Cited by 165Phytoestrogen effects and researchGut microbiota and healthProbiotics and Fermented Foods

Isolation of a human intestinal bacterium capable of daidzein and genistein conversion

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Matthies, Anastasia, Blaut, Michael, Braune, Annett·2009·Applied and Environmental Microbiology

Abstract

A rod-shaped gram-positive anaerobic bacterium, strain HE8, was isolated from human feces. The isolate was able to convert the isoflavones daidzein and genistein to equol and 5-hydroxy-equol, respectively. Based on phenotypic and phylogenetic analyses, strain HE8 is described as a new species, Slackia isoflavoniconvertens.

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  1. [22]Morito, K., T. Hirose, J. Kinjo, T. Hirakawa, M. Okawa, T. Nohara, S. Ogawa, S. Inoue, M. Muramatsu, and Y. Masamune. 2001. Interaction of phytoestrogens with estrogen receptors α and β. Biol. Pharm. Bull. 24:351-356. [DOI] [PubMed] [Google Scholar]

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Authors
Matthies, A., Blaut, M., & Braune, A.
Affiliations
  • German Institute of Human Nutrition (DE)
  • Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany
Corresponding author
Braune, Annett
Venue
Applied and Environmental Microbiology
Published
2009-03-15
Volume
75
Issue
6
Pages
1740-1744
ISSN
  • 0099-2240 (ISSN-L)
  • 1098-5336
OpenAlex
W1992373112
Cited by
161
References
40
Citations by year
2026: 6 · 2025: 2 · 2024: 12 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 5
FWCI
5.40
Type
journal article
Language
en
Open access
Locations
  • Applied and Environmental Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
daidzein, genistein, equol, human gut bacteria, anaerobic Gram-positive bacteria, novel bacterial species, isoflavone metabolism, human feces
MeSH terms
Aerobiosis, DNA, Bacterial, DNA, Ribosomal, Feces, Humans, Isoflavones, Molecular Sequence Data, Phylogeny, RNA, Bacterial, RNA, Ribosomal, 16S, Sequence Homology, Nucleic Acid, Sequence Analysis, DNA, Genistein, Genes, rRNA, Actinobacteria, Gastrointestinal Tract, Equol

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