Cited by 293Protein Hydrolysis and Bioactive PeptidesSeaweed-derived Bioactive CompoundsProteins in Food Systems

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Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

Admassu, Habtamu, Gasmalla, Mohammed Abdalbasit. A., Yang, Ruijin, Zhao, Wei·2018·Journal of Food Science

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Abstract

Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein‐derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide‐based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large‐scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.

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Authors: Admassu, H., Gasmalla, M. A. A., Yang, R., & Zhao, W.
Affiliations: Jiangnan University (CN)
Corresponding author: Yang, Ruijin
Zhao, Wei
ORCID: Admassu, Habtamu
Gasmalla, Mohammed Abdalbasit. A.
Yang, Ruijin
Zhao, Wei
Venue: Journal of Food Science
Publisher: Wiley
Published: 2017-12-11
Volume: 83
Issue: 1
Pages: 6-16
ISSN: 0022-1147 (ISSN-L)
1750-3841
DOI: 10.1111/1750-3841.14011
OpenAlex: W2774714865
Cited by: 293
References: 98
Citations by year: 2026: 25 · 2025: 27 · 2024: 45 · 2023: 46 · 2022: 52 · 2021: 42 · 2020: 31 · 2019: 17 · 2018: 8
FWCI: 1.43
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Food Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31522044)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords: bioactive peptides, seaweed proteins, antihypertensive peptides, antioxidant peptides, antidiabetic peptides, angiotensin-converting enzyme inhibition, hypertension, diabetes mellitus, oxidative stress, cardiovascular disease prevention, functional foods, peptide isolation, sustainable protein sources
MeSH terms: Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypertension, Hypoglycemic Agents, Peptides, Seaweed, Functional Food

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Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

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