The Strength-Duration Curve
Abstract
The strength-duration curve is a plot of the lowest (threshold) current (I) required for stimulation versus pulse duration (d); it forms the basis for describing the excitability of a given tissue. It is extremely useful in all manner of studies in which excitable tissues are stimulated because it describes the manner in which the current required is changed when the pulse duration is changed. Moreover, it can be used to determine the charge and energy-duration relationships. It will be the objective of this communication to show how the essential constants can be obtained.
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The relationship between charge and neuron activation is defined by the strength-duration curve, the threshold current amplitude required for neuron stimulation for a given pulse width.
“The relationship between charge and neuron activation is defined by the strength-duration curve, the threshold current amplitude required for neuron stimulation for a given pulse width [115], [116]”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [115]
Cites
Sur la possibilite de rendre comparables entre eux les appareils servant a l'excitation electrique.
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Excitability characteristics of the A- and C-fibers in a peripheral nerve
Li, C. L., & Bak, A. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90236-3 · Cited by 120 · see citing works
Myocardial Stimulation with Ultrashort Duration Current Pulses
Pearce, J. A., BOURLAND, J. D., NEILSEN, W., et al. (1982) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1982.tb02191.x · Cited by 60 · see citing works
Self-citationTHE ELECTRICAL DIAGNOSIS OF PERIPHERAL NERVE INJURY
Ritchie, A. E. (1944) · Brain · doi:10.1093/brain/67.4.314 · Cited by 26 · see citing works
THE RESPONSE OF HUMAN SENSORY NERVES TO CURRENTS OF SHORT DURATION
Adrian, E. D. (1920) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192004000-00032 · Cited by 2 · see citing works
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Siebner, H. R., Funke, K., Aberra, A. S., Antal, A., Bestmann, S., Chen, R., Classen, J., Davare, M., Di Lazzaro, V., Fox, P. T., et al. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.04.022 · Cited by 566 · see citing works
Strength-duration properties of human peripheral nerve
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A mm-Sized Wireless Implantable Device for Electrical Stimulation of Peripheral Nerves
Charthad, J., Chang, T. C., Liu, Z., Sawaby, A., Weber, M. J., Baker, S., Gore, F., Felt, S. A., & Arbabian, A. (2018) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2018.2799623 · Cited by 230 · see citing works
Niederhoffer, T., Vanhoestenberghe, A., & Lancashire, H. T. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acb084 · Cited by 38 · see citing works
Phosphene perceptions and safety of chronic visual cortex stimulation in a blind subject
Niketeghad, S., Muralidharan, A., Patel, U., Dorn, J. D., Bonelli, L., Greenberg, R. J., & Pouratian, N. (2020) · Journal of Neurosurgery · doi:10.3171/2019.3.jns182774 · Cited by 33 · see citing works
Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review
Habibollahi, M., Jiang, D., Lancashire, H. T., & Demosthenous, A. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3430038 · Cited by 11 · see citing works
“The relationship between charge and neuron activation is defined by the strength-duration curve, the threshold current amplitude required for neuron stimulation for a given pulse width [115], [116], thus sufficient charge injection is required for neuron activation.”
- Authors
- Geddes, L. A., & Bourland, J. D.
- Affiliations
- Purdue University West Lafayette (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 1985-06
- Volume
- BME-32
- Issue
- 6
- Pages
- 458-459
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2111920833
- Cited by
- 128
- References
- 5
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- strength-duration curve, threshold current, pulse duration, excitable tissues
- MeSH terms
- Chronaxy, Electric Stimulation, Humans
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