Computer-aided continuous drug infusion: setup and test of a mobile closed-loop system for the continuous automated infusion of insulin
Abstract
For a diabetes mellitus patient, tight control of glucose level is essential. Results are reported of an investigation of the suitability of existing wearable continuous insulin infusors controlled and adjusted by a control algorithm using continuous glucose measurements as input to perform the functionality of an artificial pancreas. Special attention was given to the development of a continuous glucose monitor and to evaluate which quality of input data is necessary for the control algorithm. In clinical trials, it was found that for patients in a controlled environment an autonomously regulating control algorithm leads to an improved adjustment of patient glucose values and less overall insulin infusion as compared with the best fixed preprogrammed insulin infusion profiles of standard pump therapy. For the limited number of cases studied here, functionality of the control algorithm could tolerate some delay between the actual glucose values in the patient interstitial fluid and the algorithm input of up to 30 min. A quasicontinuous glucose measurement delivering actual glucose values every 5-10 min seems to be suited to control an artificial pancreas.
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Dudde et al. developed a minimally-invasive wearable closed-loop quasi-continuous drug infusion system that measures blood glucose levels and infuses insulin automatically.
“For example, Dudde et al. [30] developed a minimally-invasive wearable closed-loop quasi-continuous drug infusion system that measures blood glucose levels and infuses insulin automatically.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [30]
The Dudde et al. device has integrated Bluetooth communication capability for displaying and logging data and receiving commands from a personal digital assistant (PDA) device.
“The device has integrated Bluetooth communication capability for displaying and logging data and receiving commands from a personal digital assistant (PDA) device.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [30]
The glucose monitor consists of a novel silicon sensor that continuously measures glucose levels using a microperfusion technique.
“The glucose monitor consists of a novel silicon sensor that continuously measures glucose levels using a microperfusion technique and continuous infusion of insulin is achieved by a modified advanced insulin pump.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [30]
Continuous infusion of insulin in the Dudde et al. system is achieved by a modified advanced insulin pump.
“The glucose monitor consists of a novel silicon sensor that continuously measures glucose levels using a microperfusion technique and continuous infusion of insulin is achieved by a modified advanced insulin pump.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [30]
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- Authors
- Dudde, R., Vering, T., Piechotta, G., & Hintsche, R.
- Affiliations
- Fraunhofer Institute for Silicon Technology (DE)
- Venue
- IEEE Transactions on Information Technology in Biomedicine
- Published
- 2006-04
- Volume
- 10
- Issue
- 2
- Pages
- 395-402
- ISSN
- 1089-7771 (ISSN-L)
- 1558-0032
- OpenAlex
- W2152908566
- Cited by
- 47
- References
- 15
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Information Technology in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Physical Sciences › Engineering › Biomedical Engineering › Intravenous Infusion Technology and Safety
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- continuous insulin infusion, artificial pancreas, continuous glucose monitoring, diabetes mellitus, glycemic control, control algorithms, insulin dose reduction
- MeSH terms
- Algorithms, Ambulatory Care, Artificial Intelligence, Blood Glucose, Diabetes Mellitus, Drug Therapy, Computer-Assisted, Equipment Design, Feedback, Humans, Insulin, Insulin Infusion Systems, Blood Glucose Self-Monitoring, Equipment Failure Analysis
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