FUNCTIONAL SIGNIFICANCE OF CELL SIZE IN SPINAL MOTONEURONS
Abstract
SINCE THE BEGINNINGS OF NEUROHISTOLOGY it has been recognized that neurons within the central nervous system vary widely in size, but the functional significance of this basic observation has never emerged from the realm of speculation. The largest cells have surface areas which are at least
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According to Henneman's size principle, motor units are recruited in an orderly fashion.
“According to Henneman's size principle, motor units are recruited in an orderly fashion (Henneman et al., 1965).”
From The effects of low-load vs. high-load resistance training on muscle fiber hypertrophy: a meta-analysis. (2020) · cites this paper as Henneman et al., 1965
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“…recruited according to the size principle (Azevedo et al., 2020), a model formulated 60 years ago to explain relationships between MN anatomy and muscle force production in the cat leg (Henneman et al., 1965a, 1965b; Henneman and Olson, 1965; Mcphedran et al., 1965; Wuerker et al., 1965).”
MethodUltrasound Features of Skeletal Muscle Can Predict Kinematics of Upcoming Lower-Limb Motion
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“Finally, the structure of synaptic input to leg modules reflects correlations in MN firing rates in the form of a recruitment hierarchy, consistent with long-standing predictions of the size principle (Henneman et al., 1974, 1965b).”
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- Authors
- Henneman, E., Somjen, G., & Carpenter, D. O.
- ORCID
- Carpenter, David O.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1965-05-01
- Volume
- 28
- Issue
- 3
- Pages
- 560-580
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2396446279
- Cited by
- 2,294
- References
- 1
- Citations by year
- 2026: 55 · 2025: 64 · 2024: 44 · 2023: 72 · 2022: 68 · 2021: 64 · 2020: 64 · 2019: 66 · 2018: 61 · 2017: 60 · 2016: 52 · 2015: 57 · 2014: 67 · 2013: 51 · 2012: 64
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- cell size, spinal motoneurons, motor neuron function
- MeSH terms
- Axons, Cats, Decerebrate State, Electric Stimulation, Motor Neurons, Neuromuscular Junction, Neurophysiology, Reflex, Research, Spinal Cord, Cell Size
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