Cited by 150Selenium in Biological SystemsOrganoselenium and organotellurium chemistryAntioxidant Activity and Oxidative Stress

Selenium, aging and aging-related diseases

Cai, Zhonglin, Zhang, Jianzhong, Li, Hongjun·2019·Aging Clinical and Experimental Research

Abstract

Selenium is an essential trace element in the human body and plays an important role in the body via selenoprotein, which contains selenium. Selenoproteins (glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase1 and endoplasmic reticulum-selenoproteins, etc.) have antioxidant effects and are involved in regulating antioxidant activities. Aging is an inevitable process and is always accompanied by aging-related diseases. Reactive oxygen species are important initial factors in aging and aging-related diseases. Selenium contributes to the alleviation of reduced reactive oxygen species-mediated inflammation, reduced DNA damage and prolonged telomere length and thereby plays roles in fighting aging and preventing aging-related diseases. In the elderly, aging-related diseases include neuropsychiatric diseases, tumors, cardiovascular diseases, and skin aging, among others. Selenium supplementation is an important strategy for anti-aging and the prevention of aging-related diseases and is of great significance for the elderly. However, with the accumulation of related research, selenium supplementation does not necessarily contribute to the prevention of aging and aging-related diseases. It is believed that a low level of selenium is beneficial to the human body. Thus, the effect of selenium on human aging and aging-related diseases is still controversial. This paper reviews the research progress and objective role of selenium in aging and aging-related diseases.

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Crossref · 10.1007/s40520-018-1086-7

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134 of 134 references verified0 citation errors · 0 not checkable

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  • Selenium supplementation is an important strategy for inhibiting wrinkles because it can reverse ultraviolet light damage and play an anti-ageing role in the skin.

    “Selenium supplementation is an important strategy for inhibiting wrinkles, because it can reverse ultraviolet light damage and play an anti-ageing role in the skin [89,92].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]

  • Selenium exhibits strong antioxidant properties and protects against DNA damage.

    “Selenium exhibits strong antioxidant properties and protects against DNA damage [88,89].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]

  • Selenium is important for skin function, having a protective effect and the ability to scavenge free radicals.

    “The mineral is also important for skin function, having a protective effect and the ability to scavenge free radicals [89].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [89]

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Authors
Cai, Z., Zhang, J., & Li, H.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
Li, Hongjun
Venue
Aging Clinical and Experimental Research
Published
2018-12-03
Volume
31
Issue
8
Pages
1035-1047
ISSN
  • 1594-0667 (ISSN-L)
  • 1720-8319
OpenAlex
W2902968311
Cited by
150
References
134
Citations by year
2026: 7 · 2025: 15 · 2024: 28 · 2023: 25 · 2022: 32 · 2021: 18 · 2020: 16 · 2019: 9
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Aging Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
selenium, aging, age-related diseases, selenoproteins, glutathione peroxidase, thioredoxin reductase, methionine sulfoxide reductase, reactive oxygen species, antioxidant activity, telomere length, DNA damage, inflammation, selenium supplementation, skin aging, cardiovascular disease, cancer prevention, neuropsychiatric disorders
MeSH terms
Aging, Animals, DNA Damage, Glutathione Peroxidase, Humans, Selenium, Reactive Oxygen Species

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