The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Arabidopsis Receptor Kinase FLS2 Binds flg22 and Determines the Specificity of Flagellin Perception
Open accessAbstract
Flagellin, the main building block of the bacterial flagellum, acts as a pathogen-associated molecular pattern triggering the innate immune response in animals and plants. In Arabidopsis thaliana, the Leu-rich repeat transmembrane receptor kinase FLAGELLIN SENSITIVE2 (FLS2) is essential for flagellin perception. Here, we demonstrate the specific interaction of the elicitor-active epitope flg22 with the FLS2 protein by chemical cross-linking and immunoprecipitation. The functionality of this receptor was further tested by heterologous expression of the Arabidopsis FLS2 gene in tomato (Lycopersicon esculentum) cells. The perception of flg22 in tomato differs characteristically from that in Arabidopsis. Expression of Arabidopsis FLS2 conferred an additional flg22-perception system on the cells of tomato, which showed all of the properties characteristic of the perception of this elicitor in Arabidopsis. In summary, these results show that FLS2 constitutes the pattern-recognition receptor that determines the specificity of flagellin perception.
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Citations
Cites
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling
Nam, K. H., & Li, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00814-0 · Cited by 1,217
Structure and function in neuropeptides
Schwyzer, R. (1980) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1980.0115 · Cited by 38
Cited by
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Boller, T., & Felix, G. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105346 · Cited by 3,387
Self-citationA flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J. D. G., Felix, G., & Boller, T. (2007) · Nature · doi:10.1038/nature05999 · Cited by 1,923
Self-citationPlant PRRs and the Activation of Innate Immune Signaling
Macho, A. P., & Zipfel, C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.028 · Cited by 989
Elicitors, Effectors, and R Genes: The New Paradigm and a Lifetime Supply of Questions
Bent, A. F., & Mackey, D. (2007) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.45.062806.094427 · Cited by 773
Metadata
- Authors
- Chinchilla, D., Bauer, Z., Regenass, M., Boller, T., & Felix, G.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-23
- Volume
- 18
- Issue
- 2
- Pages
- 465-476
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2149863714
- Cited by
- 922
- References
- 3
- FWCI
- 27.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chinchilla, D., Bauer, Z., Regenass, M., Boller, T., & Felix, G. (2006). The Arabidopsis Receptor Kinase FLS2 Binds flg22 and Determines the Specificity of Flagellin Perception. The Plant Cell. https://doi.org/10.1105/tpc.105.036574
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