IGF‐I regulates the age‐dependent signaling peptide humanin
Open accessAbstract
Aging is influenced by endocrine pathways including the growth hormone/insulin-like growth factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging process, but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood. Humanin is a novel signaling peptide that acts as a potent regulator of cellular stress responses and protects from a variety of in vitro and in vivo toxic and metabolic insults. The circulating levels of humanin decline with age in mice and humans. Here, we demonstrate a negative correlation between the activity of the GH-IGF axis and the levels of humanin, as well as a positive correlation between humanin and lifespan in mouse models with altered GH/IGF-I axis. Long-lived, GH-deficient Ames mice displayed elevated humanin levels, while short-lived GH-transgenic mice have reduced humanin levels. Furthermore, treatment with GH or IGF-I reduced circulating humanin levels in both mice and human subjects. Our results indicate that GH and IGF are potent regulators of humanin levels and that humanin levels correlate with lifespan in mice. This suggests that humanin represents a circulating mitochondrial signal that participates in modulating the aging process, adding a coordinated mitochondrial element to the endocrine regulation of aging.
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IGF-1 inhibits the production of HN.
“and that IGF-1 inhibits the production of HN (38).”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [38]
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- Authors
- Lee, C., Wan, J., Miyazaki, B., Fang, Y., Guevara‐Aguirre, J., Yen, K., Longo, V., Bartke, A., & Cohen, P.
- Affiliations
- University of Southern California (US)
- Children's Hospital Los Angeles (US)
- SIU Medicine (US)
- Universidad San Francisco de Quito (EC)
- Corresponding author
- Cohen, Pinchas
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2014-07-18
- Volume
- 13
- Issue
- 5
- Pages
- 958-961
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC4172517
- OpenAlex
- W2082773128
- Cited by
- 80
- References
- 18
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 2 · 2014: 1
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greater South Information System
- Funders
- NIH Office of the Director (1R01GM090311)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- humanin, insulin-like growth factor I, growth hormone, somatotropic axis, aging, lifespan, mitochondrial signaling, cellular stress response
- MeSH terms
- Age Factors, Animals, Humans, Insulin-Like Growth Factor I, Male, Mice, Inbred C57BL, Growth Hormone, Models, Animal, Intracellular Signaling Peptides and Proteins, Mice
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