The DOI matches its Crossref record; 97 of the 98 references it cites were found in a registry or an index.
Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties
Abstract
Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein‐derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide‐based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large‐scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.
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“For instance, a novel peptide (GIVAGDVTPI) derived from Limnospira platensis was shown to promote endothelial nitric oxide (NO) production via activation of the PI3K/AKT pathway, leading to vasorelaxation and improved serum nitrite levels in vivo [68].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [68]
Citations
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Trends in Microalgae Incorporation Into Innovative Food Products With Potential Health Benefits
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Metadata
- Authors
- Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W.
- Affiliations
- Jiangnan University (CN)
- Corresponding author
- Yang, Ruijin
- Zhao, Wei
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2017-12-11
- Volume
- 83
- Issue
- 1
- Pages
- 6-16
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2774714865
- Cited by
- 293
- References
- 98
- Citations by year
- 2026: 25 · 2025: 27 · 2024: 45 · 2023: 46 · 2022: 52 · 2021: 42 · 2020: 31 · 2019: 17 · 2018: 8
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Food Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31522044)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- bioactive peptides, seaweed proteins, antihypertensive peptides, antioxidant peptides, antidiabetic peptides, angiotensin-converting enzyme inhibition, hypertension, diabetes mellitus, oxidative stress, cardiovascular disease prevention, functional foods, peptide isolation, sustainable protein sources
- MeSH terms
- Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypertension, Hypoglycemic Agents, Peptides, Seaweed, Functional Food
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