Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension
Open accessAbstract
Background Autophagy, a highly conserved homeostatic mechanism, is essential for cell survival. The decline of autophagy function has been implicated in various diseases as well as aging. Although mitochondria play a key role in the autophagy process, whether mitochondrial-derived peptides are involved in this process has not been explored.Methods We developed a high through put screening method to identify potential autophagy inducers among mitochondrial-derived peptides. We used three different cell lines, mice, c.elegans, and a human cohort to validate the observation.Results Humanin, a mitochondrial-derived peptide, increases autophagy and maintains autophagy flux in several cell types. Humanin administration increases the expression of autophagy-related genes and lowers accumulation of harmful misfolded proteins in mice skeletal muscle, suggesting that humanin-induced autophagy potentially contributes to the improved skeletal function. Moreover, autophagy is a critical role in humanin-induced lifespan extension in C. elegans.Conclusions Humanin is an autophagy inducer.General significance This paper presents a significant, novel discovery regarding the role of the mitochondrial derived peptide humanin in autophagy regulation and as a possible therapeutic target for autophagy in various age-related diseases.
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Humanin administration promotes autophagy and reduces accumulation of abnormal proteins by activating AMPK upstream of PI3K Class III complex formation, enhancing skeletal muscle health and function.
“Humanin administration promotes autophagy and reduces the accumulation of abnormal proteins by activating AMPK upstream of PI3K Class III complex formation, thereby enhancing skeletal muscle health and function [26].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [26]
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- Authors
- Kim, S.-J., Devgan, A., Miller, B., Lee, S. M., Kumagai, H., Wilson, K. A., Wassef, G., Wong, R., Mehta, H. H., Cohen, P., & Yen, K.
- Affiliations
- University of Southern California (US)
- Buck Institute for Research on Aging (US)
- Corresponding author
- Cohen, Pinchas
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 1866
- Issue
- 1
- Pages
- 130017
- ISSN
- 0304-4165 (ISSN-L)
- PMC
- PMC8595716
- OpenAlex
- W3202994840
- Cited by
- 30
- References
- 62
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 4 · 2021: 1
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (3P01AG055369, 5R01AG068405, R01AG069698, RF1AG061834)
- AFAR
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- humanin, autophagy, mitochondrial peptides, skeletal muscle function, lifespan extension, aging, autophagic flux, misfolded protein accumulation, exercise capacity, autophagy-related genes, age-related diseases, Caenorhabditis elegans, siRNA knockdown
- MeSH terms
- Aging, Animals, Autophagy, Cell Line, Cell Survival, Homeostasis, Humans, Longevity, Male, Mice, Inbred C57BL, Mitochondria, Peptides, Caenorhabditis elegans, Muscle, Skeletal, Intracellular Signaling Peptides and Proteins, Mice, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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