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The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Senescent cells and the incidence of age‐related diseases

Katzir, Itay, Adler, Miri, Karin, Omer, Mendelsohn‐Cohen, Netta, Mayo, Avi, Alon, Uri·2021·Aging Cell
DOI 10.1111/acel.13314PMC PMC7963340
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Abstract

Age‐related diseases such as cancer, cardiovascular disease, kidney failure, and osteoarthritis have universal features: Their incidence rises exponentially with age with a slope of 6–8% per year and decreases at very old ages. There is no conceptual model which explains these features in so many diverse diseases in terms of a single shared biological factor. Here, we develop such a model, and test it using a nationwide medical record dataset on the incidence of nearly 1000 diseases over 50 million life‐years, which we provide as a resource. The model explains incidence using the accumulation of senescent cells, damaged cells that cause inflammation and reduce regeneration, whose level rise stochastically with age. The exponential rise and late drop in incidence are captured by two parameters for each disease: the susceptible fraction of the population and the threshold concentration of senescent cells that causes disease onset. We propose a physiological mechanism for the threshold concentration for several disease classes, including an etiology for diseases of unknown origin such as idiopathic pulmonary fibrosis and osteoarthritis. The model can be used to design optimal treatments that remove senescent cells, suggeting that treatment starting at old age can sharply reduce the incidence of all age‐related diseases, and thus increase the healthspan.

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Metadata

Authors
Katzir, I., Adler, M., Karin, O., Mendelsohn‐Cohen, N., Mayo, A., & Alon, U.
Affiliations
  • Department of Molecular Cell Biology Weizmann Institute of Science Rehovot Israel
  • Department of Computer Science Weizmann Institute of Science Rehovot Israel
ORCID
Venue
Aging Cell
Publisher
Wiley
Published
2021-02-08
Volume
20
Issue
3
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1111/acel.13314
PMC
PMC7963340
Cited by
85
References
30
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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