Isolation of a human intestinal bacterium capable of daidzein and genistein conversion
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A rod-shaped gram-positive anaerobic bacterium, strain HE8, was isolated from human feces. The isolate was able to convert the isoflavones daidzein and genistein to equol and 5-hydroxy-equol, respectively. Based on phenotypic and phylogenetic analyses, strain HE8 is described as a new species, Slackia isoflavoniconvertens.
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Elevated levels of genistein and daidzein suggest reduced dietary nutrient metabolizing bacteria in the oASD microbiota.
“Elevated levels of these metabolites suggest reduced dietary nutrient metabolizing bacteria in the oASD microbiota (Matthies et al., 2008, 2009).”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Matthies et al., 2009
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- Authors
- Matthies, A., Blaut, M., & Braune, A.
- Affiliations
- German Institute of Human Nutrition (DE)
- Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany
- Corresponding author
- Braune, Annett
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2009-03-15
- Volume
- 75
- Issue
- 6
- Pages
- 1740-1744
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC2655447
- OpenAlex
- W1992373112
- Cited by
- 161
- References
- 40
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 5
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- daidzein, genistein, equol, human gut bacteria, anaerobic Gram-positive bacteria, novel bacterial species, isoflavone metabolism, human feces
- MeSH terms
- Aerobiosis, DNA, Bacterial, DNA, Ribosomal, Feces, Humans, Isoflavones, Molecular Sequence Data, Phylogeny, RNA, Bacterial, RNA, Ribosomal, 16S, Sequence Homology, Nucleic Acid, Sequence Analysis, DNA, Genistein, Genes, rRNA, Actinobacteria, Gastrointestinal Tract, Equol
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