CRISPR/Cas: A powerful tool for gene function study and crop improvement

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116 · see citing works

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.022 · Cited by 5,016 · cited 2× · see citing works

Search-and-replace genome editing without double-strand breaks or donor DNA

Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., Chen, P. J., Wilson, C., Newby, G. A., Raguram, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1711-4 · Cited by 4,767 · see citing works

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Zetsche, B., Gootenberg, J. S., Abudayyeh, O. O., Slaymaker, I. M., Makarova, K. S., Essletzbichler, P., Volz, S. E., Joung, J., John van der, O. O. S. T., Regev, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.038 · Cited by 4,750 · see citing works

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Gaj, T., Gersbach, C. A., & Barbas, C. F. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2013.04.004 · Cited by 3,820 · see citing works

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.044 · Cited by 3,696 · see citing works

Genetic screens in human cells using the CRISPR-Cas9 system

Wang, T., Wei, J. J., Sabatini, D. M., & Lander, E. S. (2014) · Science · doi:10.1126/science.1246981 · Cited by 2,856 · see citing works

Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

Gasiunas, G., Barrangou, R., Horvath, P., & Siksnys, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208507109 · Cited by 2,769 · see citing works

In vivo genome editing using Staphylococcus aureus Cas9

Ran, F. A., Cong, L., Yan, W. X., Scott, D. A., Gootenberg, J. S., Kriz, A. J., Zetsche, B., Shalem, O., Wu, X., Makarova, K. S., et al. (2015) · Nature · doi:10.1038/nature14299 · Cited by 2,687 · see citing works

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects

Kleinstiver, B. P., Pattanayak, V., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Zheng, Z., & Joung, J. K. (2016) · Nature · doi:10.1038/nature16526 · Cited by 2,673 · see citing works

Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

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Rationally engineered Cas9 nucleases with improved specificity

Slaymaker, I. M., Gao, L., Zetsche, B., Scott, D. A., Yan, W. X., & Zhang, F. (2016) · Science · doi:10.1126/science.aad5227 · Cited by 2,414 · see citing works

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

Garneau, J. E., Dupuis, M.-È., Villion, M., Romero, D. A., Barrangou, R., Boyaval, P., Fremaux, C., Horvath, P., Magadán, A. H., & Moineau, S. (2010) · Nature · doi:10.1038/nature09523 · Cited by 2,336 · see citing works

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Abudayyeh, O. O., Gootenberg, J. S., Konermann, S., Joung, J., Slaymaker, I. M., Cox, D. B. T., Shmakov, S., Makarova, K. S., Semenova, E., Станиславович, М. Л., et al. (2016) · Science · doi:10.1126/science.aaf5573 · Cited by 2,328 · see citing works

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

Makarova, K. S., Wolf, Y. I., Iranzo, J., Shmakov, S., Alkhnbashi, O. S., Brouns, S. J. J., Charpentier, E., Cheng, D. R., Haft, D. H., Horvath, P., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0299-x · Cited by 2,328 · see citing works

Crystal structure of Cas9 in complex with guide RNA and target DNA

Nishimasu, H., Ran, F. A., Hsu, P. D., Konermann, S., Shehata, S. I., Dohmae, N., Ishitani, R., Zhang, F., & Nureki, O. (2014) · Cell · doi:10.1016/j.cell.2014.02.001 · Cited by 2,306 · see citing works

Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

Mojica, F. J. M., D�ez-Villase�or, C., Garc�a-Mart�nez, J., & Soria, E. (2005) · Journal of Molecular Evolution · doi:10.1007/s00239-004-0046-3 · Cited by 2,219 · see citing works

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

Wang, Y., Cheng, X., Shan, Q., Zhang, Y., Liu, J., Gao, C., & Qiu, J.-L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2969 · Cited by 2,072 · see citing works

Identification of genes that are associated with DNA repeats in prokaryotes

Jansen, R., van Embden, J. D. A., Gaastra, W., & Schouls, L. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02839.x · Cited by 2,035 · see citing works

The CRISPR tool kit for genome editing and beyond

Adli, M. (2018) · Nature Communications · doi:10.1038/s41467-018-04252-2 · Cited by 1,642 · see citing works

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Kleinstiver, B. P., Prew, M. S., Tsai, S. Q., Topkar, V. V., Nguyen, N. T., Zheng, Z., Gonzales, A. P. W., Li, Z., Peterson, R. T., Yeh, J.-R. J., et al. (2015) · Nature · doi:10.1038/nature14592 · Cited by 1,624 · see citing works

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Hu, J. H., Miller, S. M., Geurts, M. H., Tang, W., Chen, L., Sun, N., Zeina, C. M., Gao, X., Rees, H. A., Lin, Z., et al. (2018) · Nature · doi:10.1038/nature26155 · Cited by 1,552 · see citing works

Agrobacterium -Mediated Plant Transformation: the Biology behind the “Gene-Jockeying” Tool

Gelvin, S. B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.1.16-37.2003 · Cited by 1,383 · see citing works

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Anders, C., Niewoehner, O., Duerst, A., & Jínek, M. (2014) · Nature · doi:10.1038/nature13579 · Cited by 1,319 · see citing works

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

Walton, R. T., Christie, K. A., Whittaker, M. N., & Kleinstiver, B. P. (2020) · Science · doi:10.1126/science.aba8853 · Cited by 1,233 · see citing works

DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins

Woo, J. W., Kim, J., Kwon, S. I., Corvalán, C., Cho, S. W., Kim, H., Kim, S.-G., Kim, S.-T., Choe, S., & Kim, J.-S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3389 · Cited by 1,219 · see citing works

The Barley Mlo Gene: A Novel Control Element of Plant Pathogen Resistance

Büschges, R., Hollricher, K., Panstruga, R., Simons, G., Wolter, M., Frijters, A., van Daelen, R., van der Lee, T., Diergaarde, P. J., Groenendijk, J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81912-1 · Cited by 1,194 · see citing works

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

Chen, J. S., Dagdas, Y. S., Kleinstiver, B. P., Welch, M. M., Sousa, A. A., Harrington, L. B., Sternberg, S. H., Joung, J. K., Yildiz, A., & Doudna, J. A. (2017) · Nature · doi:10.1038/nature24268 · Cited by 1,168 · see citing works

Engineering Quantitative Trait Variation for Crop Improvement by Genome Editing

Rodríguez-Leal, D., Lemmon, Z. H., Man, J., Bartlett, M. E., & Lippman, Z. B. (2017) · Cell · doi:10.1016/j.cell.2017.08.030 · Cited by 1,165 · see citing works

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

Harrington, L., Burstein, D., Chen, J. S., Páez-Espino, D., Ma, E., Witte, I. P., Cofsky, J. C., Kyrpides, N., Banfield, J., & Doudna, J. (2018) · Science · doi:10.1126/science.aav4294 · Cited by 1,106 · see citing works

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Nishimasu, H., Shi, X., Ishiguro, S., Gao, L., Hirano, S., Okazaki, S., Noda, T., Abudayyeh, O. O., Gootenberg, J. S., Mori, H., et al. (2018) · Science · doi:10.1126/science.aas9129 · Cited by 1,100 · see citing works

<scp>ARGOS</scp> 8 variants generated by <scp>CRISPR</scp> ‐Cas9 improve maize grain yield under field drought stress conditions

Shi, J., Gao, H., Wang, H., Lafitte, H. R., Archibald, R. L., Yang, M., Hakimi, S. M., Mo, H., & Habben, J. E. (2017) · Plant Biotechnology Journal · doi:10.1111/pbi.12603 · Cited by 1,029 · see citing works

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

Fonfara, I., Richter, H., Bratovič, M., Rhun, A. L., & Charpentier, E. (2016) · Nature · doi:10.1038/nature17945 · Cited by 976 · see citing works

Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes

Liang, Z., Chen, K., Li, T., Zhang, Y., Wang, Y., Zhao, Q., Liu, J., Zhang, H., Liu, C., Ran, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14261 · Cited by 964 · see citing works

Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA

Zhang, Y., Liang, Z., Zong, Y., Wang, Y., Liu, J., Chen, K., Qiu, J., & Gao, C. (2016) · Nature Communications · doi:10.1038/ncomms12617 · Cited by 906 · see citing works

Development of broad virus resistance in non‐transgenic cucumber using CRISPR/Cas9 technology

Chandrasekaran, J., Brumin, M., Wolf, D., Leibman, D., Klap, C., Pearlsman, M., Sherman, A., Arazi, T., & Gal‐On, A. (2016) · Molecular Plant Pathology · doi:10.1111/mpp.12375 · Cited by 883 · see citing works

Prime genome editing in rice and wheat

Lin, Q., Zong, Y., Xue, C., Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A. V., Raguram, A., Doman, J. L., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0455-x · Cited by 873 · cited 1× · see citing works

Genome editing in maize directed by CRISPR–Cas9 ribonucleoprotein complexes

Svitashev, S. K., Schwartz, C., Lenderts, B., Young, J. K., & Cigan, A. M. (2016) · Nature Communications · doi:10.1038/ncomms13274 · Cited by 826 · see citing works

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922

Wang, F., Wang, C., Liu, P., Lei, C., Hao, W., Gao, Y., Liu, Y., & Zhao, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154027 · Cited by 825 · see citing works

Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion

Nekrasov, V., Wang, C., Win, J., Lanz, C., Weigel, D., & Kamoun, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-00578-x · Cited by 769 · see citing works

DNA-Free Genetically Edited Grapevine and Apple Protoplast Using CRISPR/Cas9 Ribonucleoproteins

Malnoy, M., Viola, R., Jung, M., Koo, O. J., Kim, S., Kim, J., Velasco, R., & Kanchiswamy, C. N. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01904 · Cited by 766 · see citing works

Engineering canker‐resistant plants through CRISPR /Cas9‐targeted editing of the susceptibility gene Cs LOB 1 promoter in citrus

Peng, A., Chen, S., Lei, T., Xu, L., He, Y., Liu, W., Yao, L., & Zou, X. (2017) · Plant Biotechnology Journal · doi:10.1111/pbi.12733 · Cited by 732 · see citing works

In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

Kim, E., Koo, T., Park, S. W., Kim, D., Kim, K., Cho, H.-Y., Song, D. W., Lee, K. J., Jung, M. H., Kim, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms14500 · Cited by 715 · see citing works

Efficient genome engineering in human pluripotent stem cells using Cas9 from <i>Neisseria meningitidis</i>

Hou, Z., Zhang, Y., Propson, N. E., Howden, S. E., Chu, L.-F., Sontheimer, E. J., & Thomson, J. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313587110 · Cited by 681 · see citing works

Os8N3 is a host disease-susceptibility gene for bacterial blight of rice

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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

Kleinstiver, B. P., Prew, M. S., Tsai, S. Q., Nguyen, N. T., Topkar, V. V., Zheng, Z., & Joung, J. K. (2015) · Nature Biotechnology · doi:10.1038/nbt.3404 · Cited by 611 · see citing works

Low‐gluten, nontransgenic wheat engineered with CRISPR/Cas9

Sánchez‐León, S., Gil‐Humanes, J., Ozuna, C. V., Giménez, M. J., Sousa, C., Voytas, D. F., & Barro, F. (2017) · Plant Biotechnology Journal · doi:10.1111/pbi.12837 · Cited by 588 · see citing works

MicroRNAs and their regulatory roles in animals and plants

Zhang, B., Wang, Q., & Pan, X. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20869 · Cited by 553 · see citing works

Plant gene editing through de novo induction of meristems

Maher, M. F., Nasti, R. A., Vollbrecht, M., Starker, C. G., Clark, M. D., & Voytas, D. F. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0337-2 · Cited by 541 · see citing works

Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts

Andersson, M., Turesson, H., Nicolia, A., Fält, A., Samuelsson, M., & Hofvander, P. (2016) · Plant Cell Reports · doi:10.1007/s00299-016-2062-3 · Cited by 540 · see citing works

Directed evolution of CRISPR-Cas9 to increase its specificity

Lee, J. K., Jeong, E., Lee, J., Jung, M., Shin, E., Kim, Y.-H., Lee, K., Jung, I., Kim, D., Kim, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05477-x · Cited by 525 · see citing works

MicroRNA: a new target for improving plant tolerance to abiotic stress

Zhang, B. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv013 · Cited by 510 · see citing works

Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System

Li, M., Li, X., Zhou, Z., Wu, P., Fang, M., Pan, X., Lin, Q., Luo, W., Wu, G., & Li, H. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00377 · Cited by 497 · see citing works

A highly specific SpCas9 variant is identified by in vivo screening in yeast

Casini, A., Olivieri, M., Petris, G., Montagna, C., Reginato, G., Maule, G., Lorenzin, F., Prandi, D., Romanel, A., Demichelis, F., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4066 · Cited by 493 · see citing works

Generation of High-Amylose Rice through CRISPR/Cas9-Mediated Targeted Mutagenesis of Starch Branching Enzymes

Sun, Y., Jiao, G., Liu, Z., Zhang, X., Li, J., Guo, X., Du, W., Du, J., Francis, F., Zhao, Y., et al. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00298 · Cited by 469 · see citing works

Genome editing in potato via CRISPR‐Cas9 ribonucleoprotein delivery

Andersson, M., Turesson, H., Olsson, N., Fält, A., Ohlsson, P., González, M. N., Samuelsson, M., & Hofvander, P. (2018) · Physiologia Plantarum · doi:10.1111/ppl.12731 · Cited by 435 · see citing works

Engineering of CRISPR/Cas9‐mediated potyvirus resistance in transgene‐free Arabidopsis plants

Pyott, D. E., Sheehan, E., & Molnár, A. (2016) · Molecular Plant Pathology · doi:10.1111/mpp.12417 · Cited by 417 · see citing works

Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy

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Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems

Papikian, A., Liu, W., Gallego‐Bartolomé, J., & Jacobsen, S. E. (2019) · Nature Communications · doi:10.1038/s41467-019-08736-7 · Cited by 407 · see citing works

Insertion element IS987 from Mycobacterium bovis BCG is located in a hot-spot integration region for insertion elements in Mycobacterium tuberculosis complex strains

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Lycopene Is Enriched in Tomato Fruit by CRISPR/Cas9-Mediated Multiplex Genome Editing

Li, X., Wang, Y., Chen, S., Tian, H., Fu, D., Zhu, B., Luo, Y., & Zhu, H. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00559 · Cited by 392 · see citing works

Multiplexed heritable gene editing using RNA viruses and mobile single guide RNAs

Ellison, E. E., Nagalakshmi, U., Gamo, M. E., Huang, P., Dinesh‐Kumar, S. P., & Voytas, D. F. (2020) · Nature Plants · doi:10.1038/s41477-020-0670-y · Cited by 377 · see citing works

Tomato facultative parthenocarpy results from Sl AGAMOUS ‐ LIKE 6 loss of function

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Transcription at different salinities of Haloferax mediterranei sequences adjacent to partially modified Pst I sites

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CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

Billon, P., Bryant, E. E., Joseph, S. A., Nambiar, T. S., Hayward, S. B., Rothstein, R., & Ciccia, A. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.008 · Cited by 363 · see citing works

Structure and Engineering of Francisella novicida Cas9

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Highly efficient DNA-free plant genome editing using virally delivered CRISPR–Cas9

Ma, X., Zhang, X., Liu, H., & Li, Z. (2020) · Nature Plants · doi:10.1038/s41477-020-0704-5 · Cited by 359 · see citing works

Continuous evolution of SpCas9 variants compatible with non-G PAMs

Miller, S. M., Wang, T., Randolph, P. B., Arbab, M., Shen, M. W., Huang, T. P., Matuszek, Ż., Newby, G. A., Rees, H. A., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0412-8 · Cited by 347 · see citing works

CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

Kuscu, C., Parlak, M., Tufan, T., Yang, J., Szlachta, K., Wei, X., Mammadov, R., & Adli, M. (2017) · Nature Methods · doi:10.1038/nmeth.4327 · Cited by 344 · see citing works

Design of a bacterial speck resistant tomato by CRISPR /Cas9‐mediated editing of Sl JAZ 2

Ortigosa, A., Ibanez, S. G., Leonhardt, N., & Solano, R. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.13006 · Cited by 339 · see citing works

Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice

Xu, R., Yang, Y., Qin, R., Li, H., Qiu, C., Li, L., Wei, P., & Yang, J. (2016) · Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.07.003 · Cited by 332 · see citing works

Engineering abiotic stress tolerance via CRISPR/ Cas-mediated genome editing

Zafar, S. A., Zaidi, S. S., Gaba, Y., Singla-Pareek, S. L., Dhankher, O. P., Li, X., Mansoor, S., & Pareek, A. (2019) · Journal of Experimental Botany · doi:10.1093/jxb/erz476 · Cited by 316 · see citing works

Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase

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Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning

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MicroRNAs in Control of Plant Development

Li, C., & Zhang, B. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25125 · Cited by 303 · see citing works

Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize

Jiang, Y., Chai, Y., Lu, M., Han, X., Lin, Q., Zhang, Y., Zhang, Q., Zhou, Y., Wang, X., Gao, C., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02170-5 · Cited by 281 · see citing works

Combined SHOOT MERISTEMLESS and WUSCHEL trigger ectopic organogenesis in Arabidopsis

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The AREB1 Transcription Factor Influences Histone Acetylation to Regulate Drought Responses and Tolerance in Populus trichocarpa

Li, S., Lin, Y. J., Wang, P., Zhang, B., Li, M., Chen, S., Shi, R., Tunlaya‐Anukit, S., Liu, X., Wang, Z., et al. (2018) · The Plant Cell · doi:10.1105/tpc.18.00437 · Cited by 272 · see citing works

CRISPR/Cas9-Mediated SlNPR1 mutagenesis reduces tomato plant drought tolerance

Li, R., Liu, C., Zhao, R., Wang, L., Chen, L., Yu, W., Zhang, S., Sheng, J., & Shen, L. (2019) · BMC Plant Biology · doi:10.1186/s12870-018-1627-4 · Cited by 269 · see citing works

Base-Editing-Mediated Artificial Evolution of OsALS1 In Planta to Develop Novel Herbicide-Tolerant Rice Germplasms

Kuang, Y., Li, S., Ren, B., Yan, F., Spetz, C., Li, X., Zhou, X., & Zhou, H. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.01.010 · Cited by 268 · see citing works

Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System

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Manipulating the Biosynthesis of Bioactive Compound Alkaloids for Next-Generation Metabolic Engineering in Opium Poppy Using CRISPR-Cas 9 Genome Editing Technology

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MADS-Box Subfamily Gene GmAP3 from Glycine max Regulates Early Flowering and Flower Development

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