Different Flavonoids Can Shape Unique Gut Microbiota Profile In Vitro
Abstract
The impact of flavonoids has been discussed on the relative viability of bacterial groups in human microbiota. This study was aimed to compare the modulation of various flavonoids, including quercetin, catechin and puerarin, on gut microbiota culture in vitro, and analyze the interactions between bacterial species using fructo-oligosaccharide (FOS) as carbon source under the stress of flavonoids. Three plant flavonoids, quercetin, catechin, and puerarin, were added into multispecies culture to ferment for 24 h, respectively. The bacterial 16S rDNA amplicons were sequenced, and the composition of microbiota community was analyzed. The results revealed that the tested flavonoids, quercetin, catechin, and puerarin, presented different activities of regulating gut microbiota; flavonoid aglycones, but not glycosides, may inhibit growth of certain species. Quercetin and catechin shaped unique biological webs. Bifidobacterium spp. was the center of the biological web constructed in this study.
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Some flavonoids, such as quercetin, resveratrol, and catechin, can regulate the gut microbiota in animal models.
“The ability of some flavonoids, such as quercetin, resveratrol, and catechin, to regulate the gut microbiota has been documented in animal models (25–27).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [27]
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- Authors
- Huang, J., Chen, L., Xue, B., Liu, Q., Ou, S., Wang, Y., & Peng, X.
- Affiliations
- Jinan University (CN)
- Corresponding author
- Peng, Xichun
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2016-07-29
- Volume
- 81
- Issue
- 9
- Pages
- H2273-9
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2483302157
- Cited by
- 52
- References
- 37
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 12 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Food Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science (31471589)
- Central Universities (21615404)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- flavonoids, gut microbiota, quercetin, catechins, puerarin, fructooligosaccharides, bacterial community composition, bacterial interactions, Bifidobacterium, flavonoid aglycones, bacterial growth inhibition
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium, Catechin, Flavonoids, Glycosides, Humans, Isoflavones, Oligosaccharides, Plant Extracts, Quercetin, RNA, Ribosomal, 16S, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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