The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The AREB1 Transcription Factor Influences Histone Acetylation to Regulate Drought Responses and Tolerance in Populus trichocarpa
Open accessAbstract
Plants develop tolerance to drought by activating genes with altered levels of epigenetic modifications. Specific transcription factors are involved in this activation, but the molecular connections within the regulatory system are unclear. Here, we analyzed genome-wide acetylated lysine residue 9 of histone H3 (H3K9ac) enrichment and examined its association with transcriptomes in Populus trichocarpa under drought stress. We revealed that abscisic acid-Responsive Element (ABRE) motifs in promoters of the drought-responsive genes PtrNAC006, PtrNAC007, and PtrNAC120 are involved in H3K9ac enhancement and activation of these genes. Overexpressing these PtrNAC genes in P. trichocarpa resulted in strong drought-tolerance phenotypes. We showed that the ABRE binding protein PtrAREB1-2 binds to ABRE motifs associated with these PtrNAC genes and recruits the histone acetyltransferase unit ADA2b-GCN5, forming AREB1-ADA2b-GCN5 ternary protein complexes. Moreover, this recruitment enables GCN5-mediated histone acetylation to enhance H3K9ac and enrich RNA polymerase II specifically at these PtrNAC genes for the development of drought tolerance. CRISPR editing or RNA interference-mediated downregulation of any of the ternary members results in highly drought-sensitive P. trichocarpa. Thus, the combinatorial function of the ternary proteins establishes a coordinated histone acetylation and transcription factor-mediated gene activation for drought response and tolerance in Populus species.
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Cites
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768
Regulation of nucleosome dynamics by histone modifications
Zentner, G. E., & Henikoff, S. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2470 · Cited by 923 · cited 3×
“…promoters with differential H3K9ac for both D5/ND and D7/ND was the ABRE consensus motif for the AREB1 TF. Charron et al., 2009; Zhou et al., 2010; Li et al., 2011; Zentner and Henikoff, 2013), combinations showing hUP-gUP and hDN-gDN are most likely to represent direct effects on gene expression.”
BackgroundMsanne, J., Lin, J., Stone, J. M., & Awada, T. (2011) · Planta · doi:10.1007/s00425-011-1387-y · Cited by 335
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation.
Balasubramanian, R., Pray-Grant, M. G., Selleck, W., Grant, P. A., & Tan, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110849200 · Cited by 233
Cited by
Epigenetic regulation in plant abiotic stress responses
Chang, Y., Zhu, C., Jiang, J., Zhang, H., Zhu, J., & Duan, C. (2020) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12901 · Cited by 533
CRISPR/Cas: A powerful tool for gene function study and crop improvement
Zhang, D., Zhang, Z., Unver, T., & Zhang, B. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2020.10.003 · Cited by 373
Epigenetic Responses of Trees to Environmental Stress in the Context of Climate Change
Miryeganeh, M., & Armitage, D. W. (2025) · Biological Reviews · doi:10.1111/brv.13132 · Cited by 44
Metadata
- Authors
- Li, S., Lin, Y.-C. J., Wang, P., Zhang, B., Li, M., Chen, S., Shi, R., Tunlaya-Anukit, S., Liu, X., Wang, Z., Dai, X., Yu, J., Zhou, C., Liu, B., Wang, J. P., Chiang, V. L., & Li, W.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-11
- Volume
- 31
- Issue
- 3
- Pages
- 663-686
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2904168396
- Cited by
- 271
- References
- 9
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, S., Lin, Y.-C. J., Wang, P., Zhang, B., Li, M., Chen, S., Shi, R., Tunlaya-Anukit, S., Liu, X., Wang, Z., Dai, X., Yu, J., Zhou, C., Liu, B., Wang, J. P., Chiang, V. L., & Li, W. (2019). The AREB1 Transcription Factor Influences Histone Acetylation to Regulate Drought Responses and Tolerance in Populus trichocarpa. The Plant Cell. https://doi.org/10.1105/tpc.18.00437
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