Alcohol challenge responses predict future alcohol use disorder symptoms: A 6-year prospective study
Open accessAbstract
Background Propensity for alcohol misuse may be linked to an individuals' response to alcohol. This study examined the role of alcohol response phenotypes to future drinking problems.Methods One hundred four young heavy social drinkers participated in a within-subject, double-blind, placebo-controlled laboratory alcohol challenge study with 6-year follow-up. Participants were examined for subjective responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beverage, given in random order. Follow-up was conducted in 5 waves over 6 years after the sessions to assess drinking behaviors and alcohol use disorder (AUD) symptoms. Retention was high with 98% (509 of 520) of possible follow-ups completed.Results Greater sensitivity to alcohol, in terms of stimulation and rewarding effects (like, want more) and lower sensitivity to alcohol sedation predicted greater number of AUD symptoms through 6 years of follow-up. Cluster analyses revealed that for half the sample, increasing levels of stimulation and liking were predictors of more AUD symptoms with the other half divided between those showing like and want more and want more alone as significant predictors.Conclusions The findings extend previous findings and offer new empirical insights into the propensity for excessive drinking and alcohol problems. Heightened alcohol stimulation and reward sensitivity robustly predicted more alcohol use disorder symptoms over time associated with greater binge-drinking frequency. These drinking problems were maintained and progressed as these participants were entering their third decade of life, a developmental interval when continued alcohol misuse becomes more deviant.
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Greater stimulation and reward predicted more AUD symptoms experienced through six years.
“with greater stimulation and reward predicting more AUD symptoms experienced through six years(34).”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [34]
Prior report indicated that the HD and LD continued to differ significantly through follow-up on all measures of alcohol drinking behaviors and problems.
“Our prior report (King et al., 2014(34)) indicated that the HD and LD continued to differ significantly through follow-up on all measures of alcohol drinking behaviors and problems.”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as King et al., 2014
Prior report indicated that the HD and LD continued to differ significantly through follow-up on all measures of alcohol drinking behaviors and problems.
“Our prior report (King et al., 2014(34)) indicated that the HD and LD continued to differ significantly through follow-up on all measures of alcohol drinking behaviors and problems.”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [34]
The LD largely continued with low-risk drinking; while they consumed alcohol more frequently over time, binge drinking and alcohol problems were rare, and they formed one low-risk trajectory group.
“In brief, the LD largely continued with low-risk drinking. While they consumed alcohol more frequently over time, binge drinking and alcohol problems were rare, and they formed one low-risk trajectory group(34).”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [34]
These sustained pleasurable effects may increase the drive for excessive drinking despite mounting consequences and alcohol problems.
“These sustained pleasurable effects may increase the drive for excessive drinking(34) despite mounting consequences and alcohol problems.”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [34]
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- Authors
- King, A. C., McNamara, P. J., Hasin, D. S., & Cao, D.
- Affiliations
- University of Chicago (US)
- Columbia University (US)
- University of Illinois Chicago (US)
- Corresponding author
- King, Andrea C.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 75
- Issue
- 10
- Pages
- 798-806
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4280017
- OpenAlex
- W2083767842
- Cited by
- 205
- References
- 64
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 7 · 2023: 18 · 2022: 16 · 2021: 15 · 2020: 16 · 2019: 23 · 2018: 13 · 2017: 14 · 2016: 23 · 2015: 18 · 2014: 7 · 2013: 1
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000430)
- National Institute on Alcohol Abuse and Alcoholism (R01AA013746, K05AA014223)
- National Cancer Institute (P30‐CA14599, P30CA014599)
- National Center for Research Resources (UL1RR024999)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcohol challenge, alcohol use disorder symptoms, alcohol sensitivity, alcohol reward, binge drinking, young adults
- MeSH terms
- Adult, Alcohol Drinking, Ethanol, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Reward, Risk Factors, Alcohol-Related Disorders, Young Adult, Binge Drinking
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