The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging
Open accessAbstract
Summary: Female reproductive capacity declines dramatically in the fourth decade of life as a result of an age‐related decrease in oocyte quality and quantity. The primary causes of reproductive aging and the molecular factors responsible for decreased oocyte quality remain elusive. Here, we show that aging of the female germ line is accompanied by mitochondrial dysfunction associated with decreased oxidative phosphorylation and reduced Adenosine tri‐phosphate (ATP) level. Diminished expression of the enzymes responsible for CoQ production, Pdss2 and Coq6, was observed in oocytes of older females in both mouse and human. The age‐related decline in oocyte quality and quantity could be reversed by the administration of CoQ10. Oocyte‐specific disruption of Pdss2 recapitulated many of the mitochondrial and reproductive phenotypes observed in the old females including reduced ATP production and increased meiotic spindle abnormalities, resulting in infertility. Ovarian reserve in the oocyte‐specific Pdss2‐deficient animals was diminished, leading to premature ovarian failure which could be prevented by maternal dietary administration of CoQ10. We conclude that impaired mitochondrial performance created by suboptimal CoQ10 availability can drive age‐associated oocyte deficits causing infertility.
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Cites
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Cited by
Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
Stefely, J. A., & Pagliarini, D. J. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.06.008 · Cited by 331
Mechanisms of oocyte aneuploidy associated with advanced maternal age
Mikwar, M., MacFarlane, A. J., & Marchetti, F. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108320 · Cited by 308
Wang, Y., & Hekimi, S. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.007 · Cited by 256
Secomandi, L., Borghesan, M., Velarde, M., & Demaria, M. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmab038 · Cited by 208
Aging and the environment affect gamete and embryo potential: can we intervene?
Meldrum, D. R., Casper, R. F., Diez-Juan, A., Simon, C., Domar, A. D., & Frydman, R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.01.013 · Cited by 159
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Metadata
- Authors
- Ben‐Meir, A., Burstein, E., Borrego‐Alvarez, A., Chong, J., Wong, E., Yavorska, T., Naranian, T., Chi, M., Wang, Y., Bentov, Y., Alexis, J., Meriano, J., Sung, H., Gasser, D. L., Moley, K. H., Hekimi, S., Casper, R. F., & Jurisicova, A.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2015-06-26
- Volume
- 14
- Issue
- 5
- Pages
- 887-895
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1949822692
- Cited by
- 469
- References
- 40
- FWCI
- 29.12
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ben‐Meir, A., Burstein, E., Borrego‐Alvarez, A., Chong, J., Wong, E., Yavorska, T., Naranian, T., Chi, M., Wang, Y., Bentov, Y., Alexis, J., Meriano, J., Sung, H., Gasser, D. L., Moley, K. H., Hekimi, S., Casper, R. F., & Jurisicova, A. (2015). Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. https://doi.org/10.1111/acel.12368
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