The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Frailty and Mortality in Kidney Transplant Recipients
Open accessAbstract
We have previously described strong associations between frailty, a measure of physiologic reserve initially described and validated in geriatrics, and early hospital readmission as well as delayed graft function. The goal of this study was to estimate its association with postkidney transplantation (post-KT) mortality. Frailty was prospectively measured in 537 KT recipients at the time of transplantation between November 2008 and August 2013. Cox proportional hazards models were adjusted for confounders using a novel approach to substantially improve model efficiency and generalizability in single-center studies. We precisely estimated the confounder coefficients using the large sample size of the Scientific Registry of Transplantation Recipients (n = 37 858) and introduced these into the single-center model, which then estimated the adjusted frailty coefficient. At 5 years, the survivals were 91.5%, 86.0% and 77.5% for nonfrail, intermediately frail and frail KT recipients, respectively. Frailty was independently associated with a 2.17-fold (95% CI: 1.01-4.65, p = 0.047) higher risk of death. In conclusion, regardless of age, frailty is a strong, independent risk factor for post-KT mortality, even after carefully adjusting for many confounders using a novel, efficient statistical approach.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citationClassification and regression trees
Praagman, J. (1985) · European Journal of Operational Research · doi:10.1016/0377-2217(85)90321-2 · Cited by 10,053
Frailty as a predictor of surgical outcomes in older patients
Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen-Roche, K., Patel, P., Takenaga, R., Devgan, L., Holzmueller, C. G., Tian, J., et al. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.028 · Cited by 2,184
Self-citationPhenotype of frailty: characterization in the women's health and aging studies
Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., & Fried, L. P. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.3.262 · Cited by 1,215
Self-citationWalston, J. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2333 · Cited by 940
Self-citationAssociations of Subclinical Cardiovascular Disease With Frailty
Newman, A. B., Gottdiener, J. S., McBurnie, M. A., Hirsch, C. H., Kop, W. J., Tracy, R., Walston, J. D., & Fried, L. P. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m158 · Cited by 809
Self-citationSarcopenia and Mortality after Liver Transplantation
Englesbe, M. J., Patel, S. P., He, K., Lynch, R. J., Schaubel, D. E., Harbaugh, C., Holcombe, S. A., Wang, S. C., Segev, D. L., & Sonnenday, C. J. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.03.039 · Cited by 766
Self-citationRedefining Geriatric Preoperative Assessment Using Frailty, Disability and Co-Morbidity
Robinson, T. N., Eiseman, B., Wallace, J. I., Church, S. D., McFann, K. K., Pfister, S. M., Sharp, T. J., & Moss, M. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181b45598 · Cited by 543
Simple frailty score predicts postoperative complications across surgical specialties
Robinson, T. N., Wu, D. S., Pointer, L., Dunn, C. L., Cleveland, J. C., & Moss, M. (2013) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2013.03.012 · Cited by 513
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Frailty: implications for clinical practice and public health
Hoogendijk, E. O., Afilalo, J., Ensrud, K. E., Kowal, P., Onder, G., & Fried, L. P. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31786-6 · Cited by 3,282
Development of a novel frailty index to predict mortality in patients with end‐stage liver disease
Lai, J. C., Covinsky, K. E., Dodge, J. L., Boscardin, W. J., Segev, D. L., Roberts, J. P., & Feng, S. (2017) · Hepatology · doi:10.1002/hep.29219 · Cited by 556
“Median (interquartile range; IQR) follow-up time was 11 (4-22) months.”
BackgroundSelf-citationFrailty phenotypes, disability, and outcomes in adult candidates for lung transplantation
Singer, J. P., Diamond, J. M., Gries, C. J., McDonnough, J., Blanc, P. D., Shah, R., Dean, M. Y., Hersh, B., Wolters, P. J., Tokman, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1150oc · Cited by 224
Frailty phenotypes and mortality after lung transplantation: a prospective cohort study
Singer, J. P., Diamond, J. M., Anderson, M. R., Katz, P. P., Covinsky, K., Oyster, M., Blue, T., Soong, A., Kalman, L., Shrestha, P., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14873 · Cited by 133
Frailty trajectories in adult lung transplantation: a cohort study
Venado, A., McCulloch, C., Greenland, J. R., Katz, P., Soong, A., Shrestha, P., Hays, S., Golden, J., Shah, R., Leard, L. E., et al. (2019) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2019.03.006 · Cited by 67
Metadata
- Authors
- McAdams-DeMarco, M. A., Law, A., King, E., Orandi, B., Salter, M., Gupta, N., Chow, E., Alachkar, N., Desai, N., Varadhan, R., Walston, J., & Segev, D. L.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 15
- Issue
- 1
- Pages
- 149-154
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1489963955
- Cited by
- 362
- References
- 24
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McAdams-DeMarco, M. A., Law, A., King, E., Orandi, B., Salter, M., Gupta, N., Chow, E., Alachkar, N., Desai, N., Varadhan, R., Walston, J., & Segev, D. L. (2015). Frailty and Mortality in Kidney Transplant Recipients. American Journal of Transplantation. https://doi.org/10.1111/ajt.12992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
