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The first 1000 cultured species of the human gastrointestinal microbiota
Open accessAbstract
The microorganisms that inhabit the human gastrointestinal tract comprise a complex ecosystem with functions that significantly contribute to our systemic metabolism and have an impact on health and disease. In line with its importance, the human gastrointestinal microbiota has been extensively studied. Despite the fact that a significant part of the intestinal microorganisms has not yet been cultured, presently over 1000 different microbial species that can reside in the human gastrointestinal tract have been identified. This review provides a systematic overview and detailed references of the total of 1057 intestinal species of Eukarya (92), Archaea (8) and Bacteria (957), based on the phylogenetic framework of their small subunit ribosomal RNA gene sequences. Moreover, it unifies knowledge about the prevalence, abundance, stability, physiology, genetics and the association with human health of these gastrointestinal microorganisms, which is currently scattered over a vast amount of literature published in the last 150 years. This detailed physiological and genetic information is expected to be instrumental in advancing our knowledge of the gastrointestinal microbiota. Moreover, it opens avenues for future comparative and functional metagenomic and other high-throughput approaches that need a systematic and physiological basis to have an impact.
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“the increase in Bacteroidetes plays an essential role in the metabolic conversions of complex sugar polymers and degradation of proteins [110].”
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Metadata
- Authors
- Rajilić-Stojanović, M., & de Vos, W. M.
- Affiliations
- University of Belgrade (RS)
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-09
- Volume
- 38
- Issue
- 5
- Pages
- 996-1047
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- PMC
- PMC4262072
- OpenAlex
- W2126295648
- Cited by
- 1,182
- References
- 375
- Citations by year
- 2026: 44 · 2025: 86 · 2024: 107 · 2023: 109 · 2022: 135 · 2021: 132 · 2020: 136 · 2019: 128 · 2018: 110 · 2017: 92 · 2016: 66 · 2015: 32 · 2014: 4
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- TechnoRep (University of Belgrade – Faculty of Technology and Metallurgy) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- FP7 Ideas: European Research Council (250172)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- intestinal microorganisms, small subunit rRNA phylogeny, archaea, microbial physiology, microbial genetics, host-microbe interactions, health and disease
- MeSH terms
- Archaea, Bacteria, Humans, Bacterial Physiological Phenomena, Gastrointestinal Tract, Biodiversity, Eukaryota
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