The CUP-SHAPED COTYLEDON3 Gene Is Required for Boundary and Shoot Meristem Formation in Arabidopsis
Open accessAbstract
From an enhancer trap screen for genes expressed in Arabidopsis embryos, we identified a gene expressed from the octant stage onward in the boundary between the two presumptive cotyledons and in a variety of postembryonic organ and meristem boundaries. This gene, CUP-SHAPED COTYLEDON3 (CUC3), encodes a putative NAC-domain transcription factor that is homologous with CUC1 and CUC2. Analysis of a CUC3 hypomorph and a putative cuc3 null mutant indicates that CUC3 function is partially redundant with that of CUC1 and CUC2 in the establishment of the cotyledon boundary and the shoot meristem, thus revealing an even higher degree of redundancy in this class of genes than was thought previously. The CUC3 expression pattern, the cuc3 phenotypes, and CUC3 expression in a series of shoot meristem mutants and transgenes suggest a primary role for CUC3 in the establishment of boundaries that contain cells with low proliferation and/or differentiation rates. The CUC-mediated establishment of such boundaries may be essential for the initiation of shoot meristems.
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CUC1-3 is expressed in the boundary between the SAM and lateral organs (cotyledons, leaves, floral organs), leaflet and rachis, and emerging teeth of simple leaves.
“| CUC1-3 | Gob (tomato (Solanum | NAC | Fusions of various organs, | SAM and lateral organs | Souer et al. (1996); Aida et al. |”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Vroemen et al. (2003)
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A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
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<i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems
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- Authors
- Vroemen, C. W., Mordhorst, A. P., Albrecht, C., Kwaaitaal, M. A. C. J., & de Vries, S. C.
- Affiliations
- Wageningen University & Research (NL)
- Laboratory of Molecular Biology, Department of Plant Sciences, Wageningen University, Wageningen, The Netherlands
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06-05
- Volume
- 15
- Issue
- 7
- Pages
- 1563-1577
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- PMC
- PMC165401
- OpenAlex
- W2100090768
- Cited by
- 480
- References
- 3
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 13 · 2023: 16 · 2022: 25 · 2021: 22 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 24 · 2016: 16 · 2015: 26 · 2014: 15 · 2013: 19 · 2012: 27
- FWCI
- 30.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Plant Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Wageningen University and Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Keywords
- CUC1, CUC2, NAC transcription factors, gene redundancy, Arabidopsis thaliana, cell proliferation and differentiation
- MeSH terms
- Base Sequence, Cloning, Molecular, Glucuronidase, Molecular Sequence Data, Mutation, Phenotype, Phylogeny, Seeds, Transcription Factors, Arabidopsis, In Situ Hybridization, Sequence Analysis, DNA, Homeodomain Proteins, Gene Expression Regulation, Plant, Gene Expression Regulation, Developmental, Meristem, Plant Shoots, DNA, Plant, Arabidopsis Proteins
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