A., & Weinberg, R. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1235 · Cited by 579

Telomeres in the mouse have large inter-chromosomal variations in the number of T 2 AG 3 repeats

Zijlmans, J. M. J. M., Martens, U. M., Poon, S. S. S., Raap, A. K., Tanke, H. J., Ward, R. K., & Lansdorp, P. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7423 · Cited by 502

Pro-senescence therapy for cancer treatment

Nardella, C., Clohessy, J. G., Alimonti, A., & Pandolfi, P. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3057 · Cited by 437

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

Stewart, S. A., Hahn, W. C., O'Connor, B. F., Banner, E. N., Lundberg, A. S., Modha, P., Mizuno, H., Brooks, M. W., Fleming, M., Zimonjic, D. B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182407599 · Cited by 431

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N., & DePinho, R. A. (2000) · Science · doi:10.1126/science.287.5456.1253 · Cited by 424

Telomerase Activity in Human Breast Tumors

Hiyama, E., Gollahon, L., Kataoka, T., Kuroi, K., Yokoyama, T., Gazdar, A. F., Hiyama, K., Piatyszek, M. A., & Shay, J. W. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.116 · Cited by 421

Telomere dysfunction and tumour suppression: the senescence connection

Deng, Y., Chan, S. S., & Chang, S. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2393 · Cited by 411

Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.

Avilion, A. A., Piatyszek, M. A., Gupta, J., Shay, J. W., Bacchetti, S., & Greider, C. W. (1996) · PubMed · Cited by 399

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

Kolquist, K. A., Ellisen, L. W., Counter, C. M., Meyerson, M. M., Tan, L. K., Weinberg, R. A., Haber, D. A., & Gerald, W. L. (1998) · Nature Genetics · doi:10.1038/554 · Cited by 382

Roots and stems: stem cells in cancer

Polyák, K., & Hahn, W. C. (2006) · Nature Medicine · doi:10.1038/nm1379 · Cited by 392

Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops

Cesare, A. J., & Griffith, J. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9948-9957.2004 · Cited by 358

Inhibition of human telomerase activity by peptide nucleic acids

Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., & Corey, D. R. (1996) · Nature Biotechnology · doi:10.1038/nbt0596-615 · Cited by 342

Erosion of the telomeric single-strand overhang at replicative senescence

Stewart, S. A., Ben-Porath, I., Carey, V. J., O'Connor, B. F., Hahn, W. C., & Weinberg, R. A. (2003) · Nature Genetics · doi:10.1038/ng1127 · Cited by 335

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324

Telomeres and telomerase in aging and cancer

Harley, C. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80016-6 · Cited by 322

Genes involved in senescence and immortalization

Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00155-1 · Cited by 313

Telomere Length Abnormalities Occur Early in the Initiation of Epithelial Carcinogenesis

Meeker, A. K., Hicks, J. L., Iacobuzio-Donahue, C. A., Montgomery, E. A., Westra, W. H., Chan, T. Y., Ronnett, B. M., & De Marzo, A. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0984-03 · Cited by 306

Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

Ostenfeld, T., Caldwell, M. A., Prowse, K. R., Linskens, M. H. K., Jauniaux, E. R. M., & Svendsen, C. N. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7427 · Cited by 303

Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells

Engelhardt, M. M., Kumar, R., Albanell, J., Pettengell, R., Han, W., & Moore, M. A. S. (1997) · Blood · doi:10.1182/blood.v90.1.182 · Cited by 296

Telomeres shorten more slowly in long-lived birds and mammals than in short–lived ones

Haussmann, M. F., Winkler, D. W., O'Reilly, K. M., Huntington, C. E., Nisbet, I. C. T., & Vleck, C. M. (2003) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2003.2385 · Cited by 302

Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis.

Meeker, A. K., Hicks, J. L., Platz, E. A., March, G. E., Bennett, C., Delannoy, M. J., & Marzo, A. M. D. (2002) · PubMed · Cited by 271

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Xu, D., Wang, Q., Gruber, A., Björkholm, M., Chen, Z., Zaid, A., Selivanova, G., Peterson, C., Wiman, K. G., & Pisa, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203890 · Cited by 257

Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme

Collins, K., Kobayashi, R., & Greider, C. W. (1995) · Cell · doi:10.1016/0092-8674(95)90529-4 · Cited by 244

STEM CELL FEATURES OF BENIGN AND MALIGNANT PROSTATE EPITHELIAL CELLS

Marzo, A. M. D., Nelson, W. G., Meeker, A. K., & Coffey, D. S. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62196-7 · Cited by 239

Telomere length in leukocyte subpopulations of patients with aplastic anemia

Brümmendorf, T. H., Maciejewski, J. P., Mak, J., Young, N. S., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v97.4.895 · Cited by 233

Fifty years of skin aging

Yaar, M., Eller, M. S., & Gilchrest, B. A. (2002) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1523-1747.2002.19636.x · Cited by 233

The catalytic subunit of yeast telomerase

Counter, C. M., Meyerson, M. M., Eaton, E. N., & Weinberg, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9202 · Cited by 231

Expression of mouse telomerase catalytic subunit in embryos and adult tissues

Martı́n-Rivera, L., Herrera, E., Albar, J. P., & Blasco, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10471 · Cited by 218

Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer Cells

Li, H., Zhao, L., Yang, Z., Funder, J. W., & Liu, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33436 · Cited by 217

Human prostate cancer precursors and pathobiology

Marzo, A. M. D., Meeker, A. K., Zha, S., Luo, J., Nakayama, M., Platz, E. A., Isaacs, W. B., & Nelson, W. G. (2003) · Urology · doi:10.1016/j.urology.2003.09.053 · Cited by 204

Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells

Li, H., Zhao, L., Funder, J. W., & Liu, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16729 · Cited by 201

Telomerase regulation during entry into the cell cycle in normal human T cells.

Buchkovich, K. J., & Greider, C. W. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1443 · Cited by 198

Telomerase is not an oncogene

Harley, C. B. (2002) · Oncogene · doi:10.1038/sj.onc.1205076 · Cited by 194

High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage

Albanell, J., Engelhardt, M., Han, W., Moore, M. A. S., Lonardo, F., Rusch, V., Langenfeld, J., Klimstra, D., Venkatraman, E., & Dmitrovsky, E. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.21.1609 · Cited by 193

Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma

Inoue, K., Ozeki, Y., Suganuma, T., Sugiura, Y., & Tanaka, S. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970115)79:2 · Cited by 254

Telomeres and senescence: The history, the experiment, the future

Greider, C. W. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70105-8 · Cited by 191

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

Girotti, M. R., Salatino, M., Dalotto‐Moreno, T., & Rabinovich, G. A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182041 · Cited by 191

Human arteries engineered in vitro

McKee, J. A., Banik, S. S. R., Boyer, M. J., Hamad, N. M., Lawson, J. H., Niklason, L. E., & Counter, C. M. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor847 · Cited by 184

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

Zhang, Y., Toh, L.-L., Lau, P., & Wang, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368282 · Cited by 185

Clinical implications of telomerase in cancer

Kim, N. W. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00057-9 · Cited by 179

Real-Time Quantitative Telomeric Repeat Amplification Protocol Assay for the Detection of Telomerase Activity2

Hou, M., Xu, D., Björkholm, M., & Gruber, A. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.519 · Cited by 175

Telomerase and cancer: revisiting the telomere hypothesis

Autexier, C., & Greider, C. W. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10042-6 · Cited by 178

Telomeres, telomerase and cancer: an up-date

Dhaene, K., Marck, E. V., & Parwaresch, R. M. (2000) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280000189 · Cited by 166

The disparity between human cell senescence in vitro and lifelong replication in vivo

Rubin, H. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-675 · Cited by 171

Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

Kharbanda, S. M., Kumar, V., Dhar, S., Pandey, P., Chen, C., Majumder, P. K., Yuan, Z.-M., Whang, Y. E., Strauss, W. M., Pandita, T. K., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00483-8 · Cited by 170

Frequent amplification of the telomerase reverse transcriptase gene in human tumors.

Zhang, A., Zheng, C., Lindvall, C. J., Hou, M., Ekedahl, J., Lewensohn, R., Yan, Z.-Q., Yang, X., Henriksson, M., Blennow, E., et al. (2000) · PubMed · Cited by 156

Severe growth defect in mouse cells lacking the telomerase RNA component

Niida, H., Matsumoto, T., Satoh, H., Shiwa, M., Tokutake, Y., Furuichi, Y., & Shinkai, Y. (1998) · Nature Genetics · doi:10.1038/580 · Cited by 156

Does p53 affect organismal aging?

Donehower, L. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10104 · Cited by 155

Telomerase as a universal tumor-associated antigen for cancer immunotherapy

Vonderheide, R. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205074 · Cited by 157

Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines.

Patry, C., Bouchard, L., Labrecque, P., Gendron, D., Lemieux, B., Toutant, J., Lapointe, E., Wellinger, R. J., & Chabot, B. (2003) · PubMed · Cited by 152

Telomerase and human tumorigenesis

Stewart, S. A., & Weinberg, R. A. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0339 · Cited by 152

Histone Deacetylation Is Involved in the Transcriptional Repression of hTERT in Normal Human Cells

Cong, Y., & Bacchetti, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000637200 · Cited by 150

Telomerase activity is maintained throughout the lifespan of long-lived birds

Haussmann, M. F., Winkler, D. W., Huntington, C. E., Nisbet, I. C. T., & Vleck, C. M. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.004 · Cited by 150

Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer

Hahn, W. C. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.06.018 · Cited by 142

Telomerase activation, cellular immortalization and cancer

Hahn, W. C., & Meyerson, M. M. (2001) · Annals of Medicine · doi:10.3109/07853890109002067 · Cited by 146

Telomerase Activity and Survival of Patients With Node-Positive Breast Cancer

Clark, G. M., Osborne, C. K., Levitt, D., Wu, F., & Kim, N. W. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.24.1874 · Cited by 139

p53-dependent Down-regulation of Telomerase Is Mediated by p21

Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133

High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer.

Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J. W., Matsuura, Y., & Yokoyama, T. (2000) · PubMed · Cited by 132

Synchrony in telomere length of the human fetus

Youngren, K., Jeanclos, E., Aviv, H., Kimura, M., Stock, J., Hanna, M., Skurnick, J., Bardeguez, A., & Aviv, A. (1998) · Human Genetics · doi:10.1007/s004390050755 · Cited by 130

Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution

Ludlow, A. T., Robin, J. D., Sayed, M., Litterst, C. M., Shelton, D. N., Shay, J. W., & Wright, W. E. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku439 · Cited by 129

Functional and molecular characterization of teleost leukocytes

Miller, N. W., Wilson, M., Bfufltén, E., Stuge, T. B., Warr, G. W., & Ciem, W. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01263.x · Cited by 128

Recombinational Telomere Elongation Promoted by DNA Circles

Natarajan, S., & McEachern, M. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4512-4521.2002 · Cited by 133

Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.

Autexier, C., Pruzan, R., Funk, W. D., & Greider, C. W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00979.x · Cited by 124

Evolving views of telomerase and cancer

Blasco, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00085-0 · Cited by 123

Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells

Öğretmen, B., Schady, D. A., Usta, J. A., Wood, R., Kraveka, J. M., Luberto, C., Birbes, H., Hannun, Y. A., & Obeid, L. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100314200 · Cited by 120

Resistance to apoptosis in human cells conferred by telomerase function and telomere stability

Holt, S. E., Glinsky, V. V., Ivanova, A. B., & Glinsky, G. V. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199908)25:4 · Cited by 118

Sponges (Porifera) model systems to study the shift from immortal to senescent somatic cells: the telomerase activity in somatic cells

Koziol, C., Borojević, R., Steffen, R., & Müller, W. E. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00120-6 · Cited by 117

Molecular pathology of odontogenic tumors

Kumamoto, H. (2006) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2006.00380.x · Cited by 111

Measuring vertebrate telomeres: applications and limitations

Nakagawa, S., Gemmell, N. J., & Burke, T. A. (2004) · Molecular Ecology · doi:10.1111/j.1365-294x.2004.02291.x · Cited by 116

Tissue-specific promoters for cancer gene therapy

Saukkonen, K., & Hemminki, A. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.5.683 · Cited by 108

Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia

Xu, D., Gruber, A., Peterson, C. O., & Pisa, P. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00969.x · Cited by 107

Immortalized Bovine Satellite Cells for Cultured Meat Applications

Stout, A. J., Arnett, M. J., Chai, K. M., Guo, T., Liao, L., Mirliani, A. B., Rittenberg, M. L., Shub, M., White, E. C., Yuen, J. S. K., et al. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00216 · Cited by 106

Telomerase Activity in Female and Male Rat Germ Cells Undergoing Meiosis and in Early Embryos1

Eisenhauer, K. M., Gerstein, R. M., Chiu, C., Conti, M., & Hsueh, A. J. W. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.5.1120 · Cited by 105

Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines.

Albanell, J., Han, W., Mellado, B., Gunawardane, R. N., Scher, H. I., Dmitrovsky, E., & Moore, M. A. S. (1996) · PubMed · Cited by 104

Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

Xu, D., Erickson, S., Szeps, M., Gruber, A., Sangfelt, O., Einhorn, S., Pisa, P., & Grandér, D. (2000) · Blood · doi:10.1182/blood.v96.13.4313 · Cited by 105

Chromosome healing in mouse embryonic stem cells

Sprung, C. N., Reynolds, G. E., Jasin, M., & Murnane, J. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6781 · Cited by 102

Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia

Rossi, D., Bodoni, C. L., Genuardi, E., Monitillo, L., Drandi, D., Cerri, M., Deambrogi, C., Ricca, I., Rocci, A., Ferrero, S., et al. (2009) · Leukemia · doi:10.1038/leu.2008.399 · Cited by 100

Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.

Lev, A., Denkberg, G., Cohen, C. J., Tzukerman, M., Skorecki, K. L., Chames, P., Hoogenboom, H. R., & Reiter, Y. (2002) · PubMed · Cited by 100

Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo

Kitagawa, M., Tahara, H., Kitagawa, S., Oka, H., Kudo, Y., Sato, S., Ogawa, I., Miyaichi, M., & Takata, T. (2006) · Bone · doi:10.1016/j.bone.2006.05.022 · Cited by 99

Stem cells and neuropoiesis in the adult human brain

Steindler, D. A., & Pincus, D. W. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08096-0 · Cited by 99

Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001

Inderberg, E. M., Trachsel, S., Lislerud, K., Rasmussen, A., & Gaudernack, G. (2012) · OncoImmunology · doi:10.4161/onci.20426 · Cited by 98

Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis

Eitan, E., Tichon, A., Gazit, A., Gitler, D., Slavin, S., & Priel, E. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200212 · Cited by 82

The Relationship Between Spontaneous Telomere Loss and Chromosome Instability in a Human Tumor Cell Line

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