CUPULIFORMIS establishes lateral organ boundaries in Antirrhinum

Weir, Irene; Lu, Jianping; Cook, Holly; Causier, Barry; Schwarz-Sommer, Zsuzsanna; Davies, Brendan

doi:10.1242/dev.00993

Cited by 183Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant Parasitism and Resistance

CUPULIFORMIS establishes lateral organ boundaries in Antirrhinum

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Weir, Irene, Lu, Jianping, Cook, Holly, Causier, Barry, Schwarz-Sommer, Zsuzsanna, Davies, Brendan·2004·Development

DOI 10.1242/dev.00993

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Abstract

cupuliformis mutants are defective in shoot apical meristem formation, but cup plants overcome this early barrier to development to reach maturity. CUP encodes a NAC-domain transcription factor,homologous to the Petunia NAM and Arabidopsis CUC proteins. The phenotype of cup mutants differs from those of nam and cuc1 cuc2 in that dramatic organ fusion is observed throughout development. In addition to cotyledon and floral organ fusions, severe lateral organ fusion is found in leaves and inflorescences, and the apical meristem becomes highly fasciated. These features reveal a role for CUP in the establishment of all above ground organ boundaries. Consistent with this function, CUP is expressed at the boundaries of all lateral organs and meristems. It is not currently known how NAC-domain genes act to establish organ boundaries. Here, we show that CUP directly interacts with a TCP-domain transcription factor. Members of the TCP-domain family have previously been shown to regulate organ outgrowth. Our results suggest a model for the establishment of organ boundaries based on the localised expression of NAC-domain and TCP-domain factors.

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NAM/CUC genes play a very important role during postembryonic development, as loss of these gene functions leads to defects in shoot branching in Arabidopsis, snapdragon and tomato.
“Beside their involvement in SAM formation, NAM/CUC genes also play a very important role during postembryonic development, as loss of these gene functions leads to defects in shoot branching in Arabidopsis, snapdragon and tomato (Weir et al., 2004;Hibara , 2006;Raman et al., 2008;Busch et al., 2011).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Weir et al., 2004
Gob in tomato, CUP in snapdragon, and NAM in petunia are homologous to Arabidopsis CUC1-3.
“| CUC1-3 | Gob (tomato (Solanum | NAC | Fusions of various organs, | SAM and lateral organs | Souer et al. (1996); Aida et al. |”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Weir et al. (2004)
Loss-of-function mutants of CUC1-3 have simpler leaves in compound-leaf species.
“| | lycopersicum)), CUP | | simpler leaves in compound- | (cotyledons, leaves, floral | (1997); Takada et al. (2001); |”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Weir et al. (2004)
Loss-of-function mutants of CUC1-3 have a smoother leaf margin.
“| | (snapdragon (Antirrhinum | | leaf species, smoother leaf | organs), leaflet and rachis, | Vroemen et al. (2003); Weir et al. |”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Weir et al. (2004)

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The NAC domain mediates functional specificity of CUP‐SHAPED COTYLEDON proteins
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Formation and Shaping of the Antirrhinum Flower through Modulation of the CUP Boundary Gene
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Authors: Weir, I., Lu, J., Cook, H., Causier, B., Schwarz-Sommer, Z., & Davies, B.
Affiliations: University of Leeds (GB)
Max-Planck Institut für Züchtungsforschung,Carl-von-Linné-Weg 10, 50829 Köln, Germany
Corresponding author: Davies, Brendan
ORCID: Causier, Barry
Davies, Brendan
Venue: Development
Publisher: The Company of Biologists
Published: 2004-02-15
Volume: 131
Issue: 4
Pages: 915-922
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.00993
OpenAlex: W1975151177
Cited by: 183
References: 31
Citations by year: 2026: 4 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 12 · 2012: 13
FWCI: 15.28
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Development (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Max Planck Digital Library (submittedVersion, other-oa)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Biotechnology and Biological Sciences Research Council (G19465)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
Keywords: NAC transcription factors, TCP transcription factors, shoot apical meristem, Antirrhinum, genetic interactions, inflorescence development, leaf development, fasciation
MeSH terms: Transcription Factors, Antirrhinum

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CUPULIFORMIS establishes lateral organ boundaries in Antirrhinum

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