Cited by 276Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignUndergraduate Neuroscience Education and Research

Selective Electrical Interfaces with the Nervous System

Rutten, Wim L. C.·2002·Annual Review of Biomedical Engineering

Abstract

▪ Abstract To achieve selective electrical interfacing to the neural system it is necessary to approach neuronal elements on a scale of micrometers. This necessitates microtechnology fabrication and introduces the interdisciplinary field of neurotechnology, lying at the juncture of neuroscience with microtechnology. The neuroelectronic interface occurs where the membrane of a cell soma or axon meets a metal microelectrode surface. The seal between these may be narrow or may be leaky. In the latter case the surrounding volume conductor becomes part of the interface. Electrode design for successful interfacing, either for stimulation or recording, requires good understanding of membrane phenomena, natural and evoked action potential generation, volume conduction, and electrode behavior. Penetrating multimicroelectrodes have been produced as one-, two-, and three-dimensional arrays, mainly in silicon, glass, and metal microtechnology. Cuff electrodes circumvent a nerve; their selectivity aims at fascicles more than at nerve fibers. Other types of electrodes are regenerating sieves and cone-ingrowth electrodes. The latter may play a role in brain-computer interfaces. Planar substrate-embedded electrode arrays with cultured neural cells on top are used to study the activity and plasticity of developing neural networks. They also serve as substrates for future so-called cultured probes.

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Crossref · 10.1146/annurev.bioeng.4.020702.153427

Cites

114 of 114 references verified0 citation errors · 0 not checkable

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  • The theoretical basis of electrode surface and usable characteristics and testable models of electrode design have been optimized.

    “The theoretical basis of electrode surface and usable characteristics and testable models of electrode design have been optimized”
  • Rutten and colleagues concluded that an electrode separation of 120 μm was optimal for selective interfacing of peripheral nerves such as the rat peroneal nerve containing around 350 alphamotor fibers.

    “In a series of experimental and modeling studies, Rutten and colleagues concluded that an electrode separation of 120 m m was optimal for selective interfacing peripheral nerves, such as the rat peroneal”
  • As understanding of peripheral nerves has increased and concurrent technologies have advanced, neural electrodes are beginning to enable development of clinically applicable neuroelectronic interfaces.

    “As the understanding of peripheral nerves has increased and concurrent technologies have advanced, neural electrodes are beginning to enable the development of clinically applicable neuroelectronic interfaces (Rutten 2002).”

    From Peripheral nerve bionic interface: a review of electrodes (2019) · cites this paper as Rutten 2002

  • Several options are still required to be explored for nerve-machine interfaces.

    “Several options are still required to be explored for nerve-machine interfaces (Rutten, 2002).”

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Authors
Rutten, W. L. C.
Affiliations
University of Twente (NL)
Corresponding author
Rutten, Wim L. C.
Venue
Annual Review of Biomedical Engineering
Published
2002-08
Volume
4
Issue
1
Pages
407-452
ISSN
  • 1523-9829 (ISSN-L)
  • 1545-4274
OpenAlex
W2116103812
Cited by
276
References
114
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 14 · 2020: 6 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 6 · 2015: 16 · 2014: 20 · 2013: 20 · 2012: 17
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • University of Twente Research Information (publishedVersion)
  • University of Twente Research Information (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
Keywords
neurotechnology, microelectrodes, electrode design, membrane-electrode interface, volume conduction, action potential generation, cuff electrodes, nerve regeneration, brain-computer interface, neuroplasticity
MeSH terms
Action Potentials, Electric Stimulation, Electrodes, Electrodes, Implanted, Electrophysiology, Equipment Design, Membrane Potentials, Microelectrodes, Models, Neurological, Nerve Net, Neural Conduction, Neurons, Sensitivity and Specificity

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