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Cited by 136Bipolar Disorder and TreatmentMindfulness and Compassion InterventionsPersonality Disorders and Psychopathology

A randomized controlled trial of mindfulness‐based cognitive therapy for bipolar disorder

Open access
Perich, T., Manicavasagar, V., Mitchell, P. B., Ball, J. R., Hadzi‐Pavlovic, D.·2013·Acta Psychiatrica Scandinavica
DOI 10.1111/acps.12033
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Abstract

Objective: To compare the efficacy of mindfulness‐based cognitive therapy (MBCT) plus treatment as usual (TAU) to TAU alone for patients with bipolar disorder over a 12‐month follow‐up period. Method: Participants with a DSM‐IV diagnosis of bipolar disorder were randomly allocated to either MBCT plus TAU or TAU alone. Primary outcome measures were time to recurrence of a DSM‐IV major depressive, hypomanic or manic episode; the M ontgomery‐Å sberg D epression R ating S cale (MADRS); and Y oung M ania R ating S cale (YMRS). Secondary outcome measures were number of recurrences, the D epression A nxiety S tress S cales (DASS), and the S tate T rait A nxiety I nventory (STAI). Results: Ninety‐five participants with bipolar disorder were recruited to the study (MBCT = 48; TAU = 47). Intention‐to‐treat (ITT) analysis found no significant differences between the groups on either time to first recurrence of a mood episode or total number of recurrences over the 12‐month period. Furthermore, there were no significant between‐group differences on the MADRS or YMRS scales. A significant between‐group difference was found in STAI – state anxiety scores. There was a significant treatment by time interaction for the DAS – achievement subscale. Conclusion: While MBCT did not lead to significant reductions in time to depressive or hypo/manic relapse, total number of episodes, or mood symptom severity at 12‐month follow‐up, there was some evidence for an effect on anxiety symptoms. This finding suggests a potential role of MBCT in reducing anxiety comorbid with bipolar disorder.

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Crossref · 10.1111/acps.12033

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  • One RCT of MBCT involving 95 patients did not demonstrate any difference in relapse prevention compared to treatment as usual, but did reveal fewer anxiety and depressive symptoms in the MBCT arm.

    “One RCT of MBCT involving 95 patients did not demonstrate any difference in relapse prevention compared to a treatment‐as‐usual group, but did reveal fewer anxiety and depressive symptoms in the MBCT arm.115”

    From Canadian Network for Mood and Anxiety Treatments ( <scp>CANMAT</scp> ) and International Society for Bipolar Disorders ( <scp>ISBD</scp> ) 2018 guidelines for the management of patients with bipolar disorder (2018) · cites this paper as [115]

    The Results (p. 6) report that 95 patients were randomized, and the Results (p. 7) found no significant difference in relapse between MBCT and treatment as usual. The Discussion (p. 9) reports lower state-anxiety scores in the MBCT group, but no significant treatment effect on depressive scores over 12 months. The claim's assertion of fewer depressive symptoms is therefore unsupported. (LLM, conf=0.94)

    Experimental — accuracy not yet measured

  • One of the few studies with 12-month follow-up found that MBI did not prevent relapse or depressive symptomatology compared with the control group.

    “One of the few studies with 12-month follow-up (Perich et al., 2013) found that MBI did not prevent relapse or depressive symptomatology compared with the control group.”

    From Analysis of the Efficacy of Mindfulness Meditation in a Mutual Aid Group for Bipolar Disorder (2024) · cites this paper as Perich et al., 2013

  • Mindfulness may help to prevent relapse into addiction by interrupting the automaticity of substance use in response to triggers and by reducing unhelpful attention biases and memory responses to triggers.

    “Mindfulness may help to prevent relapse into addiction by interrupting the automaticity of substance use in response to triggers and by reducing unhelpful attention biases and memory responses to triggers.19”

    From Mindfulness in psychiatry - Where are we now? (2016) · cites this paper as [19]

    The Introduction (p. 2) discusses mindfulness-based cognitive therapy for preventing depressive relapse, and the Results (p. 7) address relapse in bipolar disorder. Searches for substance use, addiction, triggers, automaticity, and attentional bias found no passage addressing the proposed mechanism for preventing addiction relapse. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 2

  1. [26]26. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition. (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute, 2002.
  2. [37]37. Weissman AN. The dysfunctional attitude scale: a validation study. Dis Abstr Int 1975; 40 :1389 -1390B.

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Related

Authors
Perich, T., Manicavasagar, V., Mitchell, P. B., Ball, J. R., & Hadzi‐Pavlovic, D.
Affiliations
  • Black Dog Institute (AU)
  • UNSW Sydney (AU)
Corresponding author
Perich, T.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2012-12-09
Volume
127
Issue
5
Pages
333-343
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/acps.12033
OpenAlex
W2091992138
Cited by
136
References
44
Citations by year
2026: 6 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 21 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 4 · 2012: 2
FWCI
6.62
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
mindfulness-based cognitive therapy, bipolar disorder, relapse prevention, mood episode recurrence, depressive symptoms, manic symptoms, anxiety symptoms, anxiety comorbidity, usual care
MeSH terms
Adult, Anxiety, Bipolar Disorder, Female, Humans, Male, Patient Compliance, Psychiatric Status Rating Scales, Cognitive Behavioral Therapy, Meditation, Secondary Prevention

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