Selective Electrical Interfaces with the Nervous System
Abstract
▪ Abstract To achieve selective electrical interfacing to the neural system it is necessary to approach neuronal elements on a scale of micrometers. This necessitates microtechnology fabrication and introduces the interdisciplinary field of neurotechnology, lying at the juncture of neuroscience with microtechnology. The neuroelectronic interface occurs where the membrane of a cell soma or axon meets a metal microelectrode surface. The seal between these may be narrow or may be leaky. In the latter case the surrounding volume conductor becomes part of the interface. Electrode design for successful interfacing, either for stimulation or recording, requires good understanding of membrane phenomena, natural and evoked action potential generation, volume conduction, and electrode behavior. Penetrating multimicroelectrodes have been produced as one-, two-, and three-dimensional arrays, mainly in silicon, glass, and metal microtechnology. Cuff electrodes circumvent a nerve; their selectivity aims at fascicles more than at nerve fibers. Other types of electrodes are regenerating sieves and cone-ingrowth electrodes. The latter may play a role in brain-computer interfaces. Planar substrate-embedded electrode arrays with cultured neural cells on top are used to study the activity and plasticity of developing neural networks. They also serve as substrates for future so-called cultured probes.
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The theoretical basis of electrode surface and usable characteristics and testable models of electrode design have been optimized.
“The theoretical basis of electrode surface and usable characteristics and testable models of electrode design have been optimized”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Rutten, 2002
Rutten and colleagues concluded that an electrode separation of 120 μm was optimal for selective interfacing of peripheral nerves such as the rat peroneal nerve containing around 350 alphamotor fibers.
“In a series of experimental and modeling studies, Rutten and colleagues concluded that an electrode separation of 120 m m was optimal for selective interfacing peripheral nerves, such as the rat peroneal”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Rutten, 2002
As understanding of peripheral nerves has increased and concurrent technologies have advanced, neural electrodes are beginning to enable development of clinically applicable neuroelectronic interfaces.
“As the understanding of peripheral nerves has increased and concurrent technologies have advanced, neural electrodes are beginning to enable the development of clinically applicable neuroelectronic interfaces (Rutten 2002).”
From Peripheral nerve bionic interface: a review of electrodes (2019) · cites this paper as Rutten 2002
Several options are still required to be explored for nerve-machine interfaces.
“Several options are still required to be explored for nerve-machine interfaces (Rutten, 2002).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Rutten, 2002
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Organotypic rat brain culture as in vivo-like model system
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Control electronics for a neuro-electronic interface implemented in a gate array
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Scanning the issue - Special issue on neural engineering: merging engineering and neuroscience
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Development of a solder bump technique for contacting a three-dimensional multi electrode array
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Self-citationTwo-dimensional neuro-electronic interface devices: force recruitment, selectivity and efficiency
Rutten, W. L. C., Smit, J. P. A., & Bielen, J. A. (1997) · University of Twente Research Information · Cited by 4 · see citing works
Self-citationRutten, W. L. C., van Wier, H. J., Put, J. H. M., et al. (1988) · Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.1988.94914 · Cited by 3 · see citing works
Self-citationA gate-array/multi-electrode device: circuit performance and interfacing
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Self-citation
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Neural Stimulation and Recording Electrodes
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Multi-electrode array technologies for neuroscience and cardiology
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A Review of Organic and Inorganic Biomaterials for Neural Interfaces
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Nanomaterials for Neural Interfaces
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Implanted Neural Interfaces: Biochallenges and Engineered Solutions
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Sputtered Iridium Oxide Films as Charge Injection Material for Functional Electrostimulation
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A review for the peripheral nerve interface designer
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Development of a cortical visual neuroprosthesis for the blind: the relevance of neuroplasticity
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Neural interfaces for somatosensory feedback: bringing life to a prosthesis
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Thin film multi-electrode softening cuffs for selective neuromodulation
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Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review.
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“Several options are still required to be explored for nerve-machine interfaces (Rutten, 2002).”
Microchannels as Axonal Amplifiers
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Chapter 2 Bidirectional Interfaces with the Peripheral Nervous System
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Microchannel-based regenerative scaffold for chronic peripheral nerve interfacing in amputees
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Stoyanova, I. I., van Wezel, R. J. A., & Rutten, W. L. C. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066018 · Cited by 18 · see citing works
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- Authors
- Rutten, W. L. C.
- Affiliations
- University of Twente (NL)
- Corresponding author
- Rutten, Wim L. C.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2002-08
- Volume
- 4
- Issue
- 1
- Pages
- 407-452
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2116103812
- Cited by
- 276
- References
- 114
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 14 · 2020: 6 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 6 · 2015: 16 · 2014: 20 · 2013: 20 · 2012: 17
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- University of Twente Research Information (publishedVersion)
- University of Twente Research Information (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- neurotechnology, microelectrodes, electrode design, membrane-electrode interface, volume conduction, action potential generation, cuff electrodes, nerve regeneration, brain-computer interface, neuroplasticity
- MeSH terms
- Action Potentials, Electric Stimulation, Electrodes, Electrodes, Implanted, Electrophysiology, Equipment Design, Membrane Potentials, Microelectrodes, Models, Neurological, Nerve Net, Neural Conduction, Neurons, Sensitivity and Specificity
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