Cerebrospinal fluid proteome comparison between multiple sclerosis patients and controls
Open accessAbstract
OBJECTIVES: The aim of the present study was to identify proteins in cerebrospinal fluid (CSF) with different abundance between patients with relapsing-remitting multiple sclerosis (RRMS) and controls. Such proteins may be diagnostic biomarkers and contribute with novel information about the disease pathogenesis. MATERIALS AND METHODS: Cerebrospinal fluid from patients with RRMS (n = 17) and controls (n = 17) were trypsin digested and analyzed in a label-free fashion using liquid chromatography mass spectrometry. The resulting data were analyzed using SearchGUI, PeptideShaker, and the Progenesis software. RESULTS: Two hundred and ninety-one proteins were identified, of which 32 were significantly differentially abundant between the patients with RRMS and controls (P-value ≤ 0.05, two or more peptides quantified). Among these were proteins which previously have been linked to MS, including immunoglobulin subunits, vitamin D-binding protein, apolipoprotein D, kallikrein-6, neuronal pentraxin receptor, Dickkopf-related protein 3, and contactin-1. CONCLUSION: The study provides an overview of differentially abundant proteins between RRMS and controls, and a few of these are further discussed. It should be stressed that a larger verification study is needed to reveal the potential value of these proteins as biomarkers for RRMS and their involvement in the disease pathogenesis.
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CSF levels of NPTXR are decreased in multiple sclerosis compared with other neurological disorders.
“One study reported decreased CSF levels of NPTXR in multiple sclerosis compared with other neurological disorders (Kroksveen et al. 2012).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Kroksveen et al. 2012
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- Authors
- Kroksveen, A. C., Guldbrandsen, A., Vedeler, C., Myhr, K. M., Opsahl, J. A., & Berven, F. S.
- Affiliations
- University of Bergen (NO)
- Haukeland University Hospital (NO)
- Corresponding author
- Kroksveen, A. C.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Wiley
- Published
- 2012-12
- Volume
- 126
- Issue
- 195
- Pages
- 90-96
- ISSN
- 0001-6314 (ISSN-L)
- OpenAlex
- W1993759374
- Cited by
- 80
- References
- 40
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 1 · 2012: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen Kristian Gerhard Jebsen
- Norges Forskningsråd
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- relapsing-remitting multiple sclerosis, cerebrospinal fluid proteome, differentially abundant proteins, diagnostic biomarkers, pathogenesis, vitamin D binding protein, apolipoprotein D, kallikrein 6, contactin-1
- MeSH terms
- Adult, Aged, Cerebrospinal Fluid Proteins, Female, Humans, Male, Middle Aged, Vitamin D-Binding Protein, Biomarkers, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Proteome, Proteomics
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