Systematic review with meta-analysis: the impact of a depressive state on disease course in adult inflammatory bowel disease
Open accessAbstract
BACKGROUND: Despite a higher prevalence of psychosocial morbidity in Inflammatory Bowel Disease (IBD), the association between depressive state and disease course in IBD is poorly understood. AIM: To investigate the impact of depressive state on disease course in IBD. METHODS: We conducted a systematic review in MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews and PsychINFO for prospective studies evaluating the impact of baseline depressive state on subsequent disease course in adult IBD. RESULTS: Eleven studies matched our entry criteria, representing 3194 patients with IBD. Three reported on patients with ulcerative colitis (UC), four included patients with Crohn's disease (CD) exclusively, and four studies included both UC and CD. Five studies reported an association between depressive state and disease course. None of the UC-specific studies found any association. In three of four CD-specific studies, a relationship between depressive state and worsening disease course was found. In four of five studies including patients in remission at baseline, no association between depressive state and disease course was found. Pooled analysis of IBD studies with patients in clinical remission at baseline identified no association between depressive state and disease course (HR 1.04, 95%CI: 0.97-1.12). CONCLUSION: There is limited evidence to support an association between depressive state and subsequent deterioration in disease course in IBD, but what data that exist are more supportive of an association with CD than UC. Baseline disease activity may be an important factor in this relationship. Further studies are needed to understand the relationship between mental health and outcomes in IBD.
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A prior systematic review identified only four studies describing brain-to-gut effects that were suitable for meta-analysis.
“A prior systematic review identified only four studies describing brain-to-gut effects that were suitable for meta-analysis.”
From Bidirectional brain-gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis (2022) · cites this paper as [9]
CD patients with depression were more likely to deteriorate than UC patients with depression.
“Another study also showed that CD patients with depression were more likely to deteriorate than UC patients with depression (95).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [95]
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · see citing works
Meta-analysis in clinical trials revisited
DerSimonian, R., & Laird, N. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.09.002 · Cited by 2,677 · see citing works
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
Frolkis, A. D., Dykeman, J., Negrón, M. E., deBruyn, J. C. C., Jetté, N., Fiest, K. M., Frolkis, T. S., Barkema, H. W., Rioux, K. P., Panaccione, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.041 · Cited by 887 · see citing works
Course of ulcerative colitis: Analysis of changes in disease activity over years
Langholz, E., Munkholm, P., Davidsen, M., & Binder, V. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90054-x · Cited by 689 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study
Vernier-Massouille, G., Balde, M., Salleron, J., Turck, D., Dupas, J. L., Mouterde, O., Merle, V., Salomez, J. L., Branche, J., Marti, R., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.079 · Cited by 596 · see citing works
Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532 · see citing works
Stress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Andreoli, A., Luzi, C., Arcà, M., Berto, E., Milite, G., & Marcheggiano, A. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02012.x · Cited by 451 · see citing works
A prospective population-based study of triggers of symptomatic flares in IBD
Bernstein, C. N., Singh, S., Graff, L. A., Walker, J. R., Miller, N., & Cheang, M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.140 · Cited by 400 · see citing works
Mikocka-Walus, A., Pittet, V., Rossel, J.-B., von Känel, R., Anderegg, C., Bauerfeind, P., Beglinger, C., Begré, S., Belli, D., Bengoa, J. M., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.12.045 · Cited by 348 · see citing works
Guthrie, E., Jackson, J., Shaffer, J., Thompson, D., Tomenson, B., & Creed, F. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05842.x · Cited by 306 · see citing works
Gracie, D. J., Irvine, A. J., Sood, R., Mikocka-Walus, A., Hamlin, P. J., & Ford, A. C. (2017) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30206-0 · Cited by 271 · see citing works
Predicting relapse in Crohn’s disease: a biopsychosocial model
Bitton, A., Dobkin, P. L., Edwardes, M. D., Sewitch, M. J., Meddings, J. B., Rawal, S., Cohen, A., Vermeire, S., Dufresne, L., Franchimont, D., et al. (2008) · Gut · doi:10.1136/gut.2007.134817 · Cited by 254 · see citing works
PERSOONS, P., VERMEIRE, S., DEMYTTENAERE, K., FISCHLER, B., VANDENBERGHE, J., VAN OUDENHOVE, L., PIERIK, M., HLAVATY, T., VAN ASSCHE, G., NOMAN, M., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02535.x · Cited by 253 · cited 6× · see citing works
“Only one paper examined depressive state as the unique exposure.(32) All the studies would have been prone to referral centre bias, with the probable exception of Camara et al.”
BackgroundMethodInfluentialThe quality of life in patients with Crohn's disease
Cohen, R. D. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01323.x · Cited by 253 · see citing works
Goodhand, J. R., Wahed, M., Mawdsley, J. E., Farmer, A. D., Aziz, Q., & Rampton, D. S. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22916 · Cited by 234 · see citing works
Psychosocial determinants of relapse in ulcerative colitis: A longitudinal study
Bitton, A., Sewitch, M. J., Peppercorn, M. A., de B Edwardes, M. D., Shah, S., Ransil, B., & Locke, S. E. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07717.x · Cited by 226 · see citing works
Environmental risk factors in inflammatory bowel disease
Leong, R. W. L. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06257.x · Cited by 218 · see citing works
Mardini, H. E., Kip, K. E., & Wilson, J. W. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020509.23162.cc · Cited by 211 · see citing works
Maunder, R., & Levenstein, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533832 · Cited by 198 · see citing works
Sacre, S. M., Medghalchi, M., Gregory, B., Brennan, F. M., & Williams, R. O. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27304 · Cited by 182 · see citing works
Mikocka-Walus, A. A., Turnbull, D. A., Moulding, N. T., Wilson, I. G., Andrews, J. M., & Holtmann, G. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20062 · Cited by 178 · see citing works
Disease and psychological status in ankylosing spondylitis
Martindale, J. H., Smith, J. R., Sutton, C., Grennan, D. M., Goodacre, L., & GOODACRE, J. A. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel115 · Cited by 174 · see citing works
Gracie, D. J., Williams, C. J. M., Sood, R., Mumtaz, S., Bholah, H. M., Hamlin, J. P., & Ford, A. C. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.59 · Cited by 173 · see citing works
Reactivation of inflammatory bowel disease in a mouse model of depression.
Ghia, J., Blennerhassett, P., Deng, Y., Verdú, E., Khan, W., & Collins, S. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.069 · Cited by 171 · see citing works
Inflammation Models of Depression in Rodents: Relevance to Psychotropic Drug Discovery
Remus, J. L., & Dantzer, R. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw028 · Cited by 166 · see citing works
Quality of life of patients with ulcerative colitis: Past, present, and future
Irvine, J. E. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20301 · Cited by 160 · see citing works
Targownik, L. E., Sexton, K. A., Bernstein, M. T., Beatie, B., Sargent, M., Walker, J. R., & Graff, L. A. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2015.147 · Cited by 157 · see citing works
Roy, T., Lloyd, C. E., Pouwer, F., Holt, R. I. G., & Sartorius, N. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03401.x · Cited by 157 · see citing works
Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study
North, C. S., Alpers, D. H., Helzer, J. E., Spitznagel, E. L., & Clouse, R. E. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-381 · Cited by 152 · see citing works
Regueiro, M. D., Kip, K. E., Schraut, W. H., Baidoo, L., Sepulveda, A. R., Pesci, M., El‐Hachem, S., Harrison, J., & Binion, D. G. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21355 · Cited by 146 · see citing works
Mawdsley, J. E., Macey, M. G., Feakins, R. M., Langmead, L., & Rampton, D. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.017 · Cited by 143 · see citing works
Rathbun, A. M., Reed, G. W., & Harrold, L. R. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/kes356 · Cited by 141 · see citing works
Porcell, P., Leoci, C., & Guerra, V. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609010354 · Cited by 139 · see citing works
Goodhand, J., Greig, F. I. S., Koodun, Y., Mcdermott, A., Wahed, M., Langmead, L., & Rampton, D. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21846 · Cited by 131 · see citing works
Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease
Ananthakrishnan, A. N., Gainer, V. S., Perez, R. G., Cai, T., Cheng, S. ‐., Savova, G., Chen, P., Szolovits, P., Xia, Z., De Jager, P. L., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12195 · Cited by 122 · see citing works
Environmental risk factors for inflammatory bowel disease.
Ananthakrishnan, A. N. (2013) · Europe PMC (PubMed Central) · Cited by 119 · see citing works
Yoshida, E. M. (1999) · Canadian Journal of Gastroenterology · doi:10.1155/1999/506915 · Cited by 110 · see citing works
Barahona-Corrêa, B., Xavier, M., & Guimarães, J. (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-1 · Cited by 104 · see citing works
Antidepressants in Inflammatory Bowel Disease: A Systematic Review
Macer, B. J. D., Prady, S. L., & Mikocka-Walus, A. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001059 · Cited by 92 · see citing works
Langhorst, J., Hofstetter, A., Wolfe, F., & Häuser, W. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a192ba · Cited by 85 · see citing works
Sexton, K. A., Walker, J. R., Graff, L. A., Bernstein, M. T., Beatie, B., Miller, N., Sargent, M., & Targownik, L. E. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001040 · Cited by 79 · see citing works
Psychological distress and changes in the activity of systemic lupus erythematosus
Ward, M. M. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.2.184 · Cited by 71 · see citing works
Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review
Häuser, W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i13.3663 · Cited by 70 · see citing works
Faust, A. H., Halpern, L. F., Danoff‐Burg, S., & Cross, R. K. (2012) · Europe PMC (PubMed Central) · Cited by 69 · see citing works
Mood and nonmood components of perceived stress and exacerbation of Crohnʼs disease
Cámara, R. J. A., Schoepfer, A. M., Pittet, V., Begré, S., & von Känel, R. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21623 · Cited by 67 · see citing works
Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn’s Disease
Gaines, L. S., Slaughter, J. C., Horst, S., Schwartz, D. A., Beaulieu, D. B., Haman, K., Wang, L., Martin, C. F., Long, M. D., Sandler, R. S., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.98 · Cited by 60 · see citing works
Mikocka‐Walus, A. A., Hughes, P. A., Bampton, P. A., Gordon, A. L., Campaniello, M. A., Mavrangelos, C., Stewart, B. J. R., Esterman, A., & Andrews, J. M. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw165 · Cited by 57 · see citing works
Mikocka‐Walus, A. A., Turnbull, D. A., Moulding, N., Wilson, I. G., Holtmann, G., & Andrews, J. M. (2008) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-2-11 · Cited by 54 · see citing works
Diagnosis and management of functional symptoms in inflammatory bowel disease in remission
Teruel, C. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i1.78 · Cited by 46 · see citing works
Walter, J. G., Kahn, S. A., Noe, J. D., Schurman, J. V., Miller, S. A., & Greenley, R. N. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000657 · Cited by 43 · see citing works
Shiga, H., Miyazawa, T., Kinouchi, Y., Takahashi, S., Tominaga, G., Takahashi, H., Takagi, S., Obana, N., Kikuchi, T., Oomori, S., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002294 · Cited by 31 · see citing works
Depressive Symptoms in Youth with Inflammatory Bowel Disease Compared with a Community Sample
Reed, B., Lobato, D. J., Hagin, S., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., Bancroft, B., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000442678.62674.b7 · Cited by 30 · see citing works
Long-Term Outcome of Crohn's Disease Following Corticosteroid-Induced Remission
Papi, C., Festa, V., Leandro, G., Moretti, A., Tanga, M., Koch, M., & Capurso, L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01055.x · Cited by 25 · see citing works
Häuser, W., Schmidt, C., & Stallmach, A. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.03.001 · Cited by 20 · see citing works
Schoultz, M., Atherton, I., Hubbard, G., & Watson, A. (2013) · Systematic Reviews · doi:10.1186/2046-4053-2-8 · Cited by 17 · see citing works
Our Vision for the Future of Inflammatory Bowel Diseases
Lashner, B. A., & Cominelli, F. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001018 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- North CS, Alpers DH, Helzer JE, Spitznagel EL, Clouse RE. Do life events or depression exacerbate inflammatory bowel disease. Ann Intern Med. 1991;114:381-386.
- Mikocka-Walus A, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. Antidepressant and inflammatory bowel disease: a systematic review. Clin Pract Epidemiol Ment Heal. 2006;2(15):1-8. doi:10.1186/1745-0179-2-Received. · DOI
Cited by
Sorted by citations
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00014-5 · Cited by 758 · see citing works
Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment
Bisgaard, T. H., Allin, K. H., Keefer, L., Ananthakrishnan, A. N., & Jess, T. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00634-6 · Cited by 572 · see citing works
Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30089-5 · Cited by 358 · see citing works
Fairbrass, K. M., Lovatt, J., Barberio, B., Yuan, Y., Gracie, D. J., & Ford, A. C. (2022) · Gut · doi:10.1136/gutjnl-2021-325985 · Cited by 225 · see citing works
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
The relationship between symptoms of depression and anxiety and disease activity in IBD over time
Marrie, R. A., Graff, L. A., Fisk, J. D., Patten, S. B., & Bernstein, C. N. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa349 · Cited by 128 · see citing works
The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases
Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin‐Biroulet, L., Tsantes, A. G., Brunetta, E., Tsantes, A. Ε., & Bonovas, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030377 · Cited by 114 · see citing works
Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?
Moulton, C. D., Pavlidis, P., Norton, C. S., Norton, S., Pariante, C. M., Hayee, B., & Powell, N. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13276 · Cited by 102 · see citing works
Dubinsky, M. C., Dotan, I., Rubin, D. T., Bernauer, M. J., Patel, D. A., Cheung, R. Y., Modesto, I., Latymer, M., & Keefer, L. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1911644 · Cited by 92 · see citing works
Bisgaard, T. H., Allin, K. H., Elmahdi, R., & Jess, T. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.05.002 · Cited by 72 · see citing works
Thomann, A., Wüstenberg, T., Wirbel, J., Knoedler, L.-L., Thomann, P. A., Zeller, G., Ebert, M., Lis, S., & Reindl, W. (2022) · BMC Medicine · doi:10.1186/s12916-022-02550-7 · Cited by 60 · see citing works
Massironi, S., Pigoni, A., Vegni, E. A. M., Keefer, L., Dubinsky, M. C., Brambilla, P., Delvecchio, G., & Danese, S. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae206 · Cited by 57 · see citing works
Goren, G., Schwartz, D., Friger, M., Banai, H., Sergienko, R., Regev, S., Abu-Kaf, H., Greenberg, D., Nemirovsky, A., Ilan, K., et al. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab083 · Cited by 56 · see citing works
Wintjens, D., de Jong, M. J., Jong, A. E. V. D. M., Romberg-Camps, M. J. L., Becx, M. C., Maljaars, J., Bodegraven, A. A. V., Mahmmod, N., Markus, T., Haans, J. J. L., et al. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy177 · Cited by 48 · see citing works
Stapersma, L., van den Brink, G., van der Ende, J., Szigethy, E. M., Beukers, R., Korpershoek, T. A., Theuns-Valks, S. D. M., Hillegers, M. H. J., Escher, J. C., & Utens, E. M. W. J. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy029 · Cited by 46 · see citing works
Psychiatric comorbidities in patients with inflammatory bowel disease
Bhamre, R., Sawrav, S., Adarkar, S. A., Sakaria, R. P., & Bhatia, S. J. (2018) · Indian Journal of Gastroenterology · doi:10.1007/s12664-018-0870-9 · Cited by 41 · see citing works
Viganò, C. A., Beltrami, M., Bosi, M. F., Zanello, R., Valtorta, M., & Maconi, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00324 · Cited by 42 · see citing works
Arp, L., Jansson, S., Wewer, V., & Burisch, J. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjac095 · Cited by 38 · see citing works
Schoultz, M., Beattie, M., Gorely, T., & Leung, J. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01426-2 · Cited by 36 · see citing works
Hinnant, L., Rios Villacorta, N., Chen, E., Bacchus, D., Dotson, J., Greywoode, R., Keefer, L., Lupe, S., Maggs, L., Meek, G., et al. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae151 · Cited by 31 · see citing works
High Frequency of Undiagnosed Psychiatric Disorders in Inflammatory Bowel Diseases
Marafini, I., Longo, L., Lavasani, D. M., Rossi, R., Salvatori, S., Pianigiani, F., Calabrese, E., Siracusano, A., Lorenzo, G. D., & Monteleone, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051387 · Cited by 31 · see citing works
Ning, L., Wang, X., Xuan, B., Ma, Y., Yan, Y., Gao, Z., Tong, T., Cui, Z., Chen, H., Li, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1145070 · Cited by 30 · see citing works
Asscher, V. E. R., Kong, V. Y., Kort, E. D., van Deudekom, F. J., Mooijaart, S. P., & Maljaars, J. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz082 · Cited by 29 · see citing works
From inflammation to depression: key biomarkers for IBD-related major depressive disorder
Hu, C., Ge, M., Liu, Y., Tan, W., Zhang, Y., Zou, M., Xiang, L., Song, X., & Guo, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05758-8 · Cited by 26 · see citing works
Wang, J., Liu, G., Xu, K., Ai, K., Huang, W., & Zhang, J. (2023) · Human Brain Mapping · doi:10.1002/hbm.26439 · Cited by 27 · see citing works
van den Brink, G., Stapersma, L., Bom, A. S., Rizopolous, D., van der Woude, C. J., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., Beukers, R., Korpershoek, T. A., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz073 · Cited by 23 · see citing works
Alexakis, C., Saxena, S. K., Chhaya, V., Cecil, E. V., Majeed, A., & Pollok, R. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0273-7 · Cited by 22 · see citing works
Clinical decision support improves quality of care in patients with ulcerative colitis
Jackson, B. D., Begun, J., Gray, K. M., Churilov, L. P., Liew, D., Knowles, S. R., & Cruz, P. P. D. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15209 · Cited by 19 · see citing works
The incidence rate of herpes zoster in inflammatory bowel disease
Lai, S., Liao, K., Lin, C., Kuo, Y., Liu, C.-S., & Hwang, B. (2021) · Medicine · doi:10.1097/md.0000000000026863 · Cited by 19 · see citing works
Yu, R., Liu, C., Zhang, J., Li, J., Tian, S., Ding, F., Liu, Z., Wang, T., Liu, Z., Jiang, C., et al. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s407388 · Cited by 20 · see citing works
Kim, S., Lee, S., Han, K., Koh, S., Im, J. P., Kim, J. S., & Lee, H. J. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.01.015 · Cited by 17 · see citing works
Wu, Q., Zhu, P., Liu, X., Chen, C., Ji, Q., & Gu, Q. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1007318 · Cited by 16 · see citing works
Hill, E., Nguyen, N. H., Qian, A. S., Patel, S., Chen, P. L., Tse, C.-S., & Singh, S. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07505-9 · Cited by 15 · see citing works
Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease
Ji, Y., Li, H., Dai, G., Zhang, X., & Ju, W. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16568 · Cited by 15 · see citing works
Nguyen, N. H., Zhang, X., Long, M. D., Sandborn, W. J., Kappelman, M. D., & Singh, S. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07082-3 · Cited by 14 · see citing works
Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
Teng, S., Yang, Y., Zhang, W., Li, X.-J., Li, W., Cui, Z.-L., Min, L., & Wu, J. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01538-5 · Cited by 12 · see citing works
Blackwell, J., Alexakis, C., Saxena, S. K., Creese, H., Bottle, A., Petersen, I., Hotopf, M. H., & Pollok, R. (2021) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2020-000588 · Cited by 14 · see citing works
Keefer, L. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14212 · Cited by 12 · see citing works
Sneineh, A. T. A., Ali, S. H., Al-Masri, A., Diab, A., Aldweik, F., Darweesh, M., Qaisi, M. I. A., Alshakhatreh, O., Tamimi, T., Rayyan, Y. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11911-4 · Cited by 11 · see citing works
Does Reverse Causality Underlie the Temporal Relationship Between Depression and Crohn’s Disease?
Gaines, L. S., Slaughter, J. C., Schwartz, D. A., Beaulieu, D. B., Horst, S., Dalal, R. L., Scoville, E., Sandler, R. S., & Kappelman, M. D. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz123 · Cited by 11 · see citing works
The relationship of major depressive disorder with Crohn's disease activity
Facanali, C. B. G., Sobrado Junior, C. W., Fraguas Junior, R., Facanali Junior, M. R., Boarini, L. R., Sobrado, L. F., & Cecconello, I. (2023) · Clinics · doi:10.1016/j.clinsp.2023.100188 · Cited by 10 · see citing works
AL-Aamri, H., Al‐Huseini, S., Chan, M. F., Saadi, A. A., Al‐Sibani, N., Al-Dughaishi, Z., & Al‐Alawi, M. (2021) · Oman Medical Journal · doi:10.5001/omj.2022.48 · Cited by 10 · see citing works
Psychological interventions for treatment of inflammatory bowel disease
Tiles-Sar, N., Neuser, J., de Sordi, D., Baltes, A., Preiß, J., Moser, G., & Timmer, A. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006913.pub3 · Cited by 12 · see citing works
Oh, S. J., Choi, C. H., Jung, S.-A., Song, G. A., Kim, Y. J., Koo, J. S., Shin, S. J., Seo, G. S., Lee, K., Jang, B. I., et al. (2024) · Gut and Liver · doi:10.5009/gnl240146 · Cited by 9 · see citing works
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3746277 · Cited by 9 · see citing works
Cebolla, A., Navarrete, J., González-Moret, R., Cortés, X., Soria, J. M., Baños, R. M., & Lisón, J. F. (2021) · Mindfulness · doi:10.1007/s12671-021-01741-2 · Cited by 8 · see citing works
Neurological Manifestations and Psychiatric Disorders in the Course of Inflammatory Bowel Diseases
Głuch, P., Swiatek, A., Dudek, P., Fabisiak, A., & Talar‐Wojnarowska, R. (2022) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-3965 · Cited by 8 · see citing works
Wang, L., Liang, C., Chen, P., Cao, Y., & Zhang, Y. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231155022 · Cited by 7 · see citing works
Nardone, O. M., Bruzzese, D., Allocca, M., Calabrese, G., Caprioli, F., Danese, S., Fantini, M. C., Onali, S., Orlando, A., Rispo, A., et al. (2024) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.11.004 · Cited by 6 · see citing works
Liao, C., Tan, Y., Wang, K., Wen, X., Hu, X., Huang, Y., & Li, Y. (2023) · Pain Research and Management · doi:10.1155/2023/3315090 · Cited by 6 · see citing works
Scaldaferri, F., D’Onofrio, A. M., Chiera, E., Gomez-Nguyen, A., Ferrajoli, G. F., Vincenzo, F. D., Petito, V., Laterza, L., Pugliese, D., Napolitano, D., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13061208 · Cited by 6 · see citing works
Epidemiologie der chronisch-entzündlichen Darmerkrankungen
Timmer, A. (2020) · Springer eBooks · doi:10.1007/978-3-662-59104-8_2 · Cited by 3 · see citing works
Devereaux, J., Robinson, A. M., Stavely, R. G., Davidson, M., Filippone, R. T., Ephraim, R., Kiatos, D., Apostolopoulos, V., & Nurgali, K. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03536-x · Cited by 2 · see citing works
Health Maintenance in Patients with Ulcerative Colitis
Harper, J. W. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.08.004 · Cited by 2 · see citing works
Sánta, A., Szántó, K. J., Miheller, P., Sarlós, P., Juhász, A., Hallgató, E., Farkas, K., Rafael, B., & Molnár, T. F. (2020) · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) · Cited by 2 · see citing works
Densil, A., George, M. E., Mahdi, H., Chami, A., Mark, A., Luo, C., Wang, Y., Ali, A., Tang, P., Dong, A., et al. (2023) · Frontiers in Systems Biology · doi:10.3389/fsysb.2023.1274184 · Cited by 1 · see citing works
Sánta, A., Szántó, K. J., Miheller, P., Sarlós, P., Juhász, A., Hamvas, E., Szegedi-Hallgató, E., Farkas, K., Rafael, B., & Molnár, T. (2020) · Orvosi Hetilap · doi:10.1556/650.2020.31875 · Cited by 1 · see citing works
Alexakis, C., Kumar, S., Saxena, S. K., Hotopf, M. H., & Pollok, R. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14223 · Cited by 1 · see citing works
Gastrointestinale Erkrankungen
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_6
Inflammatory bowel disease and cognitive behavioral therapy (CBT) in the young
Stapersma, L., Escher, J. C., & Utens, E. M. W. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85757-4.00015-8
CO-OCCURRENCE OF INFLAMMATORY BOWEL DISEASE AND PSYCHIATRIC DISEASES
Bisgaard, T. H. (2023) · doi:10.54337/aau614553280
Teng, S., Yang, Y., Zhang, W., Li, X., Li, W., Cui, Z., Min, L., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26692444
Teng, S., Yang, Y., Zhang, W., Li, X., Li, W., Cui, Z., Min, L., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26692447
Thomann, A., Wüstenberg, T., Wirbel, J., Knoedler, L.-L., Thomann, P. A., Zeller, G., Ebert, M., Lis, S., & Reindl, W. (2022) · Figshare · doi:10.6084/m9.figshare.21343282
Estudo da relação entre o estresse psicológico e a exacerbação de doenças inflamatórias intestinais
Santos, H. E., Nogueira, A. C. C., Teles, A. L. R., de Resende, A. N. C. M., de Giuli, G., Vial, G. L. C., Cota, K. R. M., Santos, L. F. M., de Souza, L. S., Silva, T. A. D. A., et al. (2026) · Caderno Pedagógico · doi:10.54033/cadpedv23n1-151
Depression and the Immune Responses
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_10
Ibrahim, E. A., Saleh, N., Mansour, M., Alnounou, A., Mohamed, I., Ghnaimat, A. A., Mahmoud, M. R., Kaelber, D. C., & Almomani, A. (2026) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2026.2732411
OLFM4, LCN2 and FAM3B as Potential Biomarkers for Gut–Brain Axis Dysfunction in IBD-MDD Comorbidity
Li, F., Zhao, J., Song, B., Wang, J., & Zhang, J. (2026) · Genes · doi:10.3390/genes17101245
- Authors
- Alexakis, C., Kumar, S., Saxena, S., & Pollok, R.
- Affiliations
- St George’s University Hospitals NHS Foundation Trust (GB)
- Imperial College London (GB)
- Corresponding author
- Pollok, R.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2017-06-02
- Volume
- 46
- Issue
- 3
- Pages
- 225-235
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2620927568
- Cited by
- 69
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- National Institute for Health Research (CDF‐2011‐04‐048)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, depressive state, depression, clinical course, Crohn's disease, ulcerative colitis, clinical remission, disease activity, mental health, psychosocial morbidity
- MeSH terms
- Adult, Colitis, Ulcerative, Crohn Disease, Depression, Humans, Prevalence, Databases, Factual, Disease Progression
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