Acute alcohol response phenotype in heavy social drinkers is robust and reproducible
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BACKGROUND: In 3 previously published works (Brumback et al., 2007, Drug Alcohol Depend 91:10-17; King et al., 2011a, Arch Gen Psychiatry 68:389-399; Roche and King, 2010, Psychopharmacology (Berl) 212:33-44), our group characterized acute alcohol responses in a large group of young, heavy binge drinkers (n = 104) across a variety of subjective, eye-tracking, and psychometric performance measures. METHODS: The primary goal of the current study was to directly replicate prior findings of alcohol response in heavy social drinkers (HD) in a second independent cohort (n = 104) using identical methodology. A secondary goal was to examine the effects of family history (FH) of alcohol use disorders (AUD) on acute alcohol response in both samples. Participants attended 2 randomized laboratory sessions in which they consumed 0.8 g/kg alcohol or a taste-masked placebo. At pre- and post-drink time points, participants completed subjective scales, psychomotor performance and eye-movement tasks, and provided salivary samples for cortisol determination. RESULTS: Results showed that the second cohort of heavy drinkers exhibited a nearly identical pattern of alcohol responses to the original cohort, including sensitivity to alcohol's stimulating and hedonically rewarding effects during the rising breath alcohol content (BrAC) limb, increases in sedation during the declining BrAC limb, a lack of cortisol response, and psychomotor and eye-tracking impairment that was most evident at peak BrAC. The magnitude and temporal pattern of these acute effects of alcohol in the second cohort were similar to the first cohort across all measures, with the exception of 3 eye-movement measures: pro- and antisaccade accuracy and antisaccade velocity. FH of AUD did not affect alcohol response in the first cohort, and this was replicated in the second cohort. CONCLUSIONS: In sum, in 2 independent samples, we have demonstrated that HD display a consistent and reliable sensitivity to alcohol's subjective effects and impairment of eye-tracking and psychomotor performance, which is not affected by FH status. This acute alcohol response phenotype in heavy, frequent binge drinkers appears to be robust and reproducible.
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These findings were replicated in a second independent heavy drinker cohort using identical procedures.
“These findings were replicated in a second independent heavy drinker cohort using identical procedures(33).”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [33]
The results support prior work showing high alcohol-induced stimulation, reward, and craving in heavy drinkers or alcoholics as well as low alcohol-induced sedation and cortisol in other at-risk drinkers.
“The results support prior work showing high alcohol-induced stimulation, reward, and craving in heavy drinkers or alcoholics(33, 79, 80) as well as low alcohol-induced sedation and cortisol in other at-risk drinkers(81).”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [33]
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
(1970) · Cited by 24,983 · see citing works
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
Raise standards for preclinical cancer research
Begley, C. G., & Ellis, L. M. (2012) · Nature · doi:10.1038/483531a · Cited by 2,979 · cited 3× · see citing works
“…failures to replicate in the medical field, with only 11% of high-impact findings in preclinical cancer research successfully replicated, there has been a renewed focus on the importance of reproducibility of novel and influential results in various fields of science (Begley and Ellis, 2012).”
BackgroundThe Family History Method Using Diagnostic Criteria
Andreasen, N. C. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770220111013 · Cited by 1,903 · see citing works
Believe it or not: how much can we rely on published data on potential drug targets?
Prinz, F., Schlange, T., & Asadullah, K. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3439-c1 · Cited by 1,888 · see citing works
Nosek (2012) · doi:10.1177/1745691612459058 · Cited by 1,301 · see citing works
Shall we Really do it Again? The Powerful Concept of Replication is Neglected in the Social Sciences
Schmidt, S. (2009) · Review of General Psychology · doi:10.1037/a0015108 · Cited by 1,125 · see citing works
Replications in Psychology Research: How Often Do They Really Occur?
Makel, M. C., Plucker, J. A., & Hegarty, B. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612460688 · Cited by 750 · see citing works
Reliability of alcohol abusers' self-reports of drinking behavior
Sobell, L. C., Maisto, S. A., Sobell, M. B., & Cooper, A. M. (1979) · Behaviour Research and Therapy · doi:10.1016/0005-7967(79)90025-1 · Cited by 721 · see citing works
Is the Replicability Crisis Overblown? Three Arguments Examined
Pashler, H., & Harris, C. R. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612463401 · Cited by 697 · see citing works
Development and Validation of the Biphasic Alcohol Effects Scale
Martin, C. S., Earleywine, M., Musty, R. E., Perrine, M. W., & Swift, R. M. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00739.x · Cited by 683 · see citing works
An 8-year follow-up of 450 sons of alcoholic and control subjects
Schuckit, M. A. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830030020005 · Cited by 627 · see citing works
An Open, Large-Scale, Collaborative Effort to Estimate the Reproducibility of Psychological Science
Open Science Collaboration (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612462588 · Cited by 605 · see citing works
Alcohol challenge with sons of alcoholics: A critical review and analysis.
Newlin, D. B., & Thomson, J. B. (1990) · Psychological Bulletin · doi:10.1037/0033-2909.108.3.383 · Cited by 493 · see citing works
Helping patients who drinks too much. A Clinician’s Guide
Agabio, R., Fantozzi, F., & Tossicodipendenze, C. E. D. R. M. D. (2006) · UNICA IRIS Institutional Research Information System (University of Cagliari) · Cited by 392 · see citing works
Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking
King, A. C., de Wit, H., McNamara, P. J., & Cao, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.26 · Cited by 379 · see citing works
Self-citationKoole, S. L., & Lakens, D. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612462586 · Cited by 281 · see citing works
The drug effects questionnaire: psychometric support across three drug types
Morean, M. E., de Wit, H., King, A. C., Sofuoglu, M., Rueger, S. Y., & O’Malley, S. S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2954-z · Cited by 252 · see citing works
Self-citationSelf-rating of alcohol intoxication by young men with and without family histories of alcoholism.
Schuckit, M. A. (1980) · Journal of Studies on Alcohol · doi:10.15288/jsa.1980.41.242 · Cited by 251 · see citing works
Subjective Response to Alcohol Challenge: A Quantitative Review
Quinn, P. D., & Fromme, K. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01521.x · Cited by 245 · see citing works
Drug preference and mood in humans: Diazepam
Johanson, C. E., & UHLENHUTH, E. H. (1980) · Psychopharmacology · doi:10.1007/bf00433061 · Cited by 211 · see citing works
Alcohol challenge responses predict future alcohol use disorder symptoms: A 6-year prospective study
King, A. C., McNamara, P. J., Hasin, D. S., & Cao, D. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.001 · Cited by 205 · see citing works
Misuse of statistical tests in three decades of psychotherapy research.
Dar, R., Serlin, R. C., & Omer, H. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.62.1.75 · Cited by 152 · see citing works
Brumback, T., Cao, D., & King, A. C. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.04.013 · Cited by 140 · see citing works
Self-citationMisuse of statistical tests in three decades of psychotherapy research.
Dar, R., Serlin, R. C., & Omer, H. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.1.75 · Cited by 109 · see citing works
Psychology’s Woes and a Partial Cure: The Value of Replication
Roediger, H. L., III (2012) · APS observer · Cited by 101 · see citing works
Catching the Alcohol Buzz: An Examination of the Latent Factor Structure of Subjective Intoxication
Ray, L. A., MacKillop, J., Leventhal, A. M., & Hutchison, K. E. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01053.x · Cited by 94 · see citing works
Newlin, D. B., & Thomson, J. B. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.7.3.234 · Cited by 78 · see citing works
Newlin, D. B., & Thomson, J. B. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.7.3.234 · Cited by 78 · see citing works
Newlin, D. B., & Renton, R. M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01081.x · Cited by 72 · see citing works
The effect of oral ethanol consumption on eye movements in healthy volunteers
Moser, A., Heide, W., & Kömpf, D. (1998) · Journal of Neurology · doi:10.1007/s004150050240 · Cited by 65 · see citing works
Acute effects of alcohol on saccadic eye movements
Lehtinen, I., Lang, A. H., J�ntti, V., et al. (1979) · Psychopharmacology · doi:10.1007/bf00426915 · Cited by 51 · see citing works
Roche, D. J. O., & King, A. C. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1906-8 · Cited by 51 · see citing works
Self-citationEthnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans
Duranceaux, N. C. E., Schuckit, M. A., Luczak, S. E., et al. (2008) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2008.69.227 · Cited by 45 · see citing works
Blekher, T., Ramchandani, V. A., Wetherill, L. F., Foroud, T., Kareken, D. A., Yee, R. D., Li, T., & O’Connor, S. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02457.x · Cited by 40 · see citing works
Vorstius, C., Radach, R. R., Lang, A. R., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0954-1 · Cited by 35 · see citing works
Conrad, M., McNamara, P., & King, A. (2012) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0029261 · Cited by 32 · see citing works
Kerfoot, K. E., Pittman, B. P., Ralevski, E., Limoncelli, D., Koretski, J. A., Newcomb, J., Arias, A. J., & Petrakis, I. L. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12199 · Cited by 30 · see citing works
Blekher, T., Beard, J. D., O’Connor, S., et al. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02529.x · Cited by 29 · see citing works
Thomas, S. E., Drobes, D. J., Voronin, K., & Anton, R. F. (2004) · Journal of Studies on Alcohol · doi:10.15288/jsa.2004.65.330 · Cited by 27 · see citing works
Subjective Responses to Alcohol: A Paradigm Shift May Be Brewing
King, A. C., Roche, D., & Rueger, S. Y. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01629.x · Cited by 26 · see citing works
Self-citationSchuckit, M. A., Smith, T. L., & Kalmijn, J. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000141814.80716.32 · Cited by 22 · see citing works
Corbin, W. R., Scott, C., Leeman, R. F., Fucito, L. M., Toll, B. A., & O'Malley, S. S. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01956.x · Cited by 18 · see citing works
Ethanol effects on volitional versus reflexive saccades
Vassallo, S., & Abel, L. A. (2002) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2002.00518.x · Cited by 18 · see citing works
Schuckit, M. A. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01561.x · Cited by 6 · see citing works
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Self-citationMcCaul, M. E., Wand, G. S., Weerts, E. M., & Xu, X. (2018) · Addiction Biology · doi:10.1111/adb.12511 · Cited by 23 · see citing works
- Authors
- Roche, D. J. O., Palmeri, M. D., & King, A. C.
- Affiliations
- University of California, Los Angeles (US)
- University of Chicago (US)
- Corresponding author
- King, Andrea C.
- ORCID
- King, Andrea C.
- Venue
- Alcoholism Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2013-10-07
- Volume
- 38
- Issue
- 3
- Pages
- 844-852
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC4167376
- OpenAlex
- W2018829336
- Cited by
- 39
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA013746)
- National Cancer Institute (P30‐CA14599, P30CA014599)
- National Center for Research Resources (UL1RR024999)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- binge drinking, replication, family history of alcoholism, subjective effects of alcohol, eye movements, psychomotor performance, salivary cortisol
- MeSH terms
- Adult, Ethanol, Breath Tests, Central Nervous System Depressants, Female, Humans, Hydrocortisone, Male, Phenotype, Psychomotor Performance, Pursuit, Smooth, Saccades, Saliva, Cohort Studies, Young Adult, Binge Drinking
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