The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Simultaneous Single Unit Recording in vitro with a Photoetched Laser Deinsulated Gold Multimicroelectrode Surface
Abstract
Flat photoetched gold conductors 12 μm wide and 2 μm thick, situated on a glass plate and deinsulated at their tips with single 8 ns UV laser pulses, have been utilized to record single unit extra-cellular activity from brain ganglia of the snail Helix pomatia. A fixed array of 36 such conductors, terminating in six rows and six columns in a 0.5 mm x 1 mm area, is capable of monitoring simultaneous single unit activity from numerous neurons. Spike amplitudes of 300-500 μV are generally observed from the predominant 40 μm diameter cells of these ganglia. Giant neurons usually produce signal amplitudes of over 3 mV that are simultaneously seen by many electrodes. Signals can be monitored by merely resting a locally desheathed ganglion on the recording area under its own weight in a shallow pool of Ringer. A 10 μm diameter crater in a 3-4 μm thick insulation layer has an impedance of 2-4 MΩat 1 kHz. The capacitance of this metal electrolyte interface is about 0.5 pF/μm2, suggesting that the UV laser produces a partially colloidal gold surface. With this recessed tip design, simultaneous single unit recording from small neurons appears ensured if electrode impedances are below 4 MΩ, shunt impedances are above 30 MΩ, and glia cells are not allowed to reinsulate the end of the gold conductor.
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Cited by
Park, D.-W., Schendel, A. A., Mikael, S., Brodnick, S. K., Richner, T. J., Ness, J. P., Hayat, M. R., Atry, F., Frye, S. T., Pashaie, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms6258 · Cited by 565
Recording action potentials from cultured neurons with extracellular microcircuit electrodes
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Selective Electrical Interfaces with the Nervous System
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The Neurally Controlled Animat: Biological Brains Acting with Simulated Bodies
DeMarse, T. B., Wagenaar, D. A., Blau, A. W., & Potter, S. M. (2001) · Autonomous Robots · doi:10.1023/a:1012407611130 · Cited by 276
Metadata
- Authors
- Gross, G. W.
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 1979-05
- Volume
- BME-26
- Issue
- 5
- Pages
- 273-279
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2079316730
- Cited by
- 324
- References
- 17
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
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