Cited by 138Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

Pharmacotherapy for smoking cessation: pharmacological principles and clinical practice

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Aubin, Henri‐Jean, Luquiens, Amandine, Berlin, Ivan·2014·British Journal of Clinical Pharmacology

Abstract

Strategies for assisting smoking cessation include behavioural counselling to enhance motivation and to support attempts to quit and pharmacological intervention to reduce nicotine reinforcement and withdrawal from nicotine. Three drugs are currently used as first line pharmacotherapy for smoking cessation, nicotine replacement therapy, bupropion and varenicline. Compared with placebo, the drug effect varies from 2.27 (95% CI 2.02, 2.55) for varenicline, 1.69 (95% CI 1.53, 1.85) for bupropion and 1.60 (95% CI 1.53, 1.68) for any form of nicotine replacement therapy. Despite some controversy regarding the safety of bupropion and varenicline, regulatory agencies consider these drugs as having a favourable benefit/risk profile. However, given the high rate of psychiatric comorbidity in dependent smokers, practitioners should closely monitor patients for neuropsychiatric symptoms. Second‐line pharmacotherapies include nortriptyline and clonidine. This review also offers an overview of pipeline developments and issues related to smoking cessation in special populations such as persons with psychiatric comorbidity and pregnant and adolescent smokers.

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  1. Jimenez-Ruiz C, Berlin I, Hering T. Varenicline: a novel pharmacotherapy for smoking cessation. Drugs 2009; 69: 1319-38.

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Authors
Aubin, H., Luquiens, A., & Berlin, I.
Affiliations
  • Inserm (FR)
  • Pitié-Salpêtrière Hospital (FR)
Corresponding author
Aubin, Henri‐Jean
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2014-01-22
Volume
77
Issue
2
Pages
324-336
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
OpenAlex
W1778717419
Cited by
138
References
167
Citations by year
2026: 8 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 8 · 2020: 12 · 2019: 4 · 2018: 11 · 2017: 17 · 2016: 13 · 2015: 8 · 2014: 6 · 2013: 4
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
smoking cessation, nicotine replacement therapy, bupropion, varenicline, nicotine dependence, nicotine withdrawal, nicotine reinforcement, nortriptyline, clonidine, psychiatric comorbidity, neuropsychiatric adverse effects, pregnant smokers, adolescent smokers, drug safety
MeSH terms
Varenicline, Adolescent, Benzazepines, Counseling, Female, Humans, Molecular Sequence Data, Pregnancy, Quinoxalines, Tobacco Use Disorder, Drug Design, Smoking Cessation, Bupropion, Tobacco Use Cessation Devices

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