In Vivo Penetration Mechanics and Mechanical Properties of Mouse Brain Tissue at Micrometer Scales

Sharp, A.A.; Ortega, A.M.; Restrepo, D.; Curran-Everett, D.; Gall, K.

doi:10.1109/tbme.2008.2003261

Cited by 157Neuroscience and Neural EngineeringElasticity and Material ModelingCellular Mechanics and Interactions

In Vivo Penetration Mechanics and Mechanical Properties of Mouse Brain Tissue at Micrometer Scales

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Sharp, A.A., Ortega, A.M., Restrepo, D., Curran-Everett, D., Gall, K.·2009·IEEE Transactions on Biomedical Engineering

DOI 10.1109/tbme.2008.2003261PMC PMC2855535

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Abstract

Substantial advancement in the understanding of the neuronal basis of behavior and the treatment of neurological disorders has been achieved via the implantation of various devices into the brain. To design and optimize the next generation of neuronal implants while striving to minimize tissue damage, it is necessary to understand the mechanics of probe insertion at relevant length scales. Unfortunately, a broad-based understanding of brain-implant interactions at the necessary micrometer scales is largely missing. This paper presents a generalizable description of the micrometer-scale penetration mechanics and material properties of mouse brain tissue in vivo. Cylindrical stainless steel probes were inserted into the cerebral cortex and olfactory bulb of mice. The effects of probe size, probe geometry, insertion rate, insertion location, animal age, and the presence of the dura and pia on the resulting forces were measured continuously throughout probe insertion and removal. Material properties (modulus, cutting force, and frictional force) were extracted using mechanical analysis. The use of rigid, incompressible, cylindrical probes allows for a general understanding of how probe design and insertion methods influence the penetration mechanics of brain tissue in vivo that can be applied to the quantitative design of most future implantable devices.

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As implants fail to move together with tissue, compression and sliding along the interface cause damage to surrounding tissue.
“As implants fail to move together with tissue, the compression and sliding along the interface causes damage to the surrounding tissue (Goldstein and Salcman, 1973; Sharp et al., 2009; Barrese et al., 2016).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Sharp et al., 2009
The Results (Section III.A and III.C; page unavailable) describe tissue compression during probe insertion and friction between the probe and tissue during removal. The Discussion (Section IV.B; page unavailable) links insertion to tissue tearing. The paper does not establish that implants fail to move with tissue or that compression and sliding from that mismatch damage surrounding tissue after implantation. (LLM, conf=0.83)
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Real-time prediction of hand trajectory by ensembles of cortical neurons in primates
Wessberg, J., Stambaugh, C. R., Kralik, J. D., Beck, P. D., Laubach, M., Chapin, J. K., Kim, J., Biggs, S. J., Srinivasan, M. A., & Nicolelis, M. A. L. (2000) · Nature · doi:10.1038/35042582 · Cited by 1,491 · see citing works
The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218 · see citing works
Force Modeling for Needle Insertion Into Soft Tissue
Okamura, A. M., Simone, C., & O'Leary, M. D. (2004) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2004.831542 · Cited by 832 · see citing works
Brain responses to micro-machined silicon devices
Szarowski, D. H., Andersen, M. D., Retterer, S. T., Spence, A. J., Isaacson, M. S., Craighead, H. G., Turner, J. N., & Shain, W. G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03023-3 · Cited by 798 · see citing works
Multiple comparisons: philosophies and illustrations
Curran-Everett, D. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r1 · Cited by 743 · see citing works
Self-citation
Introduction to Contact Mechanics
Fischer-Cripps, A. C. (2007) · Mechanical engineering series · doi:10.1007/978-0-387-68188-7 · Cited by 729 · see citing works
Mechanical properties of brain tissue in-vivo: experiment and computer simulation
Miller, K., Chinzei, K., Orssengo, G. J., & Bednarz, P. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(00)00120-2 · Cited by 501 · see citing works
The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1950) · JAMA · doi:10.1001/jama.1950.02920160086033 · Cited by 495 · see citing works
Are in vivo and in situ brain tissues mechanically similar?
Gefen, A., & Margulies, S. S. (2004) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2003.12.032 · Cited by 420 · see citing works
Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex
Williams, J. C., Rennaker, R. L., & Kipke, D. R. (1999) · Brain Research Protocols · doi:10.1016/s1385-299x(99)00034-3 · Cited by 396 · see citing works
A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex
Subbaroyan, J., Martin, D. C., & Kipke, D. R. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/4/006 · Cited by 368 · see citing works
Odor- and context-dependent modulation of mitral cell activity in behaving rats
Kay, L. M., & Laurent, G. (1999) · Nature Neuroscience · doi:10.1038/14801 · Cited by 357 · see citing works
Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion
Bjornsson, C. S., Oh, S., Al‐Kofahi, Y., Lim, Y.-J., Smith, K. L., Turner, J. N., De, S., Roysam, B., Shain, W. G., & Kim, S. J. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/3/002 · Cited by 330 · see citing works
A realistic brain tissue phantom for intraparenchymal infusion studies
Chen, Z.-J., Gillies, G. T., Broaddus, W. C., Prabhu, S. S., Fillmore, H. L., Mitchell, R. M., Corwin, F. D., & Fatouros, P. P. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.2.0314 · Cited by 324 · see citing works
Age-Dependent Changes in Material Properties of the Brain and Braincase of the Rat
Gefen, A., Gefen, N., Zhu, Q., Raghupathi, R., & Margulies, S. S. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770802853 · Cited by 299 · see citing works
Estimating the effective Young's modulus of soft tissues from indentation tests—nonlinear finite element analysis of effects of friction and large deformation
Zhang, M., Zheng, Y., & Mak, A. F. T. (1997) · Medical Engineering & Physics · doi:10.1016/s1350-4533(97)00017-9 · Cited by 282 · see citing works
Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task
Laubach, M., Wessberg, J., & Nicolelis, M. A. L. (2000) · Nature · doi:10.1038/35014604 · Cited by 275 · see citing works
Frequency discrimination in the sense of flutter: psychophysical measurements correlated with postcentral events in behaving monkeys
Mountcastle, V. B., Steinmetz, M., & Romo, R. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03032.1990 · Cited by 243 · see citing works
Experimental Investigation Into the Deep Penetration of Soft Solids by Sharp and Blunt Punches, With Application to the Piercing of Skin
Shergold, O. A., & Fleck, N. A. (2005) · Journal of Biomechanical Engineering · doi:10.1115/1.1992528 · Cited by 232 · see citing works
Techniques for Chronic, Multisite Neuronal Ensemble Recordings in Behaving Animals
Kralik, J. D., Dimitrov, D. F., Krupa, D. J., Katz, D. B., Cohen, D., & Nicolelis, M. A. L. (2001) · Methods · doi:10.1006/meth.2001.1231 · Cited by 162 · see citing works
Strength characterization of silicon microprobes in neurophysiological tissues
Najafi, K., & Hetke, J. F. (1990) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.55638 · Cited by 146 · see citing works
In-vivo implant mechanics of flexible, silicon-based ACREO microelectrode arrays in rat cerebral cortex
Jensen, W., Yoshida, K., & Hofmann, U. (2006) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2006.872824 · Cited by 115 · see citing works
Toward a self-deploying shape memory polymer neuronal electrode
Sharp, A. A., Panchawagh, H. V., Ortega, A., Artale, R., Richardson-Burns, S., Finch, D. S., Gall, K., Mahajan, R. L., & Restrepo, D. (2006) · Journal of Neural Engineering · doi:10.1088/1741-2560/3/4/l02 · Cited by 113 · see citing works
Self-citation
Taste-Specific Neuronal Ensembles in the Gustatory Cortex of Awake Rats
Katz, D. B., Simon, S. A., & Nicolelis, M. A. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01850.2002 · Cited by 108 · see citing works
Target Selection for Saccadic Eye Movements: Direction-Selective Visual Responses in the Superior Colliculus
Horwitz, G. D., & Newsome, W. T. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.5.2527 · Cited by 88 · see citing works
Integration of bilateral whisker stimuli in rats: role of the whisker barrel cortices.
Shuler, M. G. H., Krupa, D., & Nicolelis, M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.86 · Cited by 75 · see citing works
Measurement of the force required to move a neurosurgical probe through in vivo human brain tissue
Howard, M. A., Abkes, B. A., Ollendieck, M. C., Noh, M. D., Ritter, C., & Gillies, G. T. (1999) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.771205 · Cited by 63 · see citing works
Elastic behavior of brain tissue in vivo
Walsh, E., & Schettini, A. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.4.1058 · Cited by 54 · see citing works
Measurement of friction on straight catheters in in vitro brain and phantom material
Ritter, R. C., Quate, E. G., Gillies, G. T., Grady, M. S., Howard, M. A., & Broaddus, W. C. (1998) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.664203 · Cited by 33 · see citing works
Multielectrode Recording from the Cerebellum
Schwarz, C., & Welsh, J. P. (1998) · Frontiers in neuroscience · doi:10.1201/9781420048254.ch5 · Cited by 23 · see citing works
On measurement of brain elastic response in vivo
Walsh, E. K., Furniss, W. W., & Schettini, A. (1977) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1977.232.1.r27 · Cited by 21 · see citing works
Feasibility of a central nervous system auditory prosthesis: penetrating microelectrode insertion force studies.
Portillo, F., Mobley, P. L., Moore, J., & McCreery, D. B. (1995) · PubMed · Cited by 7 · see citing works

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Materials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
Carnicer-Lombarte, A., Chen, S.-T., Malliaras, G. G., & Barone, D. G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.622524 · Cited by 454 · see citing works
“As implants fail to move together with tissue, the compression and sliding along the interface causes damage to the surrounding tissue (Goldstein and Salcman, 1973; Sharp et al., 2009; Barrese et al., 2016).”
Background
Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes
Xie, C., Liu, J., Fu, T.-M., Dai, X., Zhou, W., & Lieber, C. M. (2015) · Nature Materials · doi:10.1038/nmat4427 · Cited by 404 · see citing works
A Materials Roadmap to Functional Neural Interface Design
Wellman, S. M., Eles, J. R., Ludwig, K. A., Seymour, J. P., Michelson, N. J., McFadden, W. E., Vazquez, A. L., & Kozai, T. D. Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701269 · Cited by 389 · see citing works
Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
Jorfi, M., Skousen, J. L., Weder, C., & Capadona, J. R. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/011001 · Cited by 384 · see citing works
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
Turtaev, S., Leite, I. T., Altwegg‐Boussac, T., Pakan, J. M. P., Rochefort, N. L., & Čižmár, T. (2018) · Light Science & Applications · doi:10.1038/s41377-018-0094-x · Cited by 348 · see citing works
Flexible, Penetrating Brain Probes Enabled by Advances in Polymer Microfabrication
Weltman, A., Yoo, J. J., & Meng, E. F. (2016) · Micromachines · doi:10.3390/mi7100180 · Cited by 180 · see citing works
Slow insertion of silicon probes improves the quality of acute neuronal recordings
Fiáth, R., Márton, A. L., Mátyás, F., Pinke, D., Márton, G., Tóth, K., & Ulbert, I. (2019) · Scientific Reports · doi:10.1038/s41598-018-36816-z · Cited by 163 · see citing works
Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal
Cho, W. K., Ankrum, J. A., Guo, D., Chester, S. A., Yang, S. Y., Kashyap, A., Campbell, G. A., Wood, R. J., Rijal, R. K., Karnik, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216441109 · Cited by 155 · see citing works
Mechanical and Biological Interactions of Implants with the Brain and Their Impact on Implant Design
Prodanov, D., & Delbeke, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00011 · Cited by 148 · see citing works
Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants
Golabchi, A., Wu, B., Cao, B., Bettinger, C. J., & Cui, X. T. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119519 · Cited by 138 · see citing works
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering
Lewitus, D. Y., Landers, J., Branch, J. R., Smith, K. L., Callegari, G., Kohn, J., & Neimark, A. V. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201002429 · Cited by 137 · see citing works
Silk as a Multifunctional Biomaterial Substrate for Reduced Glial Scarring around Brain‐Penetrating Electrodes
Tien, L. W., Wu, F., Tang‐Schomer, M. D., Yoon, E., Omenetto, F. G., & Kaplan, D. L. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201203716 · Cited by 136 · see citing works
Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface
Michelson, N. J., Vazquez, A. L., Eles, J. R., Salatino, J. W., Purcell, E. K., Williams, J. J., Cui, X. T., & Kozai, T. D. Y. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa9dae · Cited by 126 · see citing works
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging.
Turtaev, S., Leite, I. T., Altwegg‐Boussac, T., Pakan, J. M. P., Rochefort, N. L., & Čižmár, T. (2018) · DZNE Pub · Cited by 134 · see citing works
Long-term changes in the material properties of brain tissue at the implant–tissue interface
Sridharan, A., Rajan, S. D., & Muthuswamy, J. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066001 · Cited by 133 · see citing works
Emerging Soft Conductors for Bioelectronic Interfaces
Gao, D., Parida, K., & Lee, P. S. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201907184 · Cited by 129 · see citing works
Tracking neural activity from the same cells during the entire adult life of mice
Zhao, S., Tang, X., Tian, W., Partarrieu, S., Liu, R., Shen, H., Lee, J. Y., Guo, S., Lin, Z., & Jia Liu, B. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01267-x · Cited by 128 · see citing works
Tool-tissue forces in surgery: A systematic review
Golahmadi, A. K., Khan, D. Z., Mylonas, G. P., & Marcus, H. J. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102268 · Cited by 110 · see citing works
Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording
He, F., Lycke, R., Ganji, M., Xie, C., & Luan, L. (2020) · iScience · doi:10.1016/j.isci.2020.101387 · Cited by 98 · see citing works
FEF inactivation with improved optogenetic methods
Acker, L., Pino, E. N., Boyden, E. S., & Desimone, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610784113 · Cited by 95 · see citing works
In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain
Casanova, F., Carney, P. R., & Sarntinoranont, M. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.012 · Cited by 94 · see citing works
Neural tissue-microelectrode interaction: Brain micromotion, electrical impedance, and flexible microelectrode insertion
Sharafkhani, N., Kouzani, A. Z., Adams, S. D., Long, J. M., Lissorgues, G., Rousseau, L., & Orwa, J. O. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109388 · Cited by 85 · see citing works
Ultrafast resorbing polymers for use as carriers for cortical neural probes
Lewitus, D. Y., Smith, K. L., Shain, W. G., & Kohn, J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.02.027 · Cited by 86 · see citing works
Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices
Sung, C., Jeon, W., Nam, K. S., Kim, Y., Butt, H., & Park, S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00872a · Cited by 85 · see citing works
A Parylene Neural Probe Array for Multi-Region Deep Brain Recordings
Wang, X., Weltman, A., Xu, H., Slingsby-Smith, Z., Lecomte, A., Scholten, K., Song, D. B., & Meng, E. F. (2020) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2020.3000235 · Cited by 83 · see citing works
A Flexible Depth Probe Using Liquid Crystal Polymer
Lee, S., Jun, S. B., Lee, H. J., Kim, J.-H., Lee, S. W., Im, C., Shin, H., Chang, J. W., & Kim, S. J. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2196274 · Cited by 83 · see citing works
Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes
Roh, H., Yoon, Y. J., Park, J. S., Kang, D.-H., Kwak, S. M., Lee, B. C., & Im, M. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00778-1 · Cited by 79 · see citing works
Effect of Insertion Speed on Tissue Response and Insertion Mechanics of a Chronically Implanted Silicon-Based Neural Probe
Welkenhuysen, M., Andrei, A., Ameye, L., Eberle, W., & Nuttin, B. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2166963 · Cited by 71 · see citing works
A comparison of insertion methods for surgical placement of penetrating neural interfaces
Thielen, B., & Meng, E. F. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abf6f2 · Cited by 72 · see citing works
Translational Neuroelectronics
Jastrzebska‐Perfect, P., Chowdhury, S., Spyropoulos, G. D., Zhao, Z., Cea, C., Gelinas, J. N., & Khodagholy, D. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909165 · Cited by 64 · see citing works
Influence of resveratrol release on the tissue response to mechanically adaptive cortical implants
Nguyen, J. K., Jorfi, M., Buchanan, K. L., Park, D. J., Foster, E. J., Tyler, D. J., Rowan, S. J., Weder, C., & Capadona, J. R. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.001 · Cited by 62 · see citing works
A Force-Sensing Bipolar Forceps to Quantify Tool–Tissue Interaction Forces in Microsurgery
Zareinia, K., Maddahi, Y., Gan, L. S., Ghasemloonia, A., Lama, S., Sugiyama, T., Yang, F. W., & Sutherland, G. R. (2016) · IEEE/ASME Transactions on Mechatronics · doi:10.1109/tmech.2016.2563384 · Cited by 59 · see citing works
A response surface model predicting thein vivoinsertion behavior of micromachined neural implants
Andrei, A., Welkenhuysen, M., Nuttin, B., & Eberle, W. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/1/016005 · Cited by 58 · see citing works
A hybrid silicon–parylene neural probe with locally flexible regions
Kim, E. G. R., John, J. K., Tu, H., Zheng, Q., Loeb, J. A., Zhang, J., & Xu, Y. P. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.01.048 · Cited by 55 · see citing works
Forces exerted during microneurosurgery: a cadaver study
Marcus, H. J., Zareinia, K., Gan, L. S., Yang, F. W., Lama, S., Yang, G., & Sutherland, G. R. (2014) · International Journal of Medical Robotics and Computer Assisted Surgery · doi:10.1002/rcs.1568 · Cited by 54 · see citing works
In Vivo Validation of Custom-Designed Silicon-Based Microelectrode Arrays for Long-Term Neural Recording and Stimulation
Han, M., Manoonkitiwongsa, P. S., Wang, C. X., & McCreery, D. B. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2172440 · Cited by 54 · see citing works
Mechanical characterization of the P56 mouse brain under large-deformation dynamic indentation
MacManus, D. B., Pierrat, B., Murphy, J. G., & Gilchrist, M. D. (2016) · Scientific Reports · doi:10.1038/srep21569 · Cited by 54 · see citing works
A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain
Joo, H. R., Fan, J. L., Chen, S., Pebbles, J. A., Liang, H., Chung, J. E., Yorita, A. M., Tooker, A., Tolosa, V. M., Geaghan-Breiner, C., et al. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab2b2e · Cited by 53 · see citing works
Transparent, Flexible, Penetrating Microelectrode Arrays with Capabilities of Single‐Unit Electrophysiology
Seo, K. J., Artoni, P., Qiang, Y., Zhong, Y., Han, X., Shi, Z., Yao, W., Fagiolini, M., & Fang, H. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800276 · Cited by 53 · see citing works
Engineering strategies towards overcoming bleeding and glial scar formation around neural probes
Otte, E., Vlachos, A., & Asplund, M. (2022) · Cell and Tissue Research · doi:10.1007/s00441-021-03567-9 · Cited by 50 · see citing works
Quantification of Forces During a Neurosurgical Procedure: A Pilot Study
Gan, L. S., Zareinia, K., Lama, S., Maddahi, Y., Yang, F. W., & Sutherland, G. R. (2015) · World Neurosurgery · doi:10.1016/j.wneu.2015.04.001 · Cited by 48 · see citing works
Mechanical characterisation of brain tissue up to 35% strain at 1, 10, and 100/s using a custom-built micro-indentation apparatus
MacManus, D. B., Murphy, J. G., & Gilchrist, M. D. (2018) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2018.07.025 · Cited by 45 · see citing works
Influence of Needle Insertion Speed on Backflow for Convection-Enhanced Delivery
Casanova, F., Carney, P. R., & Sarntinoranont, M. (2012) · Journal of Biomechanical Engineering · doi:10.1115/1.4006404 · Cited by 45 · see citing works
Fabrication and characterization of the flexible neural microprobes with improved structural design
Fomani, A. A., & Mansour, R. R. (2011) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2011.04.024 · Cited by 44 · see citing works
Integration of silicon-based neural probes and micro-drive arrays for chronic recording of large populations of neurons in behaving animals
Michon, F., Aarts, A. A. A., Holzhammer, T., Ruther, P., Borghs, G., McNaughton, B. L., & Kloosterman, F. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/4/046018 · Cited by 42 · see citing works
Bevel angle study of flexible hollow needle insertion into biological mimetic soft-gel: Simulation and experimental validation
Jushiddi, M. G., Cahalane, R. M. E., Byrne, M., Mani, A., Silien, C., Tofail, S. A. M., Mulvihill, J. J., & Tiernan, P. (2020) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2020.103896 · Cited by 43 · see citing works
Dextran as a Resorbable Coating Material for Flexible Neural Probes
Kil, D., Carmona, M. B., Ceyssens, F., Deprez, M., Brancato, L., Nuttin, B., Balschun, D., & Puers, R. (2019) · Micromachines · doi:10.3390/mi10010061 · Cited by 41 · see citing works
Control of neural probe shank flexibility by fluidic pressure in embedded microchannel using PDMS/PI hybrid substrate
Rezaei, S., Xu, Y., & Pang, S. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220258 · Cited by 41 · see citing works
Double-Layer Flexible Neural Probe With Closely Spaced Electrodes for High-Density in vivo Brain Recordings
Pimenta, S., Rodrigues, J. A., Machado, F., Ribeiro, J. F., Maciel, M. J., Bondarchuk, O. B., Monteiro, P., Gaspar, J., Correia, J. H., & Jacinto, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.663174 · Cited by 40 · see citing works
Dynamic mechanical properties of murine brain tissue using micro-indentation
MacManus, D. B., Pierrat, B., Murphy, J. G., & Gilchrist, M. D. (2015) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2015.06.028 · Cited by 39 · see citing works
Nanomechanics and Histopathology as Diagnostic Tools to Characterize Freshly Removed Human Brain Tumors
Cieśluk, M., Pogoda, K., Deptuła, P., Werel, P., Kułakowska, A., Kochanowicz, J., Mariak, Z. D., Łysoń, T., Reszeć, J., & Bucki, R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s270147 · Cited by 38 · see citing works
LED Optrode with Integrated Temperature Sensing for Optogenetics
Goncalves, S. B., Palha, J. M. D. C., Fernandes, H. C., Souto, M. R., Pimenta, S., Dong, T., Yang, Z., Ribeiro, J. F., & Correia, J. H. (2018) · Micromachines · doi:10.3390/mi9090473 · Cited by 38 · see citing works
Evaluation of the friction coefficient, the radial stress, and the damage work during needle insertions into agarose gels
Urrea, F. A., Casanova, F., Orozco, G. A., & García, J. J. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.11.024 · Cited by 37 · see citing works
Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links
Patil, A. C., Xiong, Z., & Thakor, N. V. (2020) · Small Methods · doi:10.1002/smtd.202000274 · Cited by 37 · see citing works
Research Progress on the Flexibility of an Implantable Neural Microelectrode
Zhao, H., Liu, R., Zhang, H., Cao, P., Liu, Z., & Li, Y. (2022) · Micromachines · doi:10.3390/mi13030386 · Cited by 36 · see citing works
Experimental study on the mechanical interaction between silicon neural microprobes and rat dura mater during insertion
Fekete, Z., Németh, A., Márton, G., Ulbert, I., & Pongracz, A. (2015) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5401-y · Cited by 34 · see citing works
CHIME: CMOS-Hosted in vivo Microelectrodes for Massively Scalable Neuronal Recordings
Köllő, M., Rácz, R., Hanna, M.-E., Obaid, A., Angle, M. R., Wray, W., Kong, Y., Hierlemann, A. R., Müller, J., Melosh, N. A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00834 · Cited by 31 · see citing works
A Method of Flexible Micro-Wire Electrode Insertion in Rodent for Chronic Neural Recording and a Device for Electrode Insertion
Arafat, M. A., Rubin, L. N., Jefferys, J. G. R., & Irazoqui, P. P. (2019) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2019.2932032 · Cited by 30 · see citing works
Ultra-sensitive measurement of brain penetration with microscale probes for brain machine interface considerationsPreprint
Obaid, A., Wu, Y., Hanna, M., Nix, W. D., Ding, J., & Melosh, N. A. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/454520 · Cited by 29 · see citing works
Advancing the interfacing performances of chronically implantable neural probes in the era of CMOS neuroelectronics
Perna, A., Angotzi, G. N., Berdondini, L., & Ribeiro, J. F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1275908 · Cited by 28 · see citing works
Electrothermal Microactuators With Peg Drive Improve Performance for Brain Implant Applications
Anand, S., Sutanto, J., Baker, M. S., Okandan, M., & Muthuswamy, J. (2012) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2012.2203789 · Cited by 28 · see citing works
Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes
Obaid, A., Hanna, M.-E. S., Huang, S.-W., Hu, Y.-T., Jáidar, O., Nix, W. D., Ding, J., Melosh, N. A., & Wu, Y. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2529147123 · Cited by 28 · see citing works
Minimally-invasive insertion strategy and in vivo evaluation of multi-shank flexible intracortical probes
Srikantharajah, K., Quintela, R. M., Doerenkamp, K., Kampa, B. M., Musall, S., Rothermel, M., & Offenhäusser, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-97940-x · Cited by 28 · see citing works
Focal, remote-controlled, chronic chemical modulation of brain microstructures
Ramadi, K. B., Dağdeviren, C., Spencer, K. C., Joe, P., Cotler, M. J., Rousseau, E. B., Nunez-Lopez, C., Graybiel, A. M., Langer, R., & Cima, M. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804372115 · Cited by 26 · see citing works
Fabrication and characterization of thermocouple probe for use in intracellular thermometry
Rajagopal, M. C., Valavala, K. V., Gelda, D., Ma, J., & Sinha, S. (2018) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2018.02.004 · Cited by 25 · see citing works
Tetherless Mobile Micro-Surgical Scissors Using Magnetic Actuation
Onaizah, O., & Diller, E. (2019) · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings · doi:10.1109/icra.2019.8793564 · Cited by 26 · see citing works
Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka, Y., Nomoto, T., Shiki, T., Sakata, Y., Shimada, Y., Hayashida, Y., & Yagi, T. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab0b80 · Cited by 26 · see citing works
Rigidity‐Tunable Materials for Soft Engineering Systems
Roh, Y., Lim, D., Kang, M., Cho, J., Han, S., & Ko, S. H. (2024) · Advanced Engineering Materials · doi:10.1002/adem.202400563 · Cited by 24 · see citing works
Insertion mechanics of amorphous SiC ultra-micro scale neural probes
Geramifard, N., Dousti, B., Nguyen, C. K., Abbott, J., Cogan, S. F., & Varner, V. D. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac5bf4 · Cited by 24 · see citing works
Computational models of cortical folding: A review of common approaches
Darayi, M., Hoffman, M. E., Sayut, J., Wang, S., Demirci, N., Consolini, J., & Holland, M. A. (2021) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2021.110851 · Cited by 23 · see citing works
Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays
McNamara, I., Wellman, S. M., Li, L., Eles, J. R., Savya, S. P., Sohal, H. S., Angle, M. R., & Kozai, T. D. Y. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad36e1 · Cited by 24 · see citing works
Microscale characterisation of the time-dependent mechanical behaviour of brain white matter
Jamal, A., Bernardini, A., & Dini, D. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104917 · Cited by 22 · see citing works
Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants
Kumosa, L. S. (2023) · Advanced Science · doi:10.1002/advs.202205095 · Cited by 21 · see citing works
Flexible High-Resolution Force and Dimpling Measurement System for Pia and Dura Penetration During In Vivo Microelectrode Insertion Into Rat Brain
Chen, L., Hartner, J. P., Dong, T., Li, A. D. R., Watson, B. O., & Shih, A. J. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3070781 · Cited by 21 · see citing works
Elastic and viscoelastic mechanical properties of brain tissues on the implanting trajectory of sub-thalamic nucleus stimulation
Li, Y., Deng, J., Zhou, J., & Li, X. (2016) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-016-5775-5 · Cited by 21 · see citing works
Parylene-Based Electrochemical-MEMS Force Sensor for Studies of Intracortical Probe Insertion Mechanics
Kim, B., Gutierrez, C. A., & Meng, E. F. (2015) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2015.2420043 · Cited by 20 · see citing works
Flexible deep brain neural probes based on a parylene tube structure
Zhao, Z., Kim, E. H., Luo, H., Zhang, J., & Xu, Y. P. (2017) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/aa9d61 · Cited by 20 · see citing works
Manufacturing Processes of Implantable Microelectrode Array for In Vivo Neural Electrophysiological Recordings and Stimulation: A State-Of-the-Art Review
Yi, D., Yao, Y., Wang, Y., & Chen, L. (2022) · Journal of Micro and Nano-Manufacturing · doi:10.1115/1.4063179 · Cited by 23 · see citing works
Design, fabrication, and implantation of invasive microelectrode arrays as in vivo brain machine interfaces: A comprehensive review
Yi, D., Yao, Y., Wang, Y., & Chen, L. (2024) · Journal of Manufacturing Processes · doi:10.1016/j.jmapro.2024.07.100 · Cited by 19 · see citing works
Coronalin vivoforward-imaging of rat brain morphology with an ultra-small optical coherence tomography fiber probe
Xie, Y., Bonin, T., Löffler, S., Hüttmann, G., Tronnier, V. M., & Hofmann, U. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/3/555 · Cited by 19 · see citing works
A binary stiffness compliant neural microprobe
Sharafkhani, N., Long, J. M., Adams, S. D., & Kouzani, A. Z. (2023) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2023.114759 · Cited by 17 · see citing works
Development of Silicon Probe With Acute Study on In Vivo Neural Recording and Implantation Behavior Monitored by Integrated Si-Nanowire Strain Sensors
Zhang, S., Yen, S., Xiang, Z., Liao, L., Kwong, D., & Lee, C. (2015) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2015.2417678 · Cited by 17 · see citing works
Evaluation of micro-structural damage caused by needle penetration testing
Ngan‐Tillard, D., Engin, H. K., Verwaal, W., Mulder, A., Ulusay, R., & Ergüler, Z. A. (2012) · Bulletin of Engineering Geology and the Environment · doi:10.1007/s10064-012-0430-y · Cited by 17 · see citing works
Hand–tool–tissue interaction forces in neurosurgery for haptic rendering
Aggravi, M., Momi, E. D., DiMeco, F., Cardinale, F., Casaceli, G., Riva, M., Ferrigno, G., & Prattichizzo, D. (2015) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-015-1439-8 · Cited by 17 · see citing works
Advances in Implantable Microelectrode Array Insertion and Positioning
Atkinson, D., D'Souza, T. M., Rajput, J. S., Tasnim, N., Muthuswamy, J., Marvi, H., & Pancrazio, J. J. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13355 · Cited by 16 · see citing works
Ultrasonically actuated neural probes for reduced trauma and inflammation in mouse brain
Chen, P., Young, C. G., Schaffer, C. B., & Lal, A. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00438-3 · Cited by 17 · see citing works
An Intracortical Polyimide Microprobe With Piezoelectric-Based Stiffness Control
Sharafkhani, N., Orwa, J. O., Adams, S. D., Long, J. M., Lissorgues, G., Rousseau, L., & Kouzani, A. Z. (2022) · Journal of Applied Mechanics · doi:10.1115/1.4054979 · Cited by 15 · see citing works
MINRob: A Large Force-Outputting Miniature Robot Based on a Triple-Magnet System
Xiang, Y., Liu, R., Wei, Z., Wang, X., Kang, W., Wang, M., Liu, J., Liang, X., & Zhang, J. (2024) · IEEE Transactions on Robotics · doi:10.1109/tro.2024.3410096 · Cited by 15 · see citing works
A biodegradable porous silicon and polymeric hybrid probe for electrical neural signal recording
Xue, N., Wang, D., Liu, C., Ke, Z., Elia, P., Li, T., Chi, C., Cheng, Y., & Sun, J. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.06.001 · Cited by 14 · see citing works
Flexible and Soft Materials and Devices for Neural Interface
Castagnola, E., Zheng, X. S., & Cui, X. T. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_5 · Cited by 14 · see citing works
Parylene-based electrochemical-MEMS force sensor array for assessing neural probe insertion mechanics
Kim, B., Gutierrez, C. A., Gerhardt, G. A., & Meng, E. F. (2012) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/memsys.2012.6170109 · Cited by 14 · see citing works
Fabrication and mechanical characterization of long and different penetrating length neural microelectrode arrays
Goncalves, S. B., Peixoto, A. C., da Silva, A. F., & Correia, J. H. (2015) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/25/5/055014 · Cited by 14 · see citing works
Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution
Tadayon, M. A., Pavlova, I., Martyniuk, K. M., Mohanty, A., Roberts, S. P., Barbosa, F. A. S., Denny, C. A., & Lipson, M. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-29090-6 · Cited by 13 · see citing works
Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review
Zhang, S., Song, Y., Lv, S., Jing, L., Wang, M., Liu, Y., Xu, W., Jiao, P., Zhang, S., Wang, M., et al. (2025) · Cyborg and Bionic Systems · doi:10.34133/cbsystems.0249 · Cited by 15 · see citing works
Spatially Resolved Analytical Chemistry in Intact, Living Tissues
Belanger, M. C., Anbaei, P., Dunn, A. F., Kinman, A. W. L., & Pompano, R. R. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03625 · Cited by 12 · see citing works
A Pneumatic-Based Mechanism for Inserting a Flexible Microprobe Into the Brain
Sharafkhani, N., Kouzani, A. Z., Adams, S. D., Long, J. M., & Orwa, J. O. (2022) · Journal of Applied Mechanics · doi:10.1115/1.4053398 · Cited by 11 · see citing works
Detachable ultrasonic enabled inserter for neural probe insertion using biodissolvable Polyethylene Glycol
Chen, P., & Lal, A. (2015) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers.2015.7180877 · Cited by 12 · see citing works
Laser Sharpening of Carbon Fiber Microelectrode Arrays for Brain Recording
Dong, T., Chen, L., & Shih, A. J. (2020) · Journal of Micro and Nano-Manufacturing · doi:10.1115/1.4049780 · Cited by 12 · see citing works
Multi-scale measurement of stiffness in the developing ferret brain
Walter, C., Balouchzadeh, R., Garcia, K., Kroenke, C. D., Pathak, A., & Bayly, P. V. (2023) · Scientific Reports · doi:10.1038/s41598-023-47900-4 · Cited by 11 · see citing works

Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes
Obaid, A., Hanna, M.-E. S., Huang, S.-W., Hu, Y.-T., Jáidar, O., Nix, W. D., Ding, J., Melosh, N. A., & Wu, Y. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2529147123 · Cited by 28 · see citing works
Impact of Tip Size and Shape on the Insertion Force of Implantable CMOS Neural Probes
Perna, A., Ribeiro, J. F., Orbán, G., Vincenzi, M., Boi, F., Angotzi, G. N., & Berdondini, L. (2023) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner52421.2023.10123886 · Cited by 6 · see citing works
Force Measurements to Advance the Design and Implantation of CMOS-Based Neural Probes
Perna, A., Orbán, G., Berdondini, L., & Ribeiro, J. F. (2024) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2024.3519763 · Cited by 5 · see citing works
Comparative study on the insertion behavior of cerebral microprobes
Haj‐Hosseini, N., Hoffmann, R., Kisban, S., Stieglitz, T., Paul, O., & Ruther, P. (2007) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2007.4353391 · Cited by 55 · see citing works
Mechanics of Long-Shank 5 mm Neural Probe Insertion into the Rat Brain: Effects of Geometry and Vibration-Assisted Insertion
Khajehzadeh, M., Nguyen, C. K., Maharana, M., Peddapuram, S., Joshi‐Imre, A., Pascual, J. M., & Cogan, S. F. (2026) · Micromachines · doi:10.3390/mi17060684

Authors: Sharp, A. A., Ortega, A. M., Restrepo, D., Curran-Everett, D., & Gall, K.
Affiliations: Southern Illinois University Carbondale (US)
University of Colorado Boulder (US)
University of Colorado Denver (US)
Georgia Institute of Technology (US)
ORCID: Restrepo, D.
Venue: IEEE Transactions on Biomedical Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 2009-01
Volume: 56
Issue: 1
Pages: 45-53
ISSN: 0018-9294 (ISSN-L)
1558-2531
DOI: 10.1109/tbme.2008.2003261
PMC: PMC2855535
OpenAlex: W2143732412
Cited by: 157
References: 32
Citations by year: 2026: 8 · 2025: 3 · 2024: 15 · 2023: 12 · 2022: 9 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 12 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 6
FWCI: 1.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Transactions on Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Deafness and Other Communication Disorders (DC-00566, R01DC000566)
National Institute of Neurological Disorders and Stroke (NS054161, R21NS054161)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: brain tissue mechanics, probe insertion, cerebral cortex, olfactory bulb, cutting force, friction force, probe geometry, dura mater, pia mater, mouse brain, implant design
MeSH terms: Algorithms, Analysis of Variance, Animals, Biomechanical Phenomena, Brain, Cerebral Cortex, Dura Mater, Microscopy, Electron, Scanning, Olfactory Bulb, Pia Mater, Stainless Steel, Stress, Mechanical, Poisson Distribution, Prostheses and Implants, Mice, Elastic Modulus

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In Vivo Penetration Mechanics and Mechanical Properties of Mouse Brain Tissue at Micrometer Scales

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