The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Phenol-soluble modulins – critical determinants of staphylococcal virulence
Open accessAbstract
Phenol-soluble modulins (PSMs) are a recently discovered family of amphipathic, alpha-helical peptides that have multiple roles in staphylococcal pathogenesis and contribute to a large extent to the pathogenic success of virulent staphylococci, such as Staphylococcus aureus. PSMs may cause lysis of many human cell types including leukocytes and erythrocytes, stimulate inflammatory responses, and contribute to biofilm development. PSMs appear to have an original role in the commensal lifestyle of staphylococci, where they facilitate growth and spreading on epithelial surfaces. Aggressive, cytolytic PSMs seem to have evolved from that original role and are mainly expressed in highly virulent S. aureus. Here, we will review the biochemistry, genetics, and role of PSMs in the commensal and pathogenic lifestyles of staphylococci, discuss how diversification of PSMs defines the aggressiveness of staphylococcal species, and evaluate potential avenues to target PSMs for drug development against staphylococcal infections.
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“PSMs are characterized by amphiphilicity α-helical secondary structure, which gives them surfactant-like properties [36].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [36]
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Cites
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BackgroundThe role of nasal carriage in Staphylococcus aureus infections
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Self-citationInsights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
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Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
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Cited by
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Self-citationHobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
“Discovered originally in S. epidermidis as immunomodulatory peptides, it is now well accepted that the proteins confer virulence to S. aureus (Cheung et al. 2014).”
BackgroundRegulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Quorum-sensing regulation in staphylococci—an overview
Le, K. Y., & Otto, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 490
Self-citationA Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Metadata
- Authors
- Cheung, G. Y. C., Joo, H.-S., Chatterjee, S. S., & Otto, M.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07
- Volume
- 38
- Issue
- 4
- Pages
- 698-719
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2033353380
- Cited by
- 369
- References
- 23
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- green
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